AU2002330088B2 - Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy - Google Patents
Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy Download PDFInfo
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- AU2002330088B2 AU2002330088B2 AU2002330088A AU2002330088A AU2002330088B2 AU 2002330088 B2 AU2002330088 B2 AU 2002330088B2 AU 2002330088 A AU2002330088 A AU 2002330088A AU 2002330088 A AU2002330088 A AU 2002330088A AU 2002330088 B2 AU2002330088 B2 AU 2002330088B2
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- suramin
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- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 title claims description 340
- 229960005314 suramin Drugs 0.000 title claims description 339
- 238000000034 method Methods 0.000 title claims description 69
- 230000003034 chemosensitisation Effects 0.000 title description 40
- 238000002648 combination therapy Methods 0.000 title description 6
- 239000000203 mixture Substances 0.000 title description 4
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- 238000011282 treatment Methods 0.000 claims description 76
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Landscapes
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| PCT/US2002/030210 WO2003026574A2 (en) | 2001-09-24 | 2002-09-24 | Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy |
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| US6982253B2 (en) | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| WO2007065016A2 (en) * | 2005-12-02 | 2007-06-07 | Au Jessie L S | Methods and compositions to improve activity and reduce toxicity of stents |
| KR20150091434A (ko) * | 2007-07-30 | 2015-08-10 | 아디아 바이오사이언스즈 인크. | 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법 |
| US9381207B2 (en) | 2011-08-30 | 2016-07-05 | Astex Pharmaceuticals, Inc. | Drug formulations |
| CN104398517A (zh) * | 2014-11-28 | 2015-03-11 | 四川大学 | 乙胺嘧啶的新用途及治疗肿瘤的药物组合物 |
| CA2991167A1 (en) | 2015-07-02 | 2017-01-05 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
| TW201718598A (zh) * | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| CA3071755A1 (en) | 2017-08-03 | 2019-02-07 | Otsuka Pharmaceutical Co., Ltd. | Drug compound and purification methods thereof |
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| US5597830A (en) * | 1994-12-20 | 1997-01-28 | Warner-Lambert Company | Combination chemotherapy |
| KR20040097250A (ko) * | 1996-05-24 | 2004-11-17 | 유니버시티 오브 브리티시 콜롬비아 | 신체 통로의 질병을 치료 또는 예방하기 위한 조성물 및방법 |
| KR100417612B1 (ko) * | 1997-03-11 | 2004-02-05 | 레 라보라뚜와르 제떼르나 인코오포레이티드 | 상어 연골 추출물 및 항신생물제를 포함하는 암치료용 조성물 |
| US6506783B1 (en) * | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| AU780454B2 (en) * | 1999-06-03 | 2005-03-24 | Jessie L.S. Au | Methods and compositions for modulating cell proliferation and cell death |
| US6420378B1 (en) * | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
-
2002
- 2002-09-24 JP JP2003530213A patent/JP2005508322A/ja active Pending
- 2002-09-24 IL IL16103602A patent/IL161036A0/xx unknown
- 2002-09-24 AU AU2002330088A patent/AU2002330088B2/en not_active Ceased
- 2002-09-24 CN CNB028228731A patent/CN100441176C/zh not_active Expired - Fee Related
- 2002-09-24 CA CA2461227A patent/CA2461227C/en not_active Expired - Fee Related
- 2002-09-24 KR KR10-2004-7004199A patent/KR20040062546A/ko not_active Ceased
- 2002-09-24 WO PCT/US2002/030210 patent/WO2003026574A2/en not_active Ceased
- 2002-09-24 EP EP02766346A patent/EP1429713A4/en not_active Withdrawn
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2004
- 2004-03-24 US US10/807,620 patent/US20040180955A1/en not_active Abandoned
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2011
- 2011-02-21 US US13/031,306 patent/US8580857B2/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Song S. et al. Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases. Cancer Research, 15 August 2001. vol. 61, pages 6145-6150.. * |
| Tu, S. et al. Phase I study of suramin combined with doxorubicin in the treatment of androgen-independent prostate cancer. Clinical Cancer Research, May 1998. vol. 4, pages 1193-1201. * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003026574A3 (en) | 2004-04-15 |
| WO2003026574A2 (en) | 2003-04-03 |
| CA2461227C (en) | 2012-05-15 |
| CN100441176C (zh) | 2008-12-10 |
| IL161036A0 (en) | 2004-08-31 |
| EP1429713A4 (en) | 2007-08-08 |
| JP2005508322A (ja) | 2005-03-31 |
| KR20040062546A (ko) | 2004-07-07 |
| CA2461227A1 (en) | 2003-04-03 |
| EP1429713A2 (en) | 2004-06-23 |
| US8580857B2 (en) | 2013-11-12 |
| CN1589138A (zh) | 2005-03-02 |
| HK1074167A1 (zh) | 2005-11-04 |
| US20040180955A1 (en) | 2004-09-16 |
| US20110142794A1 (en) | 2011-06-16 |
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