AU2002234175A1 - Use of a helminth for the in vivo delivery of a medicament - Google Patents
Use of a helminth for the in vivo delivery of a medicamentInfo
- Publication number
- AU2002234175A1 AU2002234175A1 AU2002234175A AU3417502A AU2002234175A1 AU 2002234175 A1 AU2002234175 A1 AU 2002234175A1 AU 2002234175 A AU2002234175 A AU 2002234175A AU 3417502 A AU3417502 A AU 3417502A AU 2002234175 A1 AU2002234175 A1 AU 2002234175A1
- Authority
- AU
- Australia
- Prior art keywords
- helminth
- host
- nucleic acid
- bioactive agent
- male
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 244000000013 helminth Species 0.000 title claims description 64
- 108010034145 Helminth Proteins Proteins 0.000 title claims description 52
- 239000003814 drug Substances 0.000 title description 5
- 238000001727 in vivo Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims description 43
- 239000012867 bioactive agent Substances 0.000 claims description 37
- 108020004707 nucleic acids Proteins 0.000 claims description 37
- 102000039446 nucleic acids Human genes 0.000 claims description 37
- 150000007523 nucleic acids Chemical class 0.000 claims description 37
- 241000242678 Schistosoma Species 0.000 claims description 29
- 230000002459 sustained effect Effects 0.000 claims description 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
- 229920001184 polypeptide Polymers 0.000 claims description 19
- 238000012377 drug delivery Methods 0.000 claims description 17
- 230000000975 bioactive effect Effects 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
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- 206010012601 diabetes mellitus Diseases 0.000 claims description 6
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- 208000009292 Hemophilia A Diseases 0.000 claims description 5
- 241000237858 Gastropoda Species 0.000 claims description 4
- 241001465677 Ancylostomatoidea Species 0.000 claims description 3
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- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
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- 241000244185 Ascaris lumbricoides Species 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24811300P | 2000-11-13 | 2000-11-13 | |
| US60/248,113 | 2000-11-13 | ||
| PCT/US2001/051212 WO2002038752A2 (en) | 2000-11-13 | 2001-11-13 | Use of a helminth for the in vivo delivery of a medicament |
| US10/008,340 | 2001-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002234175A1 true AU2002234175A1 (en) | 2002-05-21 |
Family
ID=22937722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002234175A Abandoned AU2002234175A1 (en) | 2000-11-13 | 2001-11-13 | Use of a helminth for the in vivo delivery of a medicament |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20020090363A1 (de) |
| EP (1) | EP1335749A2 (de) |
| AU (1) | AU2002234175A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015095483A1 (en) * | 2013-12-18 | 2015-06-25 | Helminth, Inc. | Modified helminth |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020144A (en) * | 1996-09-12 | 2000-02-01 | Symbiontics, Inc. | Sustained delivery device comprising a Leishmania protozoa and methods of making and using the same |
-
2001
- 2001-11-13 US US10/008,340 patent/US20020090363A1/en not_active Abandoned
- 2001-11-13 AU AU2002234175A patent/AU2002234175A1/en not_active Abandoned
- 2001-11-13 EP EP01985205A patent/EP1335749A2/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20020090363A1 (en) | 2002-07-11 |
| EP1335749A2 (de) | 2003-08-20 |
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