AU2001294258A1 - Method of purifying plavastatin - Google Patents

Method of purifying plavastatin

Info

Publication number
AU2001294258A1
AU2001294258A1 AU2001294258A AU9425801A AU2001294258A1 AU 2001294258 A1 AU2001294258 A1 AU 2001294258A1 AU 2001294258 A AU2001294258 A AU 2001294258A AU 9425801 A AU9425801 A AU 9425801A AU 2001294258 A1 AU2001294258 A1 AU 2001294258A1
Authority
AU
Australia
Prior art keywords
plavastatin
purifying
purifying plavastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001294258A
Other languages
English (en)
Inventor
Minoru Hagisawa
Kiyoshi Hamano
Shunshi Kojima
Nobunari Sugio
Mutsuo Suzuki
Yasuyuki Takamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18794392&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001294258(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of AU2001294258A1 publication Critical patent/AU2001294258A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2001294258A 2000-10-16 2001-10-15 Method of purifying plavastatin Abandoned AU2001294258A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000315256A JP3236282B1 (ja) 2000-10-16 2000-10-16 プラバスタチンを精製する方法
JP2000-315256 2000-10-16
PCT/JP2001/009045 WO2002032848A1 (fr) 2000-10-16 2001-10-15 Procede de purification de pravastatine

Publications (1)

Publication Number Publication Date
AU2001294258A1 true AU2001294258A1 (en) 2002-04-29

Family

ID=18794392

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001294258A Abandoned AU2001294258A1 (en) 2000-10-16 2001-10-15 Method of purifying plavastatin

Country Status (19)

Country Link
US (1) US20030216596A1 (cs)
EP (4) EP1522589A1 (cs)
JP (1) JP3236282B1 (cs)
KR (1) KR20030042018A (cs)
CN (4) CN1868996A (cs)
AU (1) AU2001294258A1 (cs)
BR (1) BR0114681A (cs)
CA (1) CA2425883A1 (cs)
CZ (1) CZ20031052A3 (cs)
HU (1) HUP0303106A3 (cs)
IL (1) IL155360A0 (cs)
MX (1) MXPA03003347A (cs)
NO (1) NO20031739L (cs)
NZ (3) NZ536891A (cs)
PL (1) PL360934A1 (cs)
RU (2) RU2260582C2 (cs)
SK (1) SK4532003A3 (cs)
WO (1) WO2002032848A1 (cs)
ZA (1) ZA200302966B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
TW589178B (en) * 2003-02-21 2004-06-01 China Chemical & Pharmaceutica A novel industrial process to obtain pravastatin sodium of high purity
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
BRPI0513082A (pt) * 2004-08-06 2008-04-22 Transform Pharmaceuticals Inc formulações de fenofibrato e métodos de tratamento relacionados
AU2005271413A1 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel statin pharmaceutical compositions and related methods of treatment
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
CN100361954C (zh) * 2005-05-16 2008-01-16 天津市冠东科技有限公司 制备普伐他汀结晶体的干燥方法
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
WO2010051502A2 (en) * 2008-10-31 2010-05-06 Biogen Idec Ma Inc. Light targeting molecules and uses thereof
CN109796333B (zh) * 2019-01-25 2021-04-09 北大方正集团有限公司 一种从发酵液中提取纯化普伐他汀钠的方法
CN112778120B (zh) * 2019-11-08 2024-05-17 上海现代制药股份有限公司 一种降血脂类药物氧化杂质的制备方法
CN119915920A (zh) * 2023-10-31 2025-05-02 上海现代制药股份有限公司 普伐他汀有关物质的检测方法
CN119915919A (zh) * 2023-10-31 2025-05-02 上海现代制药股份有限公司 普伐他汀有关物质的检测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN1078583C (zh) * 1995-08-03 2002-01-30 普拉斯化学有限公司 酰化化合物脱酰用的选择性方法
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20072A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
JP2000279174A (ja) 1999-03-30 2000-10-10 Bml Inc ヒトｌｄｌレセプターに対するモノクローナル抗体及びこれを用いる家族性高脂血症の判定方法
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
CA2422744A1 (en) * 2000-10-05 2002-04-18 Biogal Gyogyszergyar Rt. Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Also Published As

Publication number Publication date
JP2002121174A (ja) 2002-04-23
NO20031739L (no) 2003-06-13
CN1868996A (zh) 2006-11-29
RU2005113661A (ru) 2006-11-10
KR20030042018A (ko) 2003-05-27
IL155360A0 (en) 2003-11-23
CN1481353A (zh) 2004-03-10
SK4532003A3 (en) 2003-10-07
NO20031739D0 (no) 2003-04-15
NZ525256A (en) 2005-01-28
PL360934A1 (en) 2004-09-20
CZ20031052A3 (cs) 2003-09-17
WO2002032848A1 (fr) 2002-04-25
JP3236282B1 (ja) 2001-12-10
NZ536891A (en) 2005-05-27
CN1690037A (zh) 2005-11-02
HUP0303106A3 (en) 2004-10-28
EP1327626A1 (en) 2003-07-16
EP1522589A1 (en) 2005-04-13
MXPA03003347A (es) 2003-06-19
HUP0303106A2 (hu) 2003-12-29
NZ536892A (en) 2005-05-27
RU2260582C2 (ru) 2005-09-20
US20030216596A1 (en) 2003-11-20
CN1679535A (zh) 2005-10-12
ZA200302966B (en) 2004-07-15
EP1327626A4 (en) 2004-08-18
EP1514863A1 (en) 2005-03-16
BR0114681A (pt) 2003-12-09
CA2425883A1 (en) 2003-04-15
EP1514862A1 (en) 2005-03-16

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