AU2003230852B2 - TNP-470 polymer conjugates and use thereof - Google Patents
TNP-470 polymer conjugates and use thereof Download PDFInfo
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- AU2003230852B2 AU2003230852B2 AU2003230852A AU2003230852A AU2003230852B2 AU 2003230852 B2 AU2003230852 B2 AU 2003230852B2 AU 2003230852 A AU2003230852 A AU 2003230852A AU 2003230852 A AU2003230852 A AU 2003230852A AU 2003230852 B2 AU2003230852 B2 AU 2003230852B2
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
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|---|---|---|---|
| AU2008229857A AU2008229857A1 (en) | 2002-04-11 | 2008-10-09 | TNP-470 polymer conjugates and use thereof |
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| US37179102P | 2002-04-11 | 2002-04-11 | |
| US60/371,791 | 2002-04-11 | ||
| US41470502P | 2002-09-30 | 2002-09-30 | |
| US60/414,705 | 2002-09-30 | ||
| PCT/US2003/010976 WO2003086382A1 (en) | 2002-04-11 | 2003-04-10 | Tnp-470 polymer conjugates and use thereof |
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| AU2008229857A Division AU2008229857A1 (en) | 2002-04-11 | 2008-10-09 | TNP-470 polymer conjugates and use thereof |
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| AU2003230852A1 AU2003230852A1 (en) | 2003-10-27 |
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| JP (1) | JP4514455B2 (enExample) |
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| CA (1) | CA2480666C (enExample) |
| ES (1) | ES2398381T3 (enExample) |
| WO (1) | WO2003086382A1 (enExample) |
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| US20030100605A1 (en) * | 2001-05-15 | 2003-05-29 | Grupp Stephan A. | Methods of treating cancer with angiogenesis inhibitors |
| WO2003086178A2 (en) * | 2002-04-11 | 2003-10-23 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
| ES2398381T3 (es) * | 2002-04-11 | 2013-03-15 | Children's Medical Center Corporation | Conjugados del copolímero de ácido metacrílico-hpma-tnp-470 y sus usos |
| US20080248030A1 (en) * | 2005-02-02 | 2008-10-09 | Children's Medical Center Corporation | Method of Treating Angiogenic Diseases |
| EP1919882A2 (en) | 2005-02-17 | 2008-05-14 | Synta Pharmaceuticals Corporation | Isoxazole combretastatin derivatives for the treatment of proliferative disorders |
| EP2170402B1 (en) | 2007-06-26 | 2015-03-25 | Children's Medical Center Corporation | Metap-2 inhibitor polymersomes for therapeutic administration |
| WO2009036108A1 (en) * | 2007-09-13 | 2009-03-19 | Children's Medical Center Corporation | Methods and compositions for inhibiting vascular leakage |
| WO2009049089A1 (en) | 2007-10-09 | 2009-04-16 | Washington University In St. Louis | Ligand directed toroidal nanoparticles for therapy and diagnostic imaging |
| US9446150B2 (en) | 2007-10-09 | 2016-09-20 | Washington University | Particles for imaging |
| EA020251B1 (ru) * | 2007-11-28 | 2014-09-30 | Мерсана Терапьютикс, Инк. | Биосовместимые и биоразлагаемые конъюгаты аналогов фумагиллина |
| EP2307032A4 (en) * | 2008-05-22 | 2014-08-20 | Univ Ramot | NEW CONJUGATES OF POLYMERS WITH A THERAPEUTIC AGENT AND AN ANGIOGENESIS TARGETING PART CONTAINED THEREOF, AND USES IN THE TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS |
| US8658149B2 (en) | 2008-05-22 | 2014-02-25 | Ramot At Tel-Aviv University Ltd. | Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases |
| US8703114B2 (en) | 2008-05-22 | 2014-04-22 | Ramot At Tel-Aviv University Ltd. | Conjugate of a polymer, an anti-angiogenesis agent and a targeting moiety, and uses thereof in the treatment of bone related angiogenesis conditions |
| US8715685B2 (en) * | 2009-07-14 | 2014-05-06 | Lucia Irene Gonzalez | Stereoisomer peptides and their polymer conjugates for HIV disease |
| US8715986B2 (en) * | 2009-10-29 | 2014-05-06 | Lucia Irene Gonzalez | Stereoisomer peptides, ligand-targeted multi- stereoisomer peptide polymer conjugates, and uses thereof |
| WO2011084700A1 (en) | 2009-12-17 | 2011-07-14 | The Washington University | Antithrombotic nanoparticle |
| US9808500B2 (en) | 2009-12-17 | 2017-11-07 | Washington University | Antithrombotic nanoparticle |
| AU2011239414A1 (en) | 2010-04-15 | 2012-11-08 | The Washington University | Prodrug compositions, prodrug nanoparticles, and methods of use thereof |
| US20110294952A1 (en) * | 2010-05-25 | 2011-12-01 | SynDevRX | Optimized Drug Conjugates |
| US9895449B2 (en) * | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| US9320805B2 (en) * | 2010-05-25 | 2016-04-26 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| EP2822598A4 (en) | 2012-03-05 | 2016-04-13 | Univ Ramot | POLYMERS HAVING THERAPEUTICALLY ACTIVE AGENTS CONJUGATED THERETO, METHODS FOR THE PREPARATION OF SAID POLYMERS AND USES THEREOF |
| BR112015025892A2 (pt) | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
| EP3020114B1 (en) | 2013-07-11 | 2017-05-17 | General Electric Company | Grid power factor control system |
| TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
| KR102849342B1 (ko) | 2015-12-10 | 2025-08-21 | 신데브알엑스, 인크. | 푸마길롤 유도체 및 그의 다형체 |
| KR20180100663A (ko) | 2016-01-11 | 2018-09-11 | 신데브알엑스, 인크. | 대사 기능장애에 의하여 유도된 종양에 대한 치료 |
| KR20200096939A (ko) * | 2017-12-06 | 2020-08-14 | 제넨테크, 인크. | 면역조직화학을 위한 합성 대조군 |
| JP2022512826A (ja) | 2018-10-26 | 2022-02-07 | シンデブルックス，インコーポレイティド | ＭｅｔＡＰ２阻害剤のバイオマーカーとその応用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097776A1 (fr) * | 2000-06-22 | 2001-12-27 | Takeda Chemical Industries, Ltd. | Composition médicamenteuse contenant un polymère |
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| GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
| US5164410A (en) | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| EP0359036B1 (en) | 1988-09-01 | 1997-03-26 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives |
| US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5180738A (en) | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US6017954A (en) | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| EP0889041B1 (en) | 1996-03-06 | 2002-07-24 | TSUMURA & CO. | Novel iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| US6225478B1 (en) | 1997-03-05 | 2001-05-01 | Tsumura & Co. | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| WO2001036002A1 (en) * | 1999-11-17 | 2001-05-25 | School Of Pharmacy, University Of London | Conjugates of hpma copolymer and ellipticin |
| ATE552859T1 (de) * | 2000-09-13 | 2012-04-15 | Praecis Pharm Inc | Pharmazeutische formulierungen zur kontinuierlichen abgabe von peptiden |
| US6548477B1 (en) * | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US6919307B2 (en) * | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US7084108B2 (en) * | 2000-11-01 | 2006-08-01 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| WO2003086178A2 (en) | 2002-04-11 | 2003-10-23 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
| ES2398381T3 (es) * | 2002-04-11 | 2013-03-15 | Children's Medical Center Corporation | Conjugados del copolímero de ácido metacrílico-hpma-tnp-470 y sus usos |
| CA2550873A1 (en) * | 2003-12-29 | 2005-07-21 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
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- 2003-04-10 ES ES03723958T patent/ES2398381T3/es not_active Expired - Lifetime
- 2003-04-10 AU AU2003230852A patent/AU2003230852B2/en not_active Ceased
- 2003-04-10 WO PCT/US2003/010976 patent/WO2003086382A1/en not_active Ceased
- 2003-04-10 CA CA2480666A patent/CA2480666C/en not_active Expired - Lifetime
- 2003-04-10 EP EP03723958A patent/EP1494662B1/en not_active Expired - Lifetime
- 2003-04-10 US US10/511,009 patent/US7332523B2/en not_active Expired - Lifetime
- 2003-04-10 JP JP2003583402A patent/JP4514455B2/ja not_active Expired - Fee Related
-
2004
- 2004-02-19 US US10/783,986 patent/US6949584B2/en not_active Expired - Lifetime
-
2005
- 2005-07-20 US US11/185,538 patent/US20060020024A1/en not_active Abandoned
-
2007
- 2007-12-18 US US11/958,688 patent/US20080112919A1/en not_active Abandoned
-
2008
- 2008-10-09 AU AU2008229857A patent/AU2008229857A1/en not_active Abandoned
- 2008-12-02 US US12/326,134 patent/US20090176874A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001097776A1 (fr) * | 2000-06-22 | 2001-12-27 | Takeda Chemical Industries, Ltd. | Composition médicamenteuse contenant un polymère |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529870A (ja) | 2005-10-06 |
| US7332523B2 (en) | 2008-02-19 |
| CA2480666A1 (en) | 2003-10-23 |
| US20080112919A1 (en) | 2008-05-15 |
| US20060020024A1 (en) | 2006-01-26 |
| US20040229945A1 (en) | 2004-11-18 |
| CA2480666C (en) | 2012-03-06 |
| WO2003086382A1 (en) | 2003-10-23 |
| EP1494662A4 (en) | 2006-07-19 |
| ES2398381T3 (es) | 2013-03-15 |
| US20090176874A1 (en) | 2009-07-09 |
| AU2003230852A1 (en) | 2003-10-27 |
| EP1494662B1 (en) | 2012-11-28 |
| EP1494662A1 (en) | 2005-01-12 |
| AU2008229857A1 (en) | 2008-10-30 |
| JP4514455B2 (ja) | 2010-07-28 |
| US20050169881A1 (en) | 2005-08-04 |
| US6949584B2 (en) | 2005-09-27 |
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