AU2003303714B2 - Improved linkers for radiopharmaceutical compounds - Google Patents
Improved linkers for radiopharmaceutical compounds Download PDFInfo
- Publication number
- AU2003303714B2 AU2003303714B2 AU2003303714A AU2003303714A AU2003303714B2 AU 2003303714 B2 AU2003303714 B2 AU 2003303714B2 AU 2003303714 A AU2003303714 A AU 2003303714A AU 2003303714 A AU2003303714 A AU 2003303714A AU 2003303714 B2 AU2003303714 B2 AU 2003303714B2
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- Prior art keywords
- acid
- amino
- compound
- substituted bile
- bile acid
- Prior art date
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- 239000012217 radiopharmaceutical Substances 0.000 title claims description 22
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- 239000012216 imaging agent Substances 0.000 claims abstract description 17
- 230000003439 radiotherapeutic effect Effects 0.000 claims abstract description 16
- 238000002059 diagnostic imaging Methods 0.000 claims abstract description 12
- 125000005647 linker group Chemical group 0.000 claims description 124
- 239000003613 bile acid Substances 0.000 claims description 123
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 120
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Optics & Photonics (AREA)
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- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43972203P | 2003-01-13 | 2003-01-13 | |
| US60/439,722 | 2003-01-13 | ||
| PCT/US2003/041656 WO2004062574A2 (en) | 2003-01-13 | 2003-12-24 | Improved linkers for radiopharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003303714A1 AU2003303714A1 (en) | 2004-08-10 |
| AU2003303714B2 true AU2003303714B2 (en) | 2009-02-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003303714A Ceased AU2003303714B2 (en) | 2003-01-13 | 2003-12-24 | Improved linkers for radiopharmaceutical compounds |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7989417B2 (https=) |
| EP (1) | EP1583564B1 (https=) |
| JP (1) | JP4610345B2 (https=) |
| CN (1) | CN100534535C (https=) |
| AT (1) | ATE435035T1 (https=) |
| AU (1) | AU2003303714B2 (https=) |
| CA (1) | CA2512310C (https=) |
| DE (1) | DE60328226D1 (https=) |
| WO (1) | WO2004062574A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US8420050B2 (en) * | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| CA2512310C (en) * | 2003-01-13 | 2012-09-25 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7611692B2 (en) * | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| CA2549318A1 (en) * | 2003-12-24 | 2005-07-28 | Enrico Cappelletti | Improved gastrin releasing peptide compounds |
| AU2005265048B2 (en) * | 2004-06-18 | 2011-06-16 | Elamleh, David R. | Intravascular imaging device and uses thereof |
| KR20090014164A (ko) * | 2006-04-19 | 2009-02-06 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 세포 영상화 및 치료를 위한 조성물 및 방법 |
| US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| EP2604284A1 (en) * | 2007-02-16 | 2013-06-19 | KTB Tumorforschungsgesellschaft mbH | Receptor And Antigen Targeted Prodrug |
| WO2008144728A1 (en) * | 2007-05-21 | 2008-11-27 | Bracco Imaging S.P.A. | Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications |
| EP2895204B1 (en) | 2012-09-13 | 2020-10-21 | Provincial Health Services Authority | Compositions targeting bradykinin receptor b1 for medical imaging of cancer and other disorders |
| CN104744568B (zh) * | 2013-12-25 | 2018-02-23 | 华东理工大学 | 对神经激肽‑1受体蛋白特异性识别的p物质多肽探针及其制备与应用 |
| GB201417067D0 (en) | 2014-09-26 | 2014-11-12 | South African Nuclear Energy | Radiopharmaceutical conjugate |
| US20190029637A1 (en) * | 2016-01-29 | 2019-01-31 | The Regents Of The University Of California | A wearable sensor, and method, to monitor anti-coagulation therapy |
| CN109970834A (zh) * | 2019-02-27 | 2019-07-05 | 郑州明泽医药科技有限公司 | 一种氢化可的松琥珀酸钠的制备方法 |
| CN112067556B (zh) * | 2020-09-29 | 2021-08-17 | 湖北鑫英泰系统技术股份有限公司 | 一种油浸式设备油气检测方法及装置 |
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|---|---|---|---|---|
| US5646272A (en) * | 1989-09-14 | 1997-07-08 | Hoechst Aktiengesellschaft | Bile acid conjugates of proline hydroxylase inhibitors |
| US6153729A (en) * | 1997-06-20 | 2000-11-28 | St. Jude's Children's Research Hospital | Isolated nuclear matrix targeting peptide |
| WO2001009163A2 (en) * | 1999-07-30 | 2001-02-08 | The University Court Of The University Of Glasgow | Improvement of peptide transport by conjugation with bile acids |
| WO2001064708A1 (en) * | 2000-02-29 | 2001-09-07 | Bracco Imaging S.P.A. | Bile acids conjugates with metal ion chelates and the use thereof |
| US6461588B1 (en) * | 1998-12-23 | 2002-10-08 | Bracco Imaging S.P.A. | Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics |
| WO2002087597A1 (en) * | 2001-04-30 | 2002-11-07 | Mediplex Corporation | Oral delivery of macromolecules |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5534497A (en) * | 1986-05-28 | 1996-07-09 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| AU618029B2 (en) * | 1987-11-02 | 1991-12-12 | Imperial Chemical Industries Plc | Polypeptide compounds |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| ES2070329T3 (es) | 1989-07-20 | 1995-06-01 | Sandoz Ltd | Derivados de polipeptidos. |
| US5217955A (en) * | 1989-09-15 | 1993-06-08 | Biomeasure, Inc. | Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin |
| US5811387A (en) * | 1990-05-15 | 1998-09-22 | Chiron Corporation | Peptoid mixtures |
| US5834433A (en) * | 1990-07-26 | 1998-11-10 | Merrell Pharmaceuticals Inc. | Compounds and pharmaceutical uses of peptides of bombesin and GRP |
| US5620959A (en) * | 1990-07-31 | 1997-04-15 | Glaxo Wellcome Inc. | Bombesin antagonists |
| US5369094A (en) * | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
| US5244883A (en) * | 1990-11-29 | 1993-09-14 | The Administrators Of The Tulane Educational Fund | Nonapeptide bombesin antagonists |
| AU659659B2 (en) * | 1991-05-23 | 1995-05-25 | Merrell Dow Pharmaceuticals Inc. | Bombesin analogs |
| EP0626973A1 (en) * | 1992-02-07 | 1994-12-07 | Merrell Pharmaceuticals Inc. | Phenylalanine analogs of bombesin |
| US5620955A (en) * | 1993-06-18 | 1997-04-15 | Peptide Technologies Corporation | Bombesin receptor antagonists and uses thereof |
| US5410018A (en) * | 1994-02-25 | 1995-04-25 | Oregon Regional Primate Research Center | Bombesin-related peptides |
| US5662885A (en) | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| EP0975374B1 (en) * | 1996-07-12 | 2007-12-05 | Immunomedics, Inc. | Radiometal-binding peptide analogues |
| CA2283854A1 (en) * | 1997-04-22 | 1998-10-29 | The Curators Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
| DE69939036D1 (de) * | 1998-04-28 | 2008-08-14 | Serono Lab | PEG Konjugate von LHRH Analogen |
| US6866837B2 (en) * | 1998-06-05 | 2005-03-15 | Mallinckrodt Inc. | Radiolabeled peptides for the diagnosis and treatment of breast and prostate tumors and metastases of such tumors |
| CA2405151A1 (en) | 2000-04-07 | 2001-10-18 | University Of Maryland, Baltimore | Bile acid containing prodrugs with enhanced bioavailability |
| CA2512310C (en) * | 2003-01-13 | 2012-09-25 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
-
2003
- 2003-12-24 CA CA2512310A patent/CA2512310C/en not_active Expired - Fee Related
- 2003-12-24 EP EP03808615A patent/EP1583564B1/en not_active Expired - Lifetime
- 2003-12-24 AT AT03808615T patent/ATE435035T1/de not_active IP Right Cessation
- 2003-12-24 DE DE60328226T patent/DE60328226D1/de not_active Expired - Lifetime
- 2003-12-24 JP JP2004566646A patent/JP4610345B2/ja not_active Expired - Fee Related
- 2003-12-24 AU AU2003303714A patent/AU2003303714B2/en not_active Ceased
- 2003-12-24 US US10/542,396 patent/US7989417B2/en not_active Expired - Fee Related
- 2003-12-24 CN CNB2003801087500A patent/CN100534535C/zh not_active Expired - Fee Related
- 2003-12-24 WO PCT/US2003/041656 patent/WO2004062574A2/en not_active Ceased
-
2011
- 2011-07-08 US US13/179,035 patent/US20110280802A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646272A (en) * | 1989-09-14 | 1997-07-08 | Hoechst Aktiengesellschaft | Bile acid conjugates of proline hydroxylase inhibitors |
| US6153729A (en) * | 1997-06-20 | 2000-11-28 | St. Jude's Children's Research Hospital | Isolated nuclear matrix targeting peptide |
| US6461588B1 (en) * | 1998-12-23 | 2002-10-08 | Bracco Imaging S.P.A. | Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics |
| WO2001009163A2 (en) * | 1999-07-30 | 2001-02-08 | The University Court Of The University Of Glasgow | Improvement of peptide transport by conjugation with bile acids |
| WO2001064708A1 (en) * | 2000-02-29 | 2001-09-07 | Bracco Imaging S.P.A. | Bile acids conjugates with metal ion chelates and the use thereof |
| WO2002087597A1 (en) * | 2001-04-30 | 2002-11-07 | Mediplex Corporation | Oral delivery of macromolecules |
Non-Patent Citations (1)
| Title |
|---|
| Bioconjugate Chemistry, 1991, 2(2), pp 117-23 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2512310A1 (en) | 2004-07-29 |
| EP1583564B1 (en) | 2009-07-01 |
| US7989417B2 (en) | 2011-08-02 |
| ATE435035T1 (de) | 2009-07-15 |
| AU2003303714A1 (en) | 2004-08-10 |
| DE60328226D1 (de) | 2009-08-13 |
| CN1738652A (zh) | 2006-02-22 |
| WO2004062574A9 (en) | 2005-05-26 |
| JP2006513247A (ja) | 2006-04-20 |
| CA2512310C (en) | 2012-09-25 |
| WO2004062574A2 (en) | 2004-07-29 |
| US20110280802A1 (en) | 2011-11-17 |
| EP1583564A4 (en) | 2007-06-13 |
| US20060241018A1 (en) | 2006-10-26 |
| EP1583564A2 (en) | 2005-10-12 |
| CN100534535C (zh) | 2009-09-02 |
| JP4610345B2 (ja) | 2011-01-12 |
| WO2004062574A3 (en) | 2005-04-14 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |