AU2001276911A1 - Azabicyclic derivatives and their therapeutic use - Google Patents
Azabicyclic derivatives and their therapeutic useInfo
- Publication number
- AU2001276911A1 AU2001276911A1 AU2001276911A AU7691101A AU2001276911A1 AU 2001276911 A1 AU2001276911 A1 AU 2001276911A1 AU 2001276911 A AU2001276911 A AU 2001276911A AU 7691101 A AU7691101 A AU 7691101A AU 2001276911 A1 AU2001276911 A1 AU 2001276911A1
- Authority
- AU
- Australia
- Prior art keywords
- azabicyclo
- pyridyl
- ethenyl
- jheptane
- ethynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/633,156 | 2000-08-04 | ||
US09/633,156 US6624167B1 (en) | 2000-08-04 | 2000-08-04 | Pharmaceutical compositions and methods for use |
PCT/US2001/022170 WO2002012245A2 (en) | 2000-08-04 | 2001-07-13 | Azabicyclic derivatives and their therapeutic use |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001276911A1 true AU2001276911A1 (en) | 2002-02-18 |
Family
ID=24538497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001276911A Abandoned AU2001276911A1 (en) | 2000-08-04 | 2001-07-13 | Azabicyclic derivatives and their therapeutic use |
Country Status (14)
Country | Link |
---|---|
US (2) | US6624167B1 (no) |
EP (1) | EP1305316A2 (no) |
JP (1) | JP2004536019A (no) |
CN (1) | CN1447811A (no) |
AU (1) | AU2001276911A1 (no) |
BR (1) | BR0113033A (no) |
CA (1) | CA2417967A1 (no) |
HU (1) | HUP0401225A3 (no) |
IL (1) | IL153897A0 (no) |
NO (1) | NO20030547L (no) |
NZ (1) | NZ523728A (no) |
PL (1) | PL363048A1 (no) |
WO (1) | WO2002012245A2 (no) |
ZA (1) | ZA200300571B (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005524712A (ja) * | 2002-05-07 | 2005-08-18 | ニューロサーチ、アクティーゼルスカブ | 新規アザシクロエチニル誘導体 |
AU2002313690A1 (en) * | 2002-07-19 | 2004-02-09 | Targacept, Inc. | Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors |
US7098331B2 (en) | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
PE20061162A1 (es) * | 2004-12-06 | 2006-10-14 | Smithkline Beecham Corp | Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos |
US20090239901A1 (en) * | 2008-03-19 | 2009-09-24 | Merouane Bencherif | Method and compositions for treatment of cerebral malaria |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
EP2509982A1 (en) | 2009-12-07 | 2012-10-17 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5817679A (en) | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
US6060473A (en) | 1993-04-01 | 2000-05-09 | Ucb S.A. - Dtb | 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands |
US5852041A (en) | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
JP3637973B2 (ja) | 1993-06-17 | 2005-04-13 | エーザイ株式会社 | アザビシクロヘプタン誘導体 |
US5510355A (en) | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
EP0842172A1 (en) | 1995-06-29 | 1998-05-20 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
EP0853621A1 (en) | 1995-09-22 | 1998-07-22 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
IL123583A (en) | 1995-10-13 | 2003-07-31 | Neurosearch As | 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them |
AU736798B2 (en) | 1997-05-30 | 2001-08-02 | Neurosearch A/S | 9-Azabicyclo(3.3.1)non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors |
US5952339A (en) | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
JP4676062B2 (ja) | 1999-01-29 | 2011-04-27 | アボット・ラボラトリーズ | ニコチン性アセチルコリン受容体リガンドとしてのジアザ2環式誘導体 |
FR2791678B1 (fr) | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
JP2003513054A (ja) | 1999-11-01 | 2003-04-08 | ターガセプト,インコーポレイテッド | アリールオレフィンアザ環式化合物及びアリールアセチレンアザ環式化合物、それらを含有する薬剤組成物、及び、ニコチンコリン作動性受容体の阻害薬としてのそれらの使用 |
GB0000257D0 (en) | 2000-01-07 | 2000-03-01 | Univ Bristol | 9-Azabicyclo[4.2.1]non-2-ene derivatives as ligands for nicotinic acetylcholine receptors |
-
2000
- 2000-08-04 US US09/633,156 patent/US6624167B1/en not_active Expired - Fee Related
-
2001
- 2001-07-13 WO PCT/US2001/022170 patent/WO2002012245A2/en active IP Right Grant
- 2001-07-13 CN CN01813738A patent/CN1447811A/zh active Pending
- 2001-07-13 NZ NZ523728A patent/NZ523728A/en unknown
- 2001-07-13 EP EP01954684A patent/EP1305316A2/en not_active Ceased
- 2001-07-13 HU HU0401225A patent/HUP0401225A3/hu unknown
- 2001-07-13 PL PL01363048A patent/PL363048A1/xx not_active Application Discontinuation
- 2001-07-13 JP JP2002518220A patent/JP2004536019A/ja not_active Withdrawn
- 2001-07-13 CA CA002417967A patent/CA2417967A1/en not_active Abandoned
- 2001-07-13 IL IL15389701A patent/IL153897A0/xx unknown
- 2001-07-13 BR BR0113033-1A patent/BR0113033A/pt not_active IP Right Cessation
- 2001-07-13 AU AU2001276911A patent/AU2001276911A1/en not_active Abandoned
-
2003
- 2003-01-21 ZA ZA200300571A patent/ZA200300571B/en unknown
- 2003-02-04 NO NO20030547A patent/NO20030547L/no unknown
- 2003-09-23 US US10/668,692 patent/US7022706B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PL363048A1 (en) | 2004-11-15 |
ZA200300571B (en) | 2004-04-21 |
WO2002012245B1 (en) | 2003-03-20 |
WO2002012245A3 (en) | 2002-06-13 |
NO20030547D0 (no) | 2003-02-04 |
CA2417967A1 (en) | 2002-02-14 |
US20040152723A1 (en) | 2004-08-05 |
HUP0401225A3 (en) | 2005-07-28 |
IL153897A0 (en) | 2003-07-31 |
JP2004536019A (ja) | 2004-12-02 |
HUP0401225A2 (hu) | 2004-12-28 |
NO20030547L (no) | 2003-02-04 |
BR0113033A (pt) | 2003-07-15 |
EP1305316A2 (en) | 2003-05-02 |
WO2002012245A2 (en) | 2002-02-14 |
NZ523728A (en) | 2004-09-24 |
US7022706B2 (en) | 2006-04-04 |
US6624167B1 (en) | 2003-09-23 |
CN1447811A (zh) | 2003-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |