HUP0401225A3 - Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their use - Google Patents
Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their useInfo
- Publication number
- HUP0401225A3 HUP0401225A3 HU0401225A HUP0401225A HUP0401225A3 HU P0401225 A3 HUP0401225 A3 HU P0401225A3 HU 0401225 A HU0401225 A HU 0401225A HU P0401225 A HUP0401225 A HU P0401225A HU P0401225 A3 HUP0401225 A3 HU P0401225A3
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- aromatic ring
- compositions containing
- azabicyclo derivatives
- bridged
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/633,156 US6624167B1 (en) | 2000-08-04 | 2000-08-04 | Pharmaceutical compositions and methods for use |
| PCT/US2001/022170 WO2002012245A2 (en) | 2000-08-04 | 2001-07-13 | Azabicyclic derivatives and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401225A2 HUP0401225A2 (hu) | 2004-12-28 |
| HUP0401225A3 true HUP0401225A3 (en) | 2005-07-28 |
Family
ID=24538497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401225A HUP0401225A3 (en) | 2000-08-04 | 2001-07-13 | Azabicyclo derivatives bridged with aromatic ring and pharmaceutical compositions containing them and process for their use |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6624167B1 (hu) |
| EP (1) | EP1305316A2 (hu) |
| JP (1) | JP2004536019A (hu) |
| CN (1) | CN1447811A (hu) |
| AU (1) | AU2001276911A1 (hu) |
| BR (1) | BR0113033A (hu) |
| CA (1) | CA2417967A1 (hu) |
| HU (1) | HUP0401225A3 (hu) |
| IL (1) | IL153897A0 (hu) |
| NO (1) | NO20030547D0 (hu) |
| NZ (1) | NZ523728A (hu) |
| PL (1) | PL363048A1 (hu) |
| WO (1) | WO2002012245A2 (hu) |
| ZA (1) | ZA200300571B (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003094830A2 (en) * | 2002-05-07 | 2003-11-20 | Neurosearch A/S | Novel azacyclic ethynyl derivatives |
| WO2004009599A1 (en) * | 2002-07-19 | 2004-01-29 | Targacept, Inc. | Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors |
| US7098331B2 (en) * | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
| US20070021612A1 (en) * | 2004-11-04 | 2007-01-25 | University Of Notre Dame Du Lac | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof |
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| PE20061162A1 (es) * | 2004-12-06 | 2006-10-14 | Smithkline Beecham Corp | Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos |
| US20090239901A1 (en) * | 2008-03-19 | 2009-09-24 | Merouane Bencherif | Method and compositions for treatment of cerebral malaria |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| PE20121556A1 (es) | 2009-12-07 | 2012-12-05 | Targacept Inc | 3,6-diazabiciclo[3.1.1]heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817679A (en) | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
| US6060473A (en) | 1993-04-01 | 2000-05-09 | Ucb S.A. - Dtb | 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands |
| US5852041A (en) | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
| JP3637973B2 (ja) | 1993-06-17 | 2005-04-13 | エーザイ株式会社 | アザビシクロヘプタン誘導体 |
| US5510355A (en) | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
| US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| US6022868A (en) | 1995-06-29 | 2000-02-08 | Novo Nordisk Als | Substituted azacyclic or azabicyclic compounds |
| EP0853621A1 (en) | 1995-09-22 | 1998-07-22 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
| KR100274829B1 (ko) | 1995-10-13 | 2000-12-15 | 페더 벨링 | 8-아자바이사이클로[3,2,1]-옥트-2-엔 유도체의 제조방법 및 용도 |
| JP2002502383A (ja) | 1997-05-30 | 2002-01-22 | ニューロサーアチ・アクティーゼルスカブ | ニコチンＡＣｈレセプターに於けるコリン作動性リガンドとしての９−アザビシクロ（３．３．１）ノン−２−エン及びノナン誘導体 |
| US5952339A (en) | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| CA2361525C (en) | 1999-01-29 | 2009-12-08 | Abbott Laboratories | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands |
| FR2791678B1 (fr) | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de 1,4-diazabicyclo [3.2.2] nonane-4-carboxylates et -carboxamides, leur preparation et leur application en therapeutique |
| WO2001032264A1 (en) | 1999-11-01 | 2001-05-10 | Targacept, Inc. | Aryl olefinic azacyclic, and aryl acetylenic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| GB0000257D0 (en) | 2000-01-07 | 2000-03-01 | Univ Bristol | 9-Azabicyclo[4.2.1]non-2-ene derivatives as ligands for nicotinic acetylcholine receptors |
-
2000
- 2000-08-04 US US09/633,156 patent/US6624167B1/en not_active Expired - Fee Related
-
2001
- 2001-07-13 EP EP01954684A patent/EP1305316A2/en not_active Ceased
- 2001-07-13 HU HU0401225A patent/HUP0401225A3/hu unknown
- 2001-07-13 CN CN01813738A patent/CN1447811A/zh active Pending
- 2001-07-13 IL IL15389701A patent/IL153897A0/xx unknown
- 2001-07-13 NZ NZ523728A patent/NZ523728A/en unknown
- 2001-07-13 JP JP2002518220A patent/JP2004536019A/ja not_active Withdrawn
- 2001-07-13 BR BR0113033-1A patent/BR0113033A/pt not_active IP Right Cessation
- 2001-07-13 CA CA002417967A patent/CA2417967A1/en not_active Abandoned
- 2001-07-13 PL PL01363048A patent/PL363048A1/xx not_active Application Discontinuation
- 2001-07-13 WO PCT/US2001/022170 patent/WO2002012245A2/en active IP Right Grant
- 2001-07-13 AU AU2001276911A patent/AU2001276911A1/en not_active Abandoned
-
2003
- 2003-01-21 ZA ZA200300571A patent/ZA200300571B/en unknown
- 2003-02-04 NO NO20030547A patent/NO20030547D0/no unknown
- 2003-09-23 US US10/668,692 patent/US7022706B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001276911A1 (en) | 2002-02-18 |
| BR0113033A (pt) | 2003-07-15 |
| CN1447811A (zh) | 2003-10-08 |
| PL363048A1 (en) | 2004-11-15 |
| NZ523728A (en) | 2004-09-24 |
| US20040152723A1 (en) | 2004-08-05 |
| WO2002012245A3 (en) | 2002-06-13 |
| IL153897A0 (en) | 2003-07-31 |
| WO2002012245A2 (en) | 2002-02-14 |
| WO2002012245B1 (en) | 2003-03-20 |
| HUP0401225A2 (hu) | 2004-12-28 |
| CA2417967A1 (en) | 2002-02-14 |
| NO20030547L (no) | 2003-02-04 |
| JP2004536019A (ja) | 2004-12-02 |
| ZA200300571B (en) | 2004-04-21 |
| US7022706B2 (en) | 2006-04-04 |
| US6624167B1 (en) | 2003-09-23 |
| EP1305316A2 (en) | 2003-05-02 |
| NO20030547D0 (no) | 2003-02-04 |
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