AU2001282829A1 - Amidine derivatives which are inhibitors of nitric oxide synthase - Google Patents

Amidine derivatives which are inhibitors of nitric oxide synthase

Info

Publication number
AU2001282829A1
AU2001282829A1 AU2001282829A AU8282901A AU2001282829A1 AU 2001282829 A1 AU2001282829 A1 AU 2001282829A1 AU 2001282829 A AU2001282829 A AU 2001282829A AU 8282901 A AU8282901 A AU 8282901A AU 2001282829 A1 AU2001282829 A1 AU 2001282829A1
Authority
AU
Australia
Prior art keywords
inhibitors
nitric oxide
oxide synthase
amidine derivatives
amidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282829A
Other languages
English (en)
Inventor
Deborah Chen
James Empfield
Kenneth Mattes
Robert Murray
Eifion Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0021705A external-priority patent/GB0021705D0/en
Priority claimed from GB0021706A external-priority patent/GB0021706D0/en
Priority claimed from SE0102156A external-priority patent/SE0102156D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2001282829A1 publication Critical patent/AU2001282829A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001282829A 2000-09-05 2001-08-30 Amidine derivatives which are inhibitors of nitric oxide synthase Abandoned AU2001282829A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0021706 2000-09-05
GB0021705 2000-09-05
GB0021705A GB0021705D0 (en) 2000-09-05 2000-09-05 Novel compounds
GB0021706A GB0021706D0 (en) 2000-09-05 2000-09-05 Novel compounds
SE0102156 2001-06-14
SE0102156A SE0102156D0 (sv) 2001-06-14 2001-06-14 Novel compounds
PCT/SE2001/001868 WO2002020511A1 (fr) 2000-09-05 2001-08-30 Derives d'amidine qui sont inhibiteurs de la synthase d'oxyde nitrique

Publications (1)

Publication Number Publication Date
AU2001282829A1 true AU2001282829A1 (en) 2002-03-22

Family

ID=27255875

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282829A Abandoned AU2001282829A1 (en) 2000-09-05 2001-08-30 Amidine derivatives which are inhibitors of nitric oxide synthase

Country Status (2)

Country Link
AU (1) AU2001282829A1 (fr)
WO (1) WO2002020511A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10162114A1 (de) * 2001-12-12 2003-06-26 Schering Ag Neue Amidin-Derivate und deren Verwendung in Arzneimitteln

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE231126T1 (de) * 1993-08-12 2003-02-15 Astrazeneca Ab Amidin-derivate mit stickstoffoxid-synthease- aktivität
FR2761066B1 (fr) * 1997-03-24 2000-11-24 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2764889B1 (fr) * 1997-06-20 2000-09-01 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
JPH10265450A (ja) * 1997-03-25 1998-10-06 Mitsui Chem Inc 一酸化窒素合成酵素阻害作用を有する新規なアミジン誘導体
SE9904676D0 (sv) * 1999-12-20 1999-12-20 Astra Ab Novel compounds
SE9904677D0 (sv) * 1999-12-20 1999-12-20 Astra Ab Novel compounds

Also Published As

Publication number Publication date
WO2002020511A1 (fr) 2002-03-14

Similar Documents

Publication Publication Date Title
AU4430599A (en) Inhibitors of nitric oxide synthase
AU2002222252A1 (en) Nitric oxide synthase inhibitor phosphate salt
GB0031179D0 (en) Nitric oxide synthase inhibitors
PL344368A1 (en) Nitric oxide synthase inhibitors
AU4774501A (en) Amidino compounds useful as nitric oxide synthase inhibitors
AU2001241927A1 (en) Inhibitors of p38-alpha kinase
MXPA03000772A (es) Derivados de acido hexahidro-7-1h-azepin-2-il-hexanoico como inhibidores de oxido nitrico sintasa inducible.
IL154842A0 (en) 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
AU2625201A (en) Glycogen synthase kinase-3 inhibitors
IL154841A (en) 2-amino-2-alkyl-5- heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors and intermediates
EE200000519A (et) Lämmastikoksiidi süntaasi inhibiitoritena toimivad halogeenitud amidinoaminohappederivaadid
AU2001282746A1 (en) Novel phenylheteroazetidines, useful as nitric oxide synthase inhibitors
IL132678A0 (en) Amidine derivatives as inhibitors of nitric oxide synthase
AU2417601A (en) Amidine derivatives which are inhibitors of nitric oxide synthase
GB9810299D0 (en) Use of nitric oxide synthase inhibitors
MXPA03002271A (es) Derivados de acido 2-amino-2-alquil-3-hexenoico y 2-amino-2-alquil-3-hexinoico utiles como inhibidores de oxido nitrico sintasa.
AU1539399A (en) Inhibitors of nitric oxide synthase
AU2002350575A1 (en) Selective neuronal nitric oxide synthase inhibitors
AU5119500A (en) New tricyclic amidine derivatives as inhibitors of nitric oxide synthase
AU2001282829A1 (en) Amidine derivatives which are inhibitors of nitric oxide synthase
AU2563601A (en) Amidine derivatives which are inhibitors of nitric oxide synthase
AU2002355706A1 (en) Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
AU4446500A (en) 5,7-bicyclic amidine derivatives useful as nitric oxide synthase inhibitors
AU2002355707A1 (en) Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
AU2002320003A1 (en) Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase