AU2004224322A1 - Methods of treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators - Google Patents
Methods of treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators Download PDFInfo
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- AU2004224322A1 AU2004224322A1 AU2004224322A AU2004224322A AU2004224322A1 AU 2004224322 A1 AU2004224322 A1 AU 2004224322A1 AU 2004224322 A AU2004224322 A AU 2004224322A AU 2004224322 A AU2004224322 A AU 2004224322A AU 2004224322 A1 AU2004224322 A1 AU 2004224322A1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Electrotherapy Devices (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45683503P | 2003-03-21 | 2003-03-21 | |
| US60/456,835 | 2003-03-21 | ||
| US48614803P | 2003-07-10 | 2003-07-10 | |
| US60/486,148 | 2003-07-10 | ||
| US50957003P | 2003-10-08 | 2003-10-08 | |
| US60/509,570 | 2003-10-08 | ||
| US53487104P | 2004-01-08 | 2004-01-08 | |
| US60/534,871 | 2004-01-08 | ||
| US54825004P | 2004-02-27 | 2004-02-27 | |
| US60/548,250 | 2004-02-27 | ||
| PCT/US2004/008605 WO2004084879A1 (en) | 2003-03-21 | 2004-03-22 | Methods for treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004224322A2 AU2004224322A2 (en) | 2004-10-07 |
| AU2004224322A1 true AU2004224322A1 (en) | 2004-10-07 |
Family
ID=33102559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004224322A Abandoned AU2004224322A1 (en) | 2003-03-21 | 2004-03-22 | Methods of treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US20040198822A1 (pl) |
| EP (2) | EP1492519B1 (pl) |
| JP (1) | JP2006520799A (pl) |
| KR (1) | KR100742001B1 (pl) |
| CN (1) | CN1791399A (pl) |
| AT (1) | ATE345120T1 (pl) |
| AU (1) | AU2004224322A1 (pl) |
| BR (1) | BRPI0408608A (pl) |
| CA (1) | CA2519694A1 (pl) |
| DE (1) | DE602004003172T2 (pl) |
| DK (1) | DK1492519T3 (pl) |
| ES (1) | ES2275229T3 (pl) |
| PL (2) | PL378583A1 (pl) |
| WO (1) | WO2004084879A1 (pl) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843303B1 (fr) * | 2002-08-07 | 2006-01-21 | R & D Pharma | Nouvelles compositions pharmaceutiques destinees au traitement de l'incontinence urinaire |
| US20040180958A1 (en) * | 2002-12-13 | 2004-09-16 | Taylor Charles Price | Method of treatment |
| JP2006511606A (ja) | 2002-12-13 | 2006-04-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 下部尿路症状を治療するα−２−δリガンド |
| EP1621193A3 (en) * | 2002-12-20 | 2006-08-02 | Dynogen Pharmaceuticals Inc. | Treatment of non-painful bladder disorders using alpha2-delta-subunit calcium channel modulators |
| AU2003301184A1 (en) * | 2002-12-20 | 2004-07-22 | Dynogen Pharmaceuticals Inc | METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING Alpha2Delta SUBUNIT CALCIUM CHANNEL MODULATORS |
| DE602004003172T2 (de) * | 2003-03-21 | 2007-09-27 | Dynogen Pharmaceuticals Inc., Waltham | Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| CA2537837A1 (en) | 2003-09-11 | 2005-03-24 | Xenoport, Inc. | Treating and/or preventing urinary incontinence using prodrugs of gaba analogs |
| US20050175689A1 (en) * | 2003-10-27 | 2005-08-11 | Yamanouchi Pharmaceutical Co., Ltd. | Coated fine particles containing drug for intrabuccally fast disintegrating tablet |
| EP1728791A4 (en) * | 2004-03-25 | 2008-12-10 | Astellas Pharma Inc | COMPOSITIONS FOR SOLID PHARMACEUTICAL PREPARATION OF SOLIFENACIN OR BZW. A SALT OF IT |
| TWI356699B (en) * | 2004-11-10 | 2012-01-21 | Kissei Pharmaceutical | Agent for treating interstitial cystitis and agent |
| US20070135377A1 (en) * | 2004-12-10 | 2007-06-14 | Roman Stephen B | Thixotropic anti-viral formulation |
| EP1832288B1 (en) * | 2004-12-27 | 2012-06-20 | Astellas Pharma Inc. | Stable granular pharmaceutical composition of solifenacin or its salt |
| EP1844773A4 (en) * | 2005-02-03 | 2010-04-28 | Kyorin Seiyaku Kk | PREPARATION FOR PERCUTANEOUS ABSORPTION |
| WO2006101954A2 (en) * | 2005-03-17 | 2006-09-28 | Indevus Pharmaceuticals, Inc. | Interstitial cystitis treatment |
| EP1906951A4 (en) * | 2005-07-01 | 2009-05-27 | Dynogen Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR TREATING HYPOMOTILITY OF THE DIGESTIVE SYSTEM AND RELATED DISORDERS |
| EP1741444A1 (en) * | 2005-07-05 | 2007-01-10 | Jerini AG | Kinin antagonists for treating bladder dysfunction |
| US7815939B2 (en) * | 2005-07-20 | 2010-10-19 | Astellas Pharma Inc. | Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms |
| US20070190139A1 (en) * | 2006-02-13 | 2007-08-16 | Intelgenx Corp. | Delayed release pharmaceutical oral dosage form and method of making same |
| US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
| US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
| CN104069567A (zh) | 2007-03-19 | 2014-10-01 | 茵苏莱恩医药有限公司 | 药物输送设备 |
| DE102007019071A1 (de) * | 2007-04-23 | 2008-10-30 | Ratiopharm Gmbh | Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin |
| US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| AU2008259864C1 (en) * | 2007-05-30 | 2014-03-06 | Microdose Therapeutx, Inc. | Methods and compositions for administration of Oxybutynin |
| US8415390B2 (en) | 2008-05-30 | 2013-04-09 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
| US20110171195A1 (en) * | 2007-06-15 | 2011-07-14 | Duke University | Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp |
| US8409133B2 (en) | 2007-12-18 | 2013-04-02 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
| WO2009151613A1 (en) * | 2008-06-13 | 2009-12-17 | Concert Pharmaceuticals, Inc. | Oxybutynin derivatives |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| CN102245137A (zh) | 2008-11-07 | 2011-11-16 | 茵苏莱恩医药有限公司 | 用于药物递送的装置和方法 |
| US9180263B2 (en) * | 2009-07-01 | 2015-11-10 | Microdose Therapeutx, Inc. | Laboratory animal pulmonary dosing device |
| US20110000481A1 (en) * | 2009-07-01 | 2011-01-06 | Anand Gumaste | Nebulizer for infants and respiratory compromised patients |
| CA2784041C (en) | 2010-01-05 | 2017-11-07 | Microdose Therapeutx, Inc. | Inhalation device and method |
| US8377956B2 (en) | 2010-03-01 | 2013-02-19 | Xenoport, Inc. | Use of (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl) butanoic acid for treating urinary incontinence |
| US9119878B2 (en) | 2010-07-08 | 2015-09-01 | Wellesley Pharmaceuticals, Llc | Extended-release formulation for reducing the frequency of urination and method of use thereof |
| KR20180023057A (ko) * | 2012-01-04 | 2018-03-06 | 웰즐리 파마슈티컬스 엘엘씨 | 배뇨 빈도를 감소시키기 위한 서방형 제제 및 이의 사용 방법 |
| EP2612663A1 (en) * | 2012-01-04 | 2013-07-10 | Wellesley Pharmaceuticals, LLC | Extended-release formulation for reducing the frequency of urination and method of use thereof |
| JP2015503583A (ja) * | 2012-01-04 | 2015-02-02 | ウェルズリー ファーマスーティカルズ、エルエルシー | 排尿頻度を減少させるための延長放出製剤およびその使用の方法 |
| EP2612662B1 (en) * | 2012-01-04 | 2020-03-04 | Wellesley Pharmaceuticals, LLC | Delayed-release formulation for reducing the frequency of urination and method of use thereof |
| MX2014011128A (es) * | 2012-03-19 | 2015-08-10 | Wellesley Pharmaceuticals Llc | Formulacion de liberacion prolongada para reducir la frecuencia de miccion y metodo de uso de la misma. |
| WO2014047287A1 (en) * | 2012-09-24 | 2014-03-27 | Cormatrix Cardiovascular, Inc. | Multi-needle injection apparatus and system for delivering pharmacological agents to biological tissue |
| US10596127B2 (en) | 2013-03-14 | 2020-03-24 | Wellesley Pharmaceuticals, Llc | Composition for reducing the frequency of urination, method of making and use thereof |
| EP2929878A1 (en) * | 2014-04-09 | 2015-10-14 | Arven Ilac Sanayi ve Ticaret A.S. | Extended release formulations of gabapentin |
| US10022446B2 (en) | 2014-08-22 | 2018-07-17 | Koç Üniversitesi | PH responsive hybrid hydrogel and method of synthesis thereof |
| WO2016028237A1 (en) * | 2014-08-22 | 2016-02-25 | Koç Üniversitesi | A novel ph responsive hydrogel and method of synthesis |
| JP6957460B2 (ja) | 2015-10-22 | 2021-11-02 | カビオン・インコーポレイテッドＣａｖｉｏｎ， Ｉｎｃ． | アンジェルマン症候群および関連する障害の処置方法 |
| KR20190017795A (ko) * | 2016-05-13 | 2019-02-20 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 아드레날린 수용체 조절 화합물 및 이의 사용 방법 |
| WO2018071443A1 (en) | 2016-10-11 | 2018-04-19 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
| MX2019012818A (es) | 2017-04-26 | 2020-07-14 | Cavion Inc | Metodos para mejorar la memoria y la cognicion y para el tratamiento de trastornos de la memoria y cognitivos. |
| JP7320494B2 (ja) * | 2017-05-26 | 2023-08-03 | ノバッセイ エスエー | 電圧ゲート式カルシウムチャネル補助サブユニットα２δおよびその使用 |
| TW202027728A (zh) | 2018-10-03 | 2020-08-01 | 美商卡凡恩公司 | 以(r)-2-(4-異丙基苯基)-n-(1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙基)乙醯胺治療自發性震顫 |
| KR20200056719A (ko) * | 2018-11-15 | 2020-05-25 | 단국대학교 천안캠퍼스 산학협력단 | 가바펜티노이드를 포함하는, 척수손상 개체의 신경재생 또는 신경회복을 위한 조성물 |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
| US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
| US2005A (en) * | 1841-03-16 | Improvement in the manner of constructing molds for casting butt-hinges | ||
| US5180715A (en) * | 1980-11-17 | 1993-01-19 | The Regents Of The University Of California | Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate |
| US5116615A (en) * | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
| DE3928183A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
| WO1995009167A1 (fr) * | 1993-09-30 | 1995-04-06 | Tokyo Tanabe Company Limited | Derive d'indoline et antagoniste du recepteur 5-ht3 contenant ce derive et utilise comme ingredient actif |
| US5698549A (en) * | 1994-05-12 | 1997-12-16 | Uva Patent Foundation | Method of treating hyperactive voiding with calcium channel blockers |
| NO2005012I1 (no) * | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| US5912268A (en) * | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
| US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
| US5674895A (en) * | 1995-05-22 | 1997-10-07 | Alza Corporation | Dosage form comprising oxybutynin |
| US5610136A (en) * | 1996-01-30 | 1997-03-11 | Milkhaus Laboratory, Inc. | Method for treatment of benign prostatic hypertrophy |
| US5738873A (en) * | 1996-09-27 | 1998-04-14 | Herman Bleiweiss | Pharmaceutical formulations and methods for treating patients suffering from diseases that cause muscular hypotonia |
| US6255526B1 (en) * | 1996-12-24 | 2001-07-03 | Teva Pharmaceutical Industries Ltd. | Preparation of gabapentin |
| US6150396A (en) * | 1997-03-07 | 2000-11-21 | Eli Lilly And Company | Methods of treating or preventing interstitial cystitis |
| WO1998046216A1 (fr) * | 1997-04-11 | 1998-10-22 | Nippon Shinyaku Co., Ltd. | Traitements des mictions frequentes et de l'incontinence urinaire |
| US6329429B1 (en) * | 1997-06-25 | 2001-12-11 | Warner-Lambert Company | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases |
| EP0919234A3 (en) * | 1997-10-17 | 1999-08-25 | Eli Lilly And Company | Potentiation of pharmaceuticals by moxonidine |
| FR2771093B1 (fr) * | 1997-11-19 | 2000-01-21 | Synthelabo | Derives d'imidazole, leur preparation et leur application en therapeutique |
| US6319920B1 (en) * | 1998-02-27 | 2001-11-20 | Syntex (U.S.A.) Llc | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives |
| US6482837B1 (en) * | 1998-04-24 | 2002-11-19 | University Of Rochester | Antimuscarinic compounds and methods for treatment of bladder diseases |
| CA2322558C (en) * | 1998-05-26 | 2006-04-11 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
| IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
| JP2002541198A (ja) * | 1999-04-08 | 2002-12-03 | ワーナー−ランバート・カンパニー | 失禁の治療法 |
| BR0012058A (pt) * | 1999-07-02 | 2002-05-14 | Warner Lambert Co | Combinação sinérgica: gabapentina e pregabalina |
| AP2002002501A0 (en) * | 1999-10-07 | 2002-06-30 | Warner Lambert Co | Synergistic combinations of an NK1 receptor antagonist and a gaba structural analog. |
| FR2801217B1 (fr) * | 1999-11-24 | 2002-12-06 | Aventis Pharma Sa | Association de riluzole et de gabapentine et son utilisation comme medicament |
| WO2001054728A1 (en) * | 2000-01-28 | 2001-08-02 | Asahi Kasei Kabushiki Kaisha | NOVEL REMEDIES WITH THE USE OF β3 AGONIST |
| AU2001266992B8 (en) * | 2000-06-16 | 2005-12-01 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin having pH within a controlled range |
| WO2001097612A1 (en) * | 2000-06-16 | 2001-12-27 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin containing more than 2o ppm of chlorine ion |
| US7056951B2 (en) * | 2000-09-26 | 2006-06-06 | Mutual Pharmaceutical Co., Inc. | Stable solid dosage forms of amino acids and processes for producing same |
| PL365378A1 (pl) * | 2000-11-30 | 2005-01-10 | Pfizer Products Inc. | Kompozycje agonistów GABA i inhibitorów reduktazyaldozowej |
| GB0119435D0 (en) * | 2001-02-15 | 2001-10-03 | Aventis Pharm Prod Inc | Method of treating of demyelinating diseases or conditions |
| WO2002069906A2 (en) * | 2001-03-06 | 2002-09-12 | Cellegy Pharmaceuticals, Inc. | Compounds and methods for the treatment of urogenital disorders |
| ITMI20011308A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
| MXPA04008175A (es) * | 2002-02-22 | 2004-11-26 | Warner Lambert Co | Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la ciclooxigenasa-2. |
| US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| JP2006511606A (ja) | 2002-12-13 | 2006-04-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 下部尿路症状を治療するα−２−δリガンド |
| AU2003301184A1 (en) * | 2002-12-20 | 2004-07-22 | Dynogen Pharmaceuticals Inc | METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING Alpha2Delta SUBUNIT CALCIUM CHANNEL MODULATORS |
| DE602004003172T2 (de) * | 2003-03-21 | 2007-09-27 | Dynogen Pharmaceuticals Inc., Waltham | Verfahren zur behandlung von erkrankungen der unteren harnwege mit antimuskarinika und mit modulatoren der alpha-2-delta untereinheit des kalziumkanals |
| DE602004007225T2 (de) * | 2003-04-04 | 2008-03-06 | Dynogen Pharmaceuticals Inc., Waltham | Methode zur behandlung von erkrankungen der unteren harnwege |
-
2004
- 2004-03-22 DE DE602004003172T patent/DE602004003172T2/de not_active Expired - Fee Related
- 2004-03-22 ES ES04757949T patent/ES2275229T3/es not_active Expired - Lifetime
- 2004-03-22 PL PL378583A patent/PL378583A1/pl not_active Application Discontinuation
- 2004-03-22 CN CNA2004800137225A patent/CN1791399A/zh active Pending
- 2004-03-22 AT AT04757949T patent/ATE345120T1/de not_active IP Right Cessation
- 2004-03-22 EP EP04757949A patent/EP1492519B1/en not_active Expired - Lifetime
- 2004-03-22 KR KR1020057017665A patent/KR100742001B1/ko not_active IP Right Cessation
- 2004-03-22 WO PCT/US2004/008605 patent/WO2004084879A1/en active IP Right Grant
- 2004-03-22 JP JP2006507421A patent/JP2006520799A/ja active Pending
- 2004-03-22 AU AU2004224322A patent/AU2004224322A1/en not_active Abandoned
- 2004-03-22 DK DK04757949T patent/DK1492519T3/da active
- 2004-03-22 US US10/805,977 patent/US20040198822A1/en not_active Abandoned
- 2004-03-22 EP EP06010942A patent/EP1721607A1/en not_active Withdrawn
- 2004-03-22 BR BRPI0408608-2A patent/BRPI0408608A/pt not_active IP Right Cessation
- 2004-03-22 CA CA002519694A patent/CA2519694A1/en not_active Abandoned
- 2004-03-22 PL PL04757949T patent/PL1492519T3/pl unknown
-
2005
- 2005-05-10 US US11/126,062 patent/US20050239890A1/en not_active Abandoned
-
2006
- 2006-04-07 US US11/400,666 patent/US20060247311A1/en not_active Abandoned
- 2006-11-13 US US11/598,393 patent/US20070060652A1/en not_active Abandoned
-
2007
- 2007-12-07 US US11/952,422 patent/US20080085916A1/en not_active Abandoned
-
2008
- 2008-04-11 US US12/082,419 patent/US20080275080A1/en not_active Abandoned
-
2011
- 2011-08-09 US US13/206,216 patent/US20110294881A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080085916A1 (en) | 2008-04-10 |
| CA2519694A1 (en) | 2004-10-07 |
| DK1492519T3 (da) | 2007-03-05 |
| US20040198822A1 (en) | 2004-10-07 |
| BRPI0408608A (pt) | 2006-03-07 |
| ATE345120T1 (de) | 2006-12-15 |
| US20050239890A1 (en) | 2005-10-27 |
| AU2004224322A2 (en) | 2004-10-07 |
| DE602004003172D1 (de) | 2006-12-28 |
| DE602004003172T2 (de) | 2007-09-27 |
| KR20050111784A (ko) | 2005-11-28 |
| PL378583A1 (pl) | 2006-05-02 |
| ES2275229T3 (es) | 2007-06-01 |
| JP2006520799A (ja) | 2006-09-14 |
| EP1721607A1 (en) | 2006-11-15 |
| KR100742001B1 (ko) | 2007-07-23 |
| US20110294881A1 (en) | 2011-12-01 |
| CN1791399A (zh) | 2006-06-21 |
| US20060247311A1 (en) | 2006-11-02 |
| US20080275080A1 (en) | 2008-11-06 |
| EP1492519A1 (en) | 2005-01-05 |
| US20070060652A1 (en) | 2007-03-15 |
| WO2004084879A1 (en) | 2004-10-07 |
| EP1492519B1 (en) | 2006-11-15 |
| PL1492519T3 (pl) | 2007-04-30 |
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