AU2002335808B2 - Affinity enhancement agents - Google Patents
Affinity enhancement agents Download PDFInfo
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- AU2002335808B2 AU2002335808B2 AU2002335808A AU2002335808A AU2002335808B2 AU 2002335808 B2 AU2002335808 B2 AU 2002335808B2 AU 2002335808 A AU2002335808 A AU 2002335808A AU 2002335808 A AU2002335808 A AU 2002335808A AU 2002335808 B2 AU2002335808 B2 AU 2002335808B2
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- binding protein
- polypeptide
- diabody
- binding
- hmn14
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Zoology (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
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| US32883501P | 2001-10-15 | 2001-10-15 | |
| US60/328,835 | 2001-10-15 | ||
| US34188101P | 2001-12-21 | 2001-12-21 | |
| US60/341,881 | 2001-12-21 | ||
| PCT/US2002/032717 WO2003033653A2 (en) | 2001-10-15 | 2002-10-15 | Affinity enhancement agents |
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| AU2002335808A1 AU2002335808A1 (en) | 2003-07-03 |
| AU2002335808B2 true AU2002335808B2 (en) | 2009-08-27 |
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| EP (1) | EP1444267B1 (enExample) |
| JP (1) | JP4443923B2 (enExample) |
| KR (1) | KR101027889B1 (enExample) |
| CN (1) | CN1604910A (enExample) |
| AU (1) | AU2002335808B2 (enExample) |
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| CA (1) | CA2463616C (enExample) |
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| RU (1) | RU2004114878A (enExample) |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US6346454B1 (en) * | 1999-01-12 | 2002-02-12 | Agere Systems Guardian Corp. | Method of making dual damascene interconnect structure and metal electrode capacitor |
| US20040018557A1 (en) * | 2002-03-01 | 2004-01-29 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
| EP1618181B1 (en) * | 2003-04-22 | 2014-10-15 | IBC Pharmaceuticals | Polyvalent protein complex |
| KR20060041205A (ko) * | 2003-07-01 | 2006-05-11 | 이뮤노메딕스, 인코오포레이티드 | 양특이성 항체들의 다가 담체들 |
| EP3332808B1 (en) | 2005-03-03 | 2020-09-09 | Immunomedics Inc. | Humanized l243 antibodies |
| ES2613844T3 (es) | 2008-04-21 | 2017-05-26 | Lawrence Livermore National Security, Llc | Ligandos polidentados de alta afinidad selectivos y métodos para producirlos |
| WO2011003780A1 (en) * | 2009-07-06 | 2011-01-13 | F. Hoffmann-La Roche Ag | Bi-specific digoxigenin binding antibodies |
| US9264453B2 (en) | 2013-11-08 | 2016-02-16 | At&T Mobility Ii Llc | Front end processor for short message service centers |
| KR20250150051A (ko) * | 2023-03-03 | 2025-10-17 | 온코원 리서치 앤드 디벨롭먼트 게엠베하 | 과증식성 질환의 예비 표적화를 위한 개선된 이중특이적 항종양 항원/항hsg 항체 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256395A (en) * | 1986-09-19 | 1993-10-26 | Immunotech Partners | Affinity enhancement immunological reagents for in vivo detection and killing of specific target cells |
| US5837242A (en) * | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US6027725A (en) * | 1991-11-25 | 2000-02-22 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US6096289A (en) * | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
| WO1994007921A1 (en) * | 1992-09-25 | 1994-04-14 | Commonwealth Scientific And Industrial Research Organisation | Target binding polypeptide |
| US5874540A (en) * | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
| BR9606706A (pt) * | 1995-10-16 | 1999-04-06 | Unilever Nv | Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo |
| CA2249320C (en) * | 1996-03-20 | 2008-12-23 | Immunomedics, Inc. | Glycosylated humanized b-cell specific antibodies |
| ES2225961T3 (es) * | 1996-04-04 | 2005-03-16 | Unilever N.V. | Proteina de union a antigeno multivalente y multiespecifica. |
| JP4113670B2 (ja) * | 1998-06-22 | 2008-07-09 | イムノメディクス， インコーポレイテッド | プレターゲッティング診断およびプレターゲッティング治療のための二重特異性抗体の使用 |
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US20030162709A1 (en) * | 2001-12-26 | 2003-08-28 | Edmund Rossi | Methods of generating multispecific, multivalent agents from VH and VL domains |
-
2002
- 2002-10-15 CN CNA028250710A patent/CN1604910A/zh active Pending
- 2002-10-15 WO PCT/US2002/032717 patent/WO2003033653A2/en not_active Ceased
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- 2002-10-15 BR BRPI0213284-2A patent/BR0213284A/pt not_active IP Right Cessation
- 2002-10-15 KR KR1020047005675A patent/KR101027889B1/ko not_active Expired - Fee Related
- 2002-10-15 PL PL02374426A patent/PL374426A1/xx unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256395A (en) * | 1986-09-19 | 1993-10-26 | Immunotech Partners | Affinity enhancement immunological reagents for in vivo detection and killing of specific target cells |
| US5837242A (en) * | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
Non-Patent Citations (1)
| Title |
|---|
| Hillairet de Boisferon et a1., (2000) Bioconjugate Chem. Vol. 11, pp. 452-60 * |
Also Published As
| Publication number | Publication date |
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| CA2463616C (en) | 2011-07-12 |
| WO2003033653A3 (en) | 2003-11-13 |
| KR20050036873A (ko) | 2005-04-20 |
| US20030113333A1 (en) | 2003-06-19 |
| WO2003033653B1 (en) | 2004-02-12 |
| KR101027889B1 (ko) | 2011-04-07 |
| RU2004114878A (ru) | 2005-04-20 |
| PL374426A1 (en) | 2005-10-17 |
| EP1444267A2 (en) | 2004-08-11 |
| JP2005518344A (ja) | 2005-06-23 |
| WO2003033653A2 (en) | 2003-04-24 |
| CN1604910A (zh) | 2005-04-06 |
| JP4443923B2 (ja) | 2010-03-31 |
| EP1444267B1 (en) | 2016-08-10 |
| BR0213284A (pt) | 2006-05-23 |
| CA2463616A1 (en) | 2003-04-24 |
| MXPA04003533A (es) | 2005-06-20 |
| EP1444267A4 (en) | 2009-12-02 |
| IL161417A0 (en) | 2004-09-27 |
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