AU2003256308B2 - Minimally compliant, volume efficient piston for osmotic drug delivery systems - Google Patents

Minimally compliant, volume efficient piston for osmotic drug delivery systems Download PDF

Info

Publication number
AU2003256308B2
AU2003256308B2 AU2003256308A AU2003256308A AU2003256308B2 AU 2003256308 B2 AU2003256308 B2 AU 2003256308B2 AU 2003256308 A AU2003256308 A AU 2003256308A AU 2003256308 A AU2003256308 A AU 2003256308A AU 2003256308 B2 AU2003256308 B2 AU 2003256308B2
Authority
AU
Australia
Prior art keywords
piston
osmotic
capsule
agent
interior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003256308A
Other languages
English (en)
Other versions
AU2003256308A1 (en
Inventor
Scott D. Lautenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Intarcia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intarcia Therapeutics Inc filed Critical Intarcia Therapeutics Inc
Publication of AU2003256308A1 publication Critical patent/AU2003256308A1/en
Assigned to INTARCIA THERAPEUTICS, INC. reassignment INTARCIA THERAPEUTICS, INC. Request for Assignment Assignors: ALZA CORPORATION
Application granted granted Critical
Publication of AU2003256308B2 publication Critical patent/AU2003256308B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003256308A 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems Ceased AU2003256308B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39200402P 2002-06-26 2002-06-26
US60/392,004 2002-06-26
PCT/US2003/020130 WO2004002565A1 (en) 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems

Publications (2)

Publication Number Publication Date
AU2003256308A1 AU2003256308A1 (en) 2004-01-19
AU2003256308B2 true AU2003256308B2 (en) 2008-07-03

Family

ID=30000792

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003256308A Ceased AU2003256308B2 (en) 2002-06-26 2003-06-25 Minimally compliant, volume efficient piston for osmotic drug delivery systems

Country Status (19)

Country Link
US (3) US6939556B2 (cg-RX-API-DMAC7.html)
EP (1) EP1551493B1 (cg-RX-API-DMAC7.html)
JP (1) JP4485945B2 (cg-RX-API-DMAC7.html)
KR (1) KR101046903B1 (cg-RX-API-DMAC7.html)
CN (1) CN100453130C (cg-RX-API-DMAC7.html)
AT (1) ATE376854T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003256308B2 (cg-RX-API-DMAC7.html)
BR (1) BR0312429A (cg-RX-API-DMAC7.html)
CA (1) CA2490544C (cg-RX-API-DMAC7.html)
DE (1) DE60317225T2 (cg-RX-API-DMAC7.html)
EC (1) ECSP055578A (cg-RX-API-DMAC7.html)
ES (1) ES2295642T3 (cg-RX-API-DMAC7.html)
IL (1) IL165975A (cg-RX-API-DMAC7.html)
MX (1) MXPA05000224A (cg-RX-API-DMAC7.html)
NO (1) NO20050368L (cg-RX-API-DMAC7.html)
NZ (1) NZ537628A (cg-RX-API-DMAC7.html)
TW (1) TW200531709A (cg-RX-API-DMAC7.html)
WO (1) WO2004002565A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200500744B (cg-RX-API-DMAC7.html)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
EP1578398A2 (en) * 2002-12-19 2005-09-28 ALZA Corporation Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
KR20060017749A (ko) * 2003-03-31 2006-02-27 알자 코포레이션 내압 소멸 수단을 갖는 삼투성 펌프
BRPI0408921A (pt) * 2003-03-31 2006-03-28 Alza Corp sistema de distribuição osmótico e método para diminuir os tempos de inìcio para os sistemas de distribuição osmóticos
CA2545027A1 (en) * 2003-11-06 2005-05-26 Alza Corporation Modular imbibition rate reducer for use with implantable osmotic pump
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
MX2007006120A (es) 2004-11-23 2007-12-07 Adamas Pharmaceuticals Inc Metodo y composicion para administrar a un sujeto un antagonista del receptor de nmda.
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
EP1845968A2 (en) 2004-11-24 2007-10-24 Neuromolecular Pharmaceuticals, Inc Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
WO2006084141A2 (en) * 2005-02-03 2006-08-10 Intarcia Therapeutics, Inc Suspension formulation of interferon
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
RU2007140348A (ru) 2005-04-06 2009-05-20 Адамас Фармасьютикалс, Инк. (Us) Способы и композиции для лечения заболеваний цнс
EP1948183B1 (en) * 2005-10-13 2013-12-18 Duke University Compositions for the treatment and prevention of heart disease and methods of using same
ES2351527T3 (es) 2006-05-30 2011-02-07 Intarcia Therapeutics, Inc Modulador de flujo en dos piezas con conducto interno para un sistema osmótico de administración.
KR101200728B1 (ko) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 삼투성 전달 시스템 및 피스톤 조립체
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US8105261B2 (en) * 2007-07-02 2012-01-31 Cardiac Pacemakers, Inc. Osmotic devices and methods for diuretic therapy
US8394644B2 (en) 2007-11-08 2013-03-12 Honeywell International Inc. Microfluidic osmotic pump
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
WO2010044867A1 (en) * 2008-10-15 2010-04-22 Intarcia Therapeutics, Inc. Highly concentrated drug particles, formulations, suspensions and uses thereof
WO2010151896A1 (en) * 2009-06-26 2010-12-29 Taris Biomedical, Inc. Solid drug tablets for implantable drug delivery devices
HRP20171801T1 (hr) 2009-09-28 2017-12-29 Intarcia Therapeutics, Inc. Brzo uspostavljanje i/ili brzo završavanje uglavnom stabilne primjene lijeka
RU2012117898A (ru) 2009-09-30 2013-11-10 Те Риджентс Оф Те Юниверсити Оф Калифорния Кофакторы и способы их применения индивидуумами
MX2012006320A (es) 2009-12-02 2013-01-18 Adamas Pharmaceuticals Inc Composiciones de amantadina y metodos para su uso.
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN108261547A (zh) 2011-07-15 2018-07-10 纽斯尔特科学公司 用于调节代谢途径的组合物和方法
US9198454B2 (en) 2012-03-08 2015-12-01 Nusirt Sciences, Inc. Compositions, methods, and kits for regulating energy metabolism
KR101723319B1 (ko) * 2012-10-12 2017-04-04 일라이 릴리 앤드 캄파니 화학 엔진, 및 특히 고점성 유체의 주사에서의 그의 사용을 위한 방법
JP6469015B2 (ja) 2012-11-13 2019-02-13 ニューサート サイエンシーズ， インコーポレイテッド エネルギー代謝を増大させるための組成物および方法
EP2945616B1 (en) 2013-01-15 2018-11-28 NuSirt Sciences, Inc. Treating pulmonary conditions
WO2014138214A1 (en) * 2013-03-05 2014-09-12 Taris Biomedical, Inc. Drug delivery devices and methods for controlled drug release through device orifice
JP6550370B2 (ja) 2013-03-15 2019-07-24 ニューサート サイエンシーズ， インコーポレイテッド 脂質レベルを低下させるロイシンおよびニコチン酸
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
AU2015222754B2 (en) 2014-02-27 2020-06-25 Nusirt Sciences Inc. Compositions and methods for the reduction or prevention of hepatic steatosis
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CN113598842A (zh) 2015-06-03 2021-11-05 因塔西亚制药公司 植入物放置和移除系统
EP3370705B1 (en) 2015-11-05 2022-03-09 The General Hospital Corporation Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy
US10973783B2 (en) 2015-12-30 2021-04-13 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of seizure-related disorders
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
KR20190086460A (ko) 2016-10-20 2019-07-22 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 신경보호 폴리펩티드를 중추 신경계에 전달하는 방법
WO2018129058A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
JP6841937B2 (ja) 2017-02-17 2021-03-10 イーライ リリー アンド カンパニー 化学反応による流体の送達のためのプロセスおよびデバイス
KR20190126335A (ko) 2017-03-08 2019-11-11 인타르시아 세라퓨틱스 인코포레이티드 약물 전달 장치로부터 메스꺼움 유발 화합물을 투여하기 위한 장치 및 방법
WO2018200885A1 (en) 2017-04-26 2018-11-01 Neurocentria, Inc. Magnesium compositions and methods of use
JP6971385B2 (ja) 2017-09-08 2021-11-24 イーライ リリー アンド カンパニー 薬剤送達デバイス内のガス発生を制御するためのシステム
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
US12128201B2 (en) 2018-08-23 2024-10-29 Baywind Bioventures Capsule device for delivery of active agent to gastrointestinal tract
SG11202103586UA (en) 2018-10-11 2021-05-28 Intarcia Therapeutics Inc Human amylin analog polypeptides and methods of use
CA3123210A1 (en) 2018-12-19 2020-06-25 Eli Lilly And Company Devices and processes for delivery of therapeutic fluids
US12133972B2 (en) 2018-12-19 2024-11-05 Eli Lilly And Company Systems, devices, and processes for delivery of therapeutic fluids
WO2025160155A1 (en) 2024-01-22 2025-07-31 The Broad Institute, Inc. Epigenetic targeting of prion diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030216A (en) * 1989-12-15 1991-07-09 Alza Corporation Osmotically driven syringe
US5985305A (en) * 1996-02-02 1999-11-16 Alza Corporation Sustained delivery of an active agent using an implantable system
US6287295B1 (en) * 1997-07-25 2001-09-11 Alza Corporation Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753651A (en) 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
US4765989A (en) * 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4558888A (en) * 1983-09-19 1985-12-17 Minnesota Mining And Manufacturing Company Strip of binding tape
US4874388A (en) 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5728088A (en) * 1988-12-13 1998-03-17 Alza Corporation Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
US5234424A (en) * 1988-12-28 1993-08-10 Alza Corporation Osmotically driven syringe
US4969884A (en) * 1988-12-28 1990-11-13 Alza Corporation Osmotically driven syringe
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5324280A (en) * 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5180591A (en) 1990-07-11 1993-01-19 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5861166A (en) * 1991-03-12 1999-01-19 Alza Corporation Delivery device providing beneficial agent stability
CN2085662U (zh) * 1991-03-29 1991-10-02 毕勇 药物″渗透泵″的生产装置
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
DE69229881T2 (de) 1991-10-04 1999-12-09 Yoshitomi Pharmaceutical Industries, Ltd. Tablette mit verzögerter freisetzung
NZ244682A (en) * 1991-10-10 1993-12-23 Alza Corp Osmotically driven controlled delivery device characterised in that a
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5456679A (en) * 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5209746A (en) 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
US5221278A (en) * 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
US5458888A (en) * 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
US6395292B2 (en) * 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
DE69822208T2 (de) 1997-12-29 2005-04-28 Alza Corp., Mountain View Osmotisches verabreichungssystem mit stöpselrückhaltemechanismus
NZ512410A (en) * 1998-12-17 2003-02-28 Alza Corp Controlled release liquid filled gelatin capsules comprising barrier, expandable and superpermeable layers and an orifice
WO2002036072A2 (en) * 2000-11-03 2002-05-10 Biomedicines, Inc. Method for short-term and long-term drug dosimetry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030216A (en) * 1989-12-15 1991-07-09 Alza Corporation Osmotically driven syringe
US5985305A (en) * 1996-02-02 1999-11-16 Alza Corporation Sustained delivery of an active agent using an implantable system
US6287295B1 (en) * 1997-07-25 2001-09-11 Alza Corporation Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems

Also Published As

Publication number Publication date
BR0312429A (pt) 2005-04-19
EP1551493A1 (en) 2005-07-13
EP1551493B1 (en) 2007-10-31
JP4485945B2 (ja) 2010-06-23
ECSP055578A (es) 2005-04-18
US6939556B2 (en) 2005-09-06
CA2490544C (en) 2011-04-19
CN100453130C (zh) 2009-01-21
CN1671439A (zh) 2005-09-21
ES2295642T3 (es) 2008-04-16
AU2003256308A1 (en) 2004-01-19
DE60317225T2 (de) 2008-05-29
US7112335B2 (en) 2006-09-26
ZA200500744B (en) 2006-03-29
NZ537628A (en) 2005-12-23
ATE376854T1 (de) 2007-11-15
KR20050026416A (ko) 2005-03-15
KR101046903B1 (ko) 2011-07-06
US20070088337A1 (en) 2007-04-19
WO2004002565A1 (en) 2004-01-08
NO20050368L (no) 2005-01-24
TW200531709A (en) 2005-10-01
CA2490544A1 (en) 2004-01-08
IL165975A (en) 2009-07-20
US20060111693A1 (en) 2006-05-25
MXPA05000224A (es) 2005-06-03
JP2005530588A (ja) 2005-10-13
IL165975A0 (en) 2006-01-15
HK1080402A1 (en) 2006-04-28
DE60317225D1 (de) 2007-12-13
US20040019345A1 (en) 2004-01-29

Similar Documents

Publication Publication Date Title
AU2003256308B2 (en) Minimally compliant, volume efficient piston for osmotic drug delivery systems
AU771132B2 (en) Osmotic delivery system having space efficient piston
US6899887B2 (en) Osmotic delivery system with membrane plug retention mechanism
EP1736145B1 (en) Beneficial agent delivery system with membrane plug
HK1080402B (en) Minimally compliant, volume efficient piston for osmotic drug delivery systems

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: INTARCIA THERAPEUTICS, INC.

Free format text: FORMER APPLICANT(S): ALZA CORPORATION

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired