AU2003215826A1 - Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase - Google Patents
Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymeraseInfo
- Publication number
- AU2003215826A1 AU2003215826A1 AU2003215826A AU2003215826A AU2003215826A1 AU 2003215826 A1 AU2003215826 A1 AU 2003215826A1 AU 2003215826 A AU2003215826 A AU 2003215826A AU 2003215826 A AU2003215826 A AU 2003215826A AU 2003215826 A1 AU2003215826 A1 AU 2003215826A1
- Authority
- AU
- Australia
- Prior art keywords
- hepatitis
- inhibitors
- pyrandion
- pyranon
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 241000711549 Hepacivirus C Species 0.000 title abstract 4
- 108060004795 Methyltransferase Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical compound O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 title 1
- CZVTYGFISHLVHK-UHFFFAOYSA-N 4h-pyran-2,3-dione Chemical compound O=C1CC=COC1=O CZVTYGFISHLVHK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36938102P | 2002-04-01 | 2002-04-01 | |
| US60/369,381 | 2002-04-01 | ||
| PCT/IB2003/001206 WO2003082848A1 (en) | 2002-04-01 | 2003-03-21 | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003215826A1 true AU2003215826A1 (en) | 2003-10-13 |
Family
ID=28675577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003215826A Abandoned AU2003215826A1 (en) | 2002-04-01 | 2003-03-21 | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6878727B2 (enExample) |
| EP (1) | EP1490350B1 (enExample) |
| JP (1) | JP2005526102A (enExample) |
| AT (1) | ATE337309T1 (enExample) |
| AU (1) | AU2003215826A1 (enExample) |
| BR (1) | BR0308856A (enExample) |
| CA (1) | CA2480583C (enExample) |
| DE (1) | DE60307804T2 (enExample) |
| ES (1) | ES2268394T3 (enExample) |
| MX (1) | MXPA04009672A (enExample) |
| WO (1) | WO2003082848A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DOP2003000641A (es) * | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) * | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| IN2012DN04853A (enExample) | 2004-02-20 | 2015-09-25 | Boehringer Ingelheim Int | |
| US7115749B2 (en) | 2004-10-29 | 2006-10-03 | Schering Corporation | Substituted 5-oxo pyrazoles and [1,2,4]triazoles as antiviral agents |
| EP1881828A4 (en) * | 2005-05-20 | 2009-06-03 | Valeant Res & Dev | TREATMENT OF HEPATITIS C (HCV) USING SUB-THERAPEUTIC DOSES OF RIBAVIRIN |
| US7816348B2 (en) * | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2008047694A1 (fr) * | 2006-10-13 | 2008-04-24 | Aska Pharmaceutical Co., Ltd. | Procédé de fabrication d'un composé benzothiazole |
| EP2494991A1 (en) | 2007-05-04 | 2012-09-05 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
| CA2693495A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| EP2188274A4 (en) * | 2007-08-03 | 2011-05-25 | Boehringer Ingelheim Int | VIRAL POLYMERASE HEMMER |
| EA201000948A1 (ru) | 2007-12-19 | 2011-02-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы вирусной полимеразы |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140049A (en) * | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| US5846964A (en) * | 1993-07-19 | 1998-12-08 | Tokyo Tanabe Company Limited | Hepatitis C virus proliferation inhibitor |
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| AU777040B2 (en) * | 1999-02-22 | 2004-09-30 | Shire Biochem Inc. | (1,8) naphthyridine derivatives having antiviral activity |
| AR034127A1 (es) * | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
-
2003
- 2003-03-21 AU AU2003215826A patent/AU2003215826A1/en not_active Abandoned
- 2003-03-21 EP EP03745205A patent/EP1490350B1/en not_active Expired - Lifetime
- 2003-03-21 BR BR0308856-1A patent/BR0308856A/pt not_active IP Right Cessation
- 2003-03-21 DE DE60307804T patent/DE60307804T2/de not_active Expired - Fee Related
- 2003-03-21 WO PCT/IB2003/001206 patent/WO2003082848A1/en not_active Ceased
- 2003-03-21 CA CA002480583A patent/CA2480583C/en not_active Expired - Fee Related
- 2003-03-21 AT AT03745205T patent/ATE337309T1/de not_active IP Right Cessation
- 2003-03-21 JP JP2003580314A patent/JP2005526102A/ja not_active Abandoned
- 2003-03-21 MX MXPA04009672A patent/MXPA04009672A/es active IP Right Grant
- 2003-03-21 ES ES03745205T patent/ES2268394T3/es not_active Expired - Lifetime
- 2003-03-31 US US10/403,537 patent/US6878727B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2480583A1 (en) | 2003-10-09 |
| EP1490350A1 (en) | 2004-12-29 |
| BR0308856A (pt) | 2005-02-22 |
| WO2003082848A1 (en) | 2003-10-09 |
| ES2268394T3 (es) | 2007-03-16 |
| MXPA04009672A (es) | 2004-11-12 |
| DE60307804D1 (de) | 2006-10-05 |
| ATE337309T1 (de) | 2006-09-15 |
| US6878727B2 (en) | 2005-04-12 |
| CA2480583C (en) | 2008-07-15 |
| JP2005526102A (ja) | 2005-09-02 |
| EP1490350B1 (en) | 2006-08-23 |
| DE60307804T2 (de) | 2007-01-18 |
| US20030195239A1 (en) | 2003-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60319820D1 (de) | Pyrazoloä1,5-aüpyrimidin-verbindungen als antivirale agentien | |
| UY27798A1 (es) | Inhibidores de la arn polimerasa dependiente de arn del virus de la hepatits c y composiciones y tratamientos que los usan. | |
| EA200501689A1 (ru) | Соединения в качестве ингибиторов вируса гепатита c | |
| IL180933A0 (en) | Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same | |
| YU56903A (sh) | Nukleozidni derivati kao inhibitori rnk-zavisne rnk virusne polimeraze | |
| WO2004000858A3 (en) | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | |
| WO2004003138A3 (en) | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | |
| NO20070194L (no) | Fremgangsmater for behandling av hepatitt C | |
| NO20045247L (no) | Nukleosidderivater for behandling av hepatitt C-virusinfeksjon | |
| NL1025544A1 (nl) | Remmers van rna-afhankelijk rna-polymerase van hepatitis-c-virus en preparaten en behandelingen waarbij ze worden gebruikt. | |
| NO20062428L (no) | Kombinasjoner for HCV-behandling | |
| AU2003215826A1 (en) | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase | |
| EP1663105A4 (en) | CYCLOALKYL HETEROCYCLES FOR TREATING HEPATITIS C VIRUS | |
| WO2006043153A3 (en) | Use of zinc and copper chelators for the treatment of viral diseases | |
| WO2004052905A3 (en) | Antiviral nucleoside derivatives | |
| AU2003287216A1 (en) | Gb virus c and methods of treating viral infections | |
| WO2004006848A3 (en) | Combination therapies with ftc for the treatment of hepatitis b virus infection | |
| TW200614989A (en) | Inhibitors of HCV replication | |
| AU2003299493A8 (en) | Compositions and methods for the treatment of hepatitis c virus infection | |
| HK1065534A (en) | Proline compounds as ns3-serine protease inhibitors for use in treatment of hepatitis c virus infection | |
| HK1068796A (en) | Nucleosides preparation thereof and use as inhibitors of rna viral polymerases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |