AU2001267686A1 - Topical pharmaceutical formulations and methods of treatment - Google Patents
Topical pharmaceutical formulations and methods of treatmentInfo
- Publication number
- AU2001267686A1 AU2001267686A1 AU2001267686A AU6768601A AU2001267686A1 AU 2001267686 A1 AU2001267686 A1 AU 2001267686A1 AU 2001267686 A AU2001267686 A AU 2001267686A AU 6768601 A AU6768601 A AU 6768601A AU 2001267686 A1 AU2001267686 A1 AU 2001267686A1
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutical formulation
- therapeutic agent
- skin
- formulation
- carrier medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000000034 method Methods 0.000 title claims description 110
- 238000011282 treatment Methods 0.000 title claims description 29
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- 239000000203 mixture Substances 0.000 claims abstract description 222
- 239000003814 drug Substances 0.000 claims abstract description 182
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 172
- 238000009472 formulation Methods 0.000 claims abstract description 133
- 230000000694 effects Effects 0.000 claims abstract description 44
- 239000007787 solid Substances 0.000 claims abstract description 39
- 239000003937 drug carrier Substances 0.000 claims abstract description 22
- 238000011200 topical administration Methods 0.000 claims abstract description 19
- 241000124008 Mammalia Species 0.000 claims abstract description 15
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- 239000004705 High-molecular-weight polyethylene Substances 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000021355 Stearic acid Nutrition 0.000 claims description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
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- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 3
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- 239000004342 Benzoyl peroxide Substances 0.000 claims description 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 3
- 201000004624 Dermatitis Diseases 0.000 claims description 3
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 3
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- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 3
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- 206010000496 acne Diseases 0.000 claims description 3
- DJHCCTTVDRAMEH-DUUJBDRPSA-N alclometasone dipropionate Chemical compound C([C@H]1Cl)C2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O DJHCCTTVDRAMEH-DUUJBDRPSA-N 0.000 claims description 3
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- NUZWLKWWNNJHPT-UHFFFAOYSA-N anthralin Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 claims description 3
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 3
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- 229960002537 betamethasone Drugs 0.000 claims description 3
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 3
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- 229960003957 dexamethasone Drugs 0.000 claims description 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 3
- 229960004154 diflorasone Drugs 0.000 claims description 3
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Landscapes
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| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
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| US20070065463A1 (en) | 2003-06-20 | 2007-03-22 | Ronald Aung-Din | Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions |
| US7718674B2 (en) * | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| DE102004059613A1 (de) * | 2004-12-10 | 2006-06-14 | Liedtke, Rainer K., Dr. | Zusammensetzung und Methode einer topischen Therapie von Neurodermitis |
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| GB0612556D0 (en) * | 2006-06-23 | 2006-08-02 | Univ Aston | Topical pharmaceutical formulations |
| US20090221703A1 (en) * | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
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2001
- 2001-06-26 EP EP01945471A patent/EP1296652B1/en not_active Expired - Lifetime
- 2001-06-26 KR KR1020027017591A patent/KR20030041871A/ko not_active Withdrawn
- 2001-06-26 BR BR0112356-4A patent/BR0112356A/pt not_active Application Discontinuation
- 2001-06-26 HU HU0301121A patent/HUP0301121A3/hu unknown
- 2001-06-26 EP EP07122565A patent/EP2027851A1/en not_active Withdrawn
- 2001-06-26 CA CA2413699A patent/CA2413699C/en not_active Expired - Fee Related
- 2001-06-26 DK DK01945471T patent/DK1296652T3/da active
- 2001-06-26 IL IL15366501A patent/IL153665A0/xx not_active IP Right Cessation
- 2001-06-26 AT AT01945471T patent/ATE429904T1/de active
- 2001-06-26 MX MXPA02012666A patent/MXPA02012666A/es active IP Right Grant
- 2001-06-26 US US10/312,475 patent/US7754240B2/en not_active Expired - Fee Related
- 2001-06-26 AU AU2001267686A patent/AU2001267686A1/en not_active Abandoned
- 2001-06-26 DE DE60138547T patent/DE60138547D1/de not_active Expired - Lifetime
- 2001-06-26 ES ES01945471T patent/ES2325980T3/es not_active Expired - Lifetime
- 2001-06-26 WO PCT/GB2001/002823 patent/WO2002000203A1/en not_active Ceased
- 2001-06-26 JP JP2002504985A patent/JP2004501185A/ja not_active Ceased
- 2001-06-26 CN CN01811778A patent/CN1438878A/zh active Pending
- 2001-06-26 PL PL360868A patent/PL211890B1/pl not_active IP Right Cessation
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2002
- 2002-12-18 ZA ZA200210224A patent/ZA200210224B/en unknown
- 2002-12-20 NO NO20026171A patent/NO333292B1/no not_active IP Right Cessation
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2006
- 2006-06-09 AU AU2006202479A patent/AU2006202479C1/en not_active Ceased
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2008
- 2008-03-19 US US12/077,331 patent/US20080166413A1/en not_active Abandoned
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2010
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