AU2002351184A1 - Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy - Google Patents

Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy

Info

Publication number
AU2002351184A1
AU2002351184A1 AU2002351184A AU2002351184A AU2002351184A1 AU 2002351184 A1 AU2002351184 A1 AU 2002351184A1 AU 2002351184 A AU2002351184 A AU 2002351184A AU 2002351184 A AU2002351184 A AU 2002351184A AU 2002351184 A1 AU2002351184 A1 AU 2002351184A1
Authority
AU
Australia
Prior art keywords
confocal microscopy
spectral encoding
spectroscopically
spectroscopically encoded
encoded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002351184A
Other languages
English (en)
Inventor
Brett E. Bouma
Constantinos Pitris
Millen Shishkov
Guillermo J. Tearney
Robert H. Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of AU2002351184A1 publication Critical patent/AU2002351184A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0291—Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/06—Scanning arrangements arrangements for order-selection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J3/14—Generating the spectrum; Monochromators using refracting elements, e.g. prisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J3/18—Generating the spectrum; Monochromators using diffraction elements, e.g. grating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0056—Optical details of the image generation based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2453—Optical details of the proximal end
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/06—Scanning arrangements arrangements for order-selection
    • G01J2003/062—Scanning arrangements arrangements for order-selection motor-driven
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/06—Scanning arrangements arrangements for order-selection
    • G01J2003/064—Use of other elements for scan, e.g. mirror, fixed grating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/06—Scanning arrangements arrangements for order-selection
    • G01J2003/064—Use of other elements for scan, e.g. mirror, fixed grating
    • G01J2003/065—Use of fibre scan for spectral scan
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/06—Scanning arrangements arrangements for order-selection
    • G01J2003/069—Complex motion, e.g. rotation of grating and correcting translation

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Astronomy & Astrophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Endoscopes (AREA)
AU2002351184A 2001-11-29 2002-11-27 Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy Abandoned AU2002351184A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/999,182 US6831781B2 (en) 1998-02-26 2001-11-29 Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
US09/999,182 2001-11-29
PCT/US2002/038335 WO2003046636A1 (en) 2001-11-29 2002-11-27 Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy

Publications (1)

Publication Number Publication Date
AU2002351184A1 true AU2002351184A1 (en) 2003-06-10

Family

ID=25545995

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002351184A Abandoned AU2002351184A1 (en) 2001-11-29 2002-11-27 Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy

Country Status (5)

Country Link
US (1) US6831781B2 (https=)
EP (1) EP1461654A4 (https=)
JP (4) JP2005510323A (https=)
AU (1) AU2002351184A1 (https=)
WO (1) WO2003046636A1 (https=)

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60141090D1 (de) * 2000-10-30 2010-03-04 Gen Hospital Corp Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
EP2333521B1 (en) 2001-04-30 2019-12-04 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US6980299B1 (en) 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
EP2327954A1 (en) * 2002-01-11 2011-06-01 The General Hospital Corporation Apparatus for OCT imaging with axial line focus for improved resolution and depth of field
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
NZ535953A (en) 2002-04-15 2007-02-23 Epos Technologies Ltd Method and system for obtaining positioning data
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
AU2004206998B2 (en) 2003-01-24 2009-12-17 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
JP4338412B2 (ja) * 2003-02-24 2009-10-07 Ｈｏｙａ株式会社 共焦点プローブおよび共焦点顕微鏡
CA2519937C (en) 2003-03-31 2012-11-20 Guillermo J. Tearney Speckle reduction in optical coherence tomography by path length encoded angular compounding
EP2280260B1 (en) 2003-06-06 2017-03-08 The General Hospital Corporation Process and apparatus for a wavelength tuned light source
US7030383B2 (en) * 2003-08-04 2006-04-18 Cadent Ltd. Speckle reduction method and apparatus
JP5567246B2 (ja) 2003-10-27 2014-08-06 ザ ジェネラル ホスピタル コーポレイション 周波数ドメイン干渉測定を利用して光学撮像を実行する方法および装置
JP5214883B2 (ja) 2003-11-28 2013-06-19 ザ ジェネラル ホスピタル コーポレイション 三次元分光的符号化撮像のための方法と装置
FR2864438B1 (fr) * 2003-12-31 2006-11-17 Mauna Kea Technologies Tete optique miniature a balayage integre pour la realisation d'une image confocale homogene, et systeme d'imagerie confocale utilisant ladite tete
JP5243025B2 (ja) 2004-05-17 2013-07-24 エポス ディベロップメント リミテッド 音響測位システムのための頑健な音響同期シグナリング
WO2005117534A2 (en) 2004-05-29 2005-12-15 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
US7852551B2 (en) * 2004-06-14 2010-12-14 Olympus Corporation Optical-scanning microscope examination apparatus
AU2005270037B2 (en) 2004-07-02 2012-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
EP1782020B1 (en) 2004-08-06 2012-10-03 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
WO2006024014A2 (en) 2004-08-24 2006-03-02 The General Hospital Corporation Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample
WO2006024015A1 (en) 2004-08-24 2006-03-02 The General Hospital Corporation Method and apparatus for imaging of vessel segments
JP5215664B2 (ja) 2004-09-10 2013-06-19 ザ ジェネラル ホスピタル コーポレイション 光学コヒーレンス撮像のシステムおよび方法
US8391959B2 (en) 2004-09-29 2013-03-05 Tel Hashomer Medical Research Infrastructure And Services Ltd. Composition for improving efficiency of drug delivery
JP4997112B2 (ja) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション 少なくとも１つの電磁放射を伝送させるための装置およびその製造方法
US9161820B2 (en) 2004-10-28 2015-10-20 Nico Corporation Surgical access assembly and method of using same
JP5623692B2 (ja) 2004-11-02 2014-11-12 ザ ジェネラル ホスピタル コーポレイション 試料の画像形成のための光ファイバ回転装置、光学システム及び方法
EP2278265A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
US8922781B2 (en) 2004-11-29 2014-12-30 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
CN100516841C (zh) * 2004-12-09 2009-07-22 暨南大学 一种可产生明场或宽场荧光光切片的方法
US7367944B2 (en) 2004-12-13 2008-05-06 Tel Hashomer Medical Research Infrastructure And Services Ltd. Method and system for monitoring ablation of tissues
CN101180601B (zh) 2005-03-23 2014-09-17 高通股份有限公司 数字笔和数字笔系统
EP2085929A1 (en) 2005-04-28 2009-08-05 The General Hospital Corporation Evaluating optical coherence tomography information for an anatomical structure
WO2006128442A1 (de) * 2005-05-31 2006-12-07 W.O.M. World Of Medicine Ag Verfahren und vorrichtung zur optischen charakterisierung von gewebe
WO2006130797A2 (en) * 2005-05-31 2006-12-07 The General Hospital Corporation Spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
US7909817B2 (en) * 2005-06-08 2011-03-22 Innovaquartz, Inc. (AMS Research Corporation) Lateral laser fiber for high average power and peak pulse energy
GB0515758D0 (en) * 2005-07-30 2005-09-07 Univ Hospital Of North Staffor Improvements in and relating to optical coherence tomography
ATE484727T1 (de) 2005-08-09 2010-10-15 Gen Hospital Corp Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie
AU2006299659A1 (en) 2005-09-29 2007-04-12 General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
US7889348B2 (en) 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
EP1971848B1 (en) * 2006-01-10 2019-12-04 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
ES2847854T3 (es) 2006-01-19 2021-08-04 Massachusetts Gen Hospital Catéter de globo de obtención de imágenes
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
EP1983921B1 (en) 2006-02-01 2016-05-25 The General Hospital Corporation Systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
US7538859B2 (en) 2006-02-01 2009-05-26 The General Hospital Corporation Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto
JP2009537024A (ja) 2006-02-01 2009-10-22 ザ ジェネラル ホスピタル コーポレイション 少なくとも一つのファイバの少なくとも二つの部位の少なくとも一つを制御する装置
EP3143926B1 (en) 2006-02-08 2020-07-01 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
US7982879B2 (en) 2006-02-24 2011-07-19 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US7742173B2 (en) 2006-04-05 2010-06-22 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
EP3150110B1 (en) 2006-05-10 2020-09-02 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
US7782464B2 (en) 2006-05-12 2010-08-24 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
EP2054712B1 (en) 2006-08-25 2015-10-07 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
WO2008089406A2 (en) 2007-01-19 2008-07-24 The General Hospital Corporation Apparatus and method for simultaneous inspection at different depths based on the principle of frequency domain optical coherence tomography
EP2104968A1 (en) 2007-01-19 2009-09-30 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
AU2008224542B2 (en) 2007-03-14 2012-01-19 Qualcomm Incorporated MEMS microphone
EP2602651A3 (en) 2007-03-23 2014-08-27 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
WO2008121844A1 (en) 2007-03-30 2008-10-09 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
US9181555B2 (en) * 2007-07-23 2015-11-10 Ramot At Tel-Aviv University Ltd. Photocatalytic hydrogen production and polypeptides capable of same
EP2173254A2 (en) 2007-07-31 2010-04-14 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
US8040608B2 (en) 2007-08-31 2011-10-18 The General Hospital Corporation System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith
JP5643101B2 (ja) 2007-10-25 2014-12-17 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 散乱媒体の画像化方法、画像化装置及び画像化システム
WO2009059034A1 (en) 2007-10-30 2009-05-07 The General Hospital Corporation System and method for cladding mode detection
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
EP2274572A4 (en) 2008-05-07 2013-08-28 Gen Hospital Corp SYSTEM, METHOD AND COMPUTER MEDIUM FOR TRACKING A VASCULAR MOVEMENT IN A THREE-DIMENSIONAL CORONARTERTERIC MICROSCOPY
EP2288948A4 (en) 2008-06-20 2011-12-28 Gen Hospital Corp Fused fiber optic coupler arrangement and method for use thereof
WO2010009136A2 (en) 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus and methods for color endoscopy
JP5508416B2 (ja) * 2008-07-24 2014-05-28 ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア ディスパーシブフーリエ変換イメージングの装置および方法
US9687190B2 (en) 2008-07-30 2017-06-27 Vanderbilt University Intra-operative use of fluorescence spectroscopy and applications of same
US8440952B2 (en) 2008-11-18 2013-05-14 The Regents Of The University Of California Methods for optical amplified imaging using a two-dimensional spectral brush
ES2957932T3 (es) 2008-12-10 2024-01-30 Massachusetts Gen Hospital Sistemas, aparatos y procedimientos para ampliar el rango de profundidad de imagen de tomografía de coherencia óptica mediante submuestreo óptico
US9351705B2 (en) 2009-01-09 2016-05-31 Washington University Miniaturized photoacoustic imaging apparatus including a rotatable reflector
JP2012515576A (ja) * 2009-01-20 2012-07-12 ザ ジェネラル ホスピタル コーポレイション 内視鏡生検装置、システム、及び方法
JP2012515930A (ja) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
CN104134928A (zh) 2009-02-04 2014-11-05 通用医疗公司 利用高速光学波长调谐源的设备和方法
WO2010105197A2 (en) 2009-03-12 2010-09-16 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s)
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
JP6210682B2 (ja) * 2009-09-14 2017-10-11 メモリアル スローン−ケタリング キャンサー センター 低侵襲手術における組織の切開、切除およびアブレーションのためのレーザー・ステアリングおよびフォーカシングを提供する装置、システムおよび方法
WO2011044301A2 (en) * 2009-10-06 2011-04-14 The General Hospital Corporation Apparatus and methods for imaging particular cells including eosinophils
WO2011136857A2 (en) * 2010-01-06 2011-11-03 Trustees Of Boston University Correlation confocal microscope
HRP20201813T1 (hr) 2010-03-05 2021-03-19 The General Hospital Corporation Uređaj za pružanje elektromagnetnog zračenja na uzorak
WO2011127428A2 (en) 2010-04-09 2011-10-13 Washington University Quantification of optical absorption coefficients using acoustic spectra in photoacoustic tomography
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2575597B1 (en) 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
WO2011150069A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
EP4238492A3 (en) 2010-05-28 2023-09-27 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for analyzing information regarding cardiovascular disease(s) and function(s)
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
JP5541972B2 (ja) * 2010-06-09 2014-07-09 オリンパス株式会社 走査型共焦点顕微鏡
EP2632324A4 (en) 2010-10-27 2015-04-22 Gen Hospital Corp DEVICES, SYSTEMS AND METHOD FOR MEASURING BLOOD PRESSURE IN AT LEAST ONE VESSEL
US9063074B2 (en) * 2010-12-30 2015-06-23 Empire Technology Development Llc Analyzing tissue morphology in three dimensions
US8997572B2 (en) 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
WO2012149175A1 (en) 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
WO2013029047A1 (en) 2011-08-25 2013-02-28 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
US20140336990A1 (en) * 2011-11-24 2014-11-13 National University Corporation Tokyo University Of Agriculture And Technology Measurement device and measurement method
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
EP2852315A4 (en) 2012-05-21 2016-06-08 Gen Hospital Corp DEVICE, APPARATUS AND METHOD FOR CAPSULE MICROSCOPY
JP6227652B2 (ja) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体
US11020006B2 (en) 2012-10-18 2021-06-01 California Institute Of Technology Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
EP2948758B1 (en) 2013-01-28 2024-03-13 The General Hospital Corporation Apparatus for providing diffuse spectroscopy co-registered with optical frequency domain imaging
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
WO2014144709A2 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Methods and systems for characterizing an object
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
US9562860B1 (en) 2013-06-19 2017-02-07 Theranos, Inc. Methods and devices for sample analysis
EP3692887B1 (en) 2013-07-19 2024-03-06 The General Hospital Corporation Imaging apparatus which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
EP3910282B1 (en) 2013-07-26 2024-01-17 The General Hospital Corporation Method of providing a laser radiation with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography
WO2015077355A1 (en) 2013-11-19 2015-05-28 Washington University Systems and methods of grueneisen-relaxation photoacoustic microscopy and photoacoustic wavefront shaping
TWI533834B (zh) * 2013-12-10 2016-05-21 Ying-Jie Su Magnetic manipulation of the surgical lighting device and a hand with a lighting function Assisted system
WO2015105850A1 (en) 2014-01-07 2015-07-16 The General Hospital Corporation Method and apparatus for recording microscopic images from within a living organism using an implantable device
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
KR101850640B1 (ko) 2014-01-31 2018-04-19 캐논 유.에스.에이. 인코포레이티드 컬러 내시경을 위한 장치 및 방법
WO2015116951A2 (en) 2014-01-31 2015-08-06 Canon U.S.A., Inc. Optical probe, light intensity detection, imaging method and system
EP4487773A3 (en) 2014-01-31 2025-01-15 The General Hospital Corporation Method and apparatus for performing multidimensional velocity measurements based on amplitude and phase signals in the field of optical interferometry
US10130259B2 (en) 2014-02-05 2018-11-20 British Columbia Cancer Agency Branch Systems for optical imaging of biological tissues
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
KR101476820B1 (ko) * 2014-04-07 2014-12-29 주식회사 썸텍 3ｄ 비디오 현미경 장치
US10912462B2 (en) 2014-07-25 2021-02-09 The General Hospital Corporation Apparatus, devices and methods for in vivo imaging and diagnosis
US10959712B2 (en) * 2015-03-10 2021-03-30 The General Hospital Corporation Apparatus, method and computer-accessible medium for obtaining tissue sample
WO2017002535A1 (ja) * 2015-06-29 2017-01-05 国立大学法人徳島大学 計測装置
WO2017024145A1 (en) 2015-08-05 2017-02-09 Canon U.S.A., Inc. Forward and angle view endoscope
WO2017024234A1 (en) 2015-08-05 2017-02-09 Canon U.S.A., Inc. Endoscope probes and systems, and methods for use therewith
US11131860B1 (en) * 2015-09-14 2021-09-28 Wavefront Research, Inc. Wide spatial field optical systems
WO2017049085A1 (en) 2015-09-16 2017-03-23 The General Hospital Corporation Apparatus and methods for mirror tunnel imaging device and for providing pseudo-bessel beams in a miniaturized optical system for imaging
US9784619B2 (en) * 2015-10-13 2017-10-10 Beijing Information Science & Technology University Fiber grating demodulation system for enhancing spectral resolution of detector array
US9869588B2 (en) * 2015-10-13 2018-01-16 Beijing Information Science & Technology University Fiber grating demodulation system for enhancing spectral resolution by finely shifting slit
US9784618B2 (en) * 2015-10-14 2017-10-10 Beijing Information Science & Technology University Fiber grating demodulation system for enhancing spectral resolution by finely rotating light splitting grating
US9869587B2 (en) * 2015-10-14 2018-01-16 Bejing Information Science & Technology University Fiber grating demodulation system for enhancing spectral resolution by finely shifting linear array detector
JP6570427B2 (ja) * 2015-11-06 2019-09-04 浜松ホトニクス株式会社 画像取得装置、画像取得方法、及び空間光変調ユニット
JP6448055B2 (ja) 2015-11-09 2019-01-09 富士フイルム株式会社 超音波内視鏡及び超音波内視鏡の製造方法
JP6649044B2 (ja) * 2015-11-10 2020-02-19 富士フイルム株式会社 超音波内視鏡及び超音波内視鏡の製造方法
US10451479B2 (en) * 2015-11-11 2019-10-22 The Curators Of The University Of Missouri Multichannel ultra-sensitive optical spectroscopic detection
US9869854B2 (en) 2015-12-16 2018-01-16 Canon U.S.A, Inc. Endoscopic system
WO2017117203A1 (en) 2015-12-28 2017-07-06 Canon U.S.A., Inc. Optical probe, light intensity detection, imaging method and system
CN119756163A (zh) 2016-02-12 2025-04-04 通用医疗公司 用于使用光学相干断层成像进行高速和长深度范围成像的装置和方法
WO2017139657A1 (en) 2016-02-12 2017-08-17 Canon U.S.A., Inc. Simple monolithic optical element for forward-viewing spectrally encoded endoscopy
US10321810B2 (en) 2016-06-13 2019-06-18 Canon U.S.A., Inc. Spectrally encoded endoscopic probe having a fixed fiber
KR102560803B1 (ko) 2016-07-05 2023-07-31 더 제너럴 하스피탈 코포레이션 능동적으로 제어되는 광학 이미징 장치를 위한 시스템들 및 방법들
JP2019527576A (ja) 2016-07-15 2019-10-03 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc スペクトル符号化プローブ
US10401610B2 (en) 2016-07-15 2019-09-03 Canon Usa, Inc. Spectrally encoded probe with multiple diffraction orders
JP2019534069A (ja) 2016-09-23 2019-11-28 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc スペクトル符号化内視鏡検査装置および方法
US10898068B2 (en) 2016-11-01 2021-01-26 Canon U.S.A., Inc. Multi-bandwidth spectrally encoded endoscope
JP2018094395A (ja) 2016-11-03 2018-06-21 キヤノン ユーエスエイ, インコーポレイテッドCanon U.S.A., Inc 診断用スペクトル符号化内視鏡検査装置およびシステム、ならびにこれらと共に使用するための方法
US10222607B2 (en) 2016-12-14 2019-03-05 Canon U.S.A., Inc. Three-dimensional endoscope
US10989517B2 (en) 2016-12-22 2021-04-27 ContinUse Biometrics Ltd. Vibration sensing system with wavelength encoding
EP3602003B1 (en) 2017-03-31 2026-04-22 Life Technologies Corporation Apparatuses, systems and methods for imaging flow cytometry
US11672426B2 (en) 2017-05-10 2023-06-13 California Institute Of Technology Snapshot photoacoustic photography using an ergodic relay
US10825152B2 (en) 2017-09-14 2020-11-03 Canon U.S.A., Inc. Distortion measurement and correction for spectrally encoded endoscopy
EP3722787B1 (en) * 2017-12-07 2024-03-27 Yokogawa Electric Corporation Spectroscopic analyzer
US11530979B2 (en) 2018-08-14 2022-12-20 California Institute Of Technology Multifocal photoacoustic microscopy through an ergodic relay
WO2020051246A1 (en) 2018-09-04 2020-03-12 California Institute Of Technology Enhanced-resolution infrared photoacoustic microscopy and spectroscopy
EP3637167B1 (en) * 2018-10-11 2024-12-04 Baden-Württemberg Stiftung gGmbH Area scanning confocal microscopy (ascm)
US11369280B2 (en) 2019-03-01 2022-06-28 California Institute Of Technology Velocity-matched ultrasonic tagging in photoacoustic flowgraphy
US11441948B2 (en) * 2019-03-25 2022-09-13 Mks Technology, Inc. Multi-dispersive spectrometer
JP7413512B2 (ja) 2019-08-27 2024-01-15 ザ ジェネラル ホスピタル コーポレイション 高分解能高速カプセル内視鏡のためのシステム及び方法
US11986269B2 (en) 2019-11-05 2024-05-21 California Institute Of Technology Spatiotemporal antialiasing in photoacoustic computed tomography
EP4337081A4 (en) 2021-05-14 2025-04-16 Leadoptik Inc. Methods and apparatus for reconfigurable optical endoscopic catheter
US20240350015A1 (en) 2021-08-16 2024-10-24 Spectrawave, Inc. Multi modality rotary optical systems and methods of their use
US12504363B2 (en) 2021-08-17 2025-12-23 California Institute Of Technology Three-dimensional contoured scanning photoacoustic imaging and virtual staining
US12593986B2 (en) 2023-04-12 2026-04-07 California Institute Of Technology Transmission mode-photoacoustic tomography of the human brain through an acoustic window
FR3151410A1 (fr) * 2023-07-20 2025-01-24 Framatome Dispositif de balayage endoscopique sans déplacement mécanique, ensemble et procédé associés

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2626383B1 (fr) 1988-01-27 1991-10-25 Commissariat Energie Atomique Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US6111645A (en) 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
US5248876A (en) 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
US5698397A (en) 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
DE69325783T2 (de) * 1992-12-11 1999-11-18 Raytheon Co., El Segundo Achromatisches und apochromatisches Prismenelement aus Prisma und Gittern
EP0602992B1 (en) * 1992-12-18 1999-03-03 Raytheon Company Grating-prism combination
US5450203A (en) 1993-12-22 1995-09-12 Electroglas, Inc. Method and apparatus for determining an objects position, topography and for imaging
DE4411017C2 (de) 1994-03-30 1995-06-08 Alexander Dr Knuettel Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US5600486A (en) 1995-01-30 1997-02-04 Lockheed Missiles And Space Company, Inc. Color separation microlens
US5526338A (en) 1995-03-10 1996-06-11 Yeda Research & Development Co. Ltd. Method and apparatus for storage and retrieval with multilayer optical disks
US5785651A (en) 1995-06-07 1998-07-28 Keravision, Inc. Distance measuring confocal microscope
US5742419A (en) * 1995-11-07 1998-04-21 The Board Of Trustees Of The Leland Stanford Junior Universtiy Miniature scanning confocal microscope
DE19640495C2 (de) * 1996-10-01 1999-12-16 Leica Microsystems Vorrichtung zur konfokalen Oberflächenvermessung
JP2001515382A (ja) * 1997-03-06 2001-09-18 マサチューセッツ インスティチュート オブ テクノロジー 生体組織の光学走査用機器
US5887009A (en) * 1997-05-22 1999-03-23 Optical Biopsy Technologies, Inc. Confocal optical scanning system employing a fiber laser
EP2267507A3 (en) * 1998-02-26 2011-08-17 The General Hospital Corporation Confocal microscopy with multi-spectral encoding
RU2148378C1 (ru) * 1998-03-06 2000-05-10 Геликонов Валентин Михайлович Устройство для оптической когерентной томографии, оптоволоконное сканирующее устройство и способ диагностики биоткани in vivo
US6166373A (en) 1998-07-21 2000-12-26 The Institute For Technology Development Focal plane scanner with reciprocating spatial window
FR2783330B1 (fr) * 1998-09-15 2002-06-14 Assist Publ Hopitaux De Paris Dispositif d'observation de l'interieur d'un corps produisant une qualite d'observation perfectionnee
JP2000121961A (ja) * 1998-10-13 2000-04-28 Olympus Optical Co Ltd 共焦点光走査プローブシステム
JP2000292703A (ja) * 1999-04-02 2000-10-20 Olympus Optical Co Ltd 共焦点光学装置
JP2001174744A (ja) * 1999-10-06 2001-06-29 Olympus Optical Co Ltd 光走査プローブ装置
JP2001149305A (ja) * 1999-11-29 2001-06-05 Olympus Optical Co Ltd 光走査プローブ装置
JP2001327460A (ja) * 2000-05-18 2001-11-27 Olympus Optical Co Ltd 内視鏡装置
JP4460117B2 (ja) 2000-06-29 2010-05-12 独立行政法人理化学研究所 グリズム
DE10331906B4 (de) * 2003-07-15 2005-06-16 Leica Microsystems Heidelberg Gmbh Lichtquelle mit einem Mikrostruktuierten optischen Element und Mikroskop mit Lichtquelle

Also Published As

Publication number Publication date
US20020122246A1 (en) 2002-09-05
WO2003046636A9 (en) 2004-02-26
JP2013056165A (ja) 2013-03-28
WO2003046636A1 (en) 2003-06-05
JP2005510323A (ja) 2005-04-21
JP2010107519A (ja) 2010-05-13
EP1461654A4 (en) 2013-10-02
JP6098953B2 (ja) 2017-03-22
JP2015157073A (ja) 2015-09-03
US6831781B2 (en) 2004-12-14
EP1461654A1 (en) 2004-09-29

Similar Documents

Publication Publication Date Title
AU2002351184A1 (en) Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
AU2002337253A1 (en) Composite fibre reforming method and uses
AU2002350279A1 (en) Document display system and method
AU2002366078A1 (en) Vehicle security and maintenance
AU2002357349A1 (en) Multimodal communication method and apparatus with multimodal profile
AU2002254280A1 (en) Adjustable scalable rack power system and method
IL157668A0 (en) Optical devices and methods employing nanoparticles, microcavities, and semicontinuous metal films
AU2002250858A1 (en) Capsule-in-capsule system and method for the production thereof
AU2002346585A1 (en) System and methods for efficient quantization
AU2002319029A1 (en) Composite document editor
AU2002248476A1 (en) Optimized defects in phonotic band-gap waveguides
AU2002343522A1 (en) Linear imager rescaling method
GB0118981D0 (en) Electron microscope and spectroscopy system
HU0400294V0 (en) Individual means for producing oxygen cocktail and the oxygen cylinder therefor
AU2002234215A1 (en) Liquid colorant and method
AU2002325843A1 (en) Method for determining the interaction between keratinocytes and neurons
GB0103905D0 (en) Security document and method for its manufacture
AU2002336529A1 (en) Protein modification and maintenance molecules
AU2002258724A1 (en) Protein modification and maintenance molecules
AU2002338867A1 (en) Multilayer security document and method for the production thereof
AU2001264226A1 (en) Composite light dispersion for compensating device and method for compensating light dispersion using the device
AU2002255006A1 (en) Value document and method for the production thereof
AU2002338911A1 (en) Lipoprotein creams with uv filters
AU2002252834A1 (en) Personal document system and method
AU2002362347A1 (en) Optical fingerprint acquisition apparatus

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase