AU2001264515A1 - Melphalan derivatives and their use as cancer chemotherapeutic drugs - Google Patents

Melphalan derivatives and their use as cancer chemotherapeutic drugs

Info

Publication number
AU2001264515A1
AU2001264515A1 AU2001264515A AU6451501A AU2001264515A1 AU 2001264515 A1 AU2001264515 A1 AU 2001264515A1 AU 2001264515 A AU2001264515 A AU 2001264515A AU 6451501 A AU6451501 A AU 6451501A AU 2001264515 A1 AU2001264515 A1 AU 2001264515A1
Authority
AU
Australia
Prior art keywords
chemotherapeutic drugs
cancer chemotherapeutic
melphalan
melphalan derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264515A
Other languages
English (en)
Inventor
Hans Ehrsson
Joakim Gullbo
Rolf Larsson
Rolf Lewensohn
Kristina Luthman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncopeptides AB
Original Assignee
Oncopeptides AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncopeptides AB filed Critical Oncopeptides AB
Publication of AU2001264515A1 publication Critical patent/AU2001264515A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2001264515A 2000-06-13 2001-06-11 Melphalan derivatives and their use as cancer chemotherapeutic drugs Abandoned AU2001264515A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21122700P 2000-06-13 2000-06-13
SE0002202 2000-06-13
US60211227 2000-06-13
SE0002202A SE0002202D0 (sv) 2000-06-13 2000-06-13 New peptides
PCT/SE2001/001318 WO2001096367A1 (en) 2000-06-13 2001-06-11 Melphalan derivatives and their use as cancer chemotherapeutic drugs

Publications (1)

Publication Number Publication Date
AU2001264515A1 true AU2001264515A1 (en) 2001-12-24

Family

ID=20280067

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001264515A Abandoned AU2001264515A1 (en) 2000-06-13 2001-06-11 Melphalan derivatives and their use as cancer chemotherapeutic drugs

Country Status (10)

Country Link
EP (1) EP1290011B1 (da)
JP (1) JP4798930B2 (da)
AT (1) ATE458746T1 (da)
AU (1) AU2001264515A1 (da)
CA (1) CA2408501C (da)
DK (1) DK1290011T3 (da)
ES (1) ES2341702T3 (da)
PT (1) PT1290011E (da)
SE (1) SE0002202D0 (da)
WO (1) WO2001096367A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1374907A3 (en) * 2002-06-24 2004-01-07 Ghanem Elias c/o Institut Jules Bordet Ghanem Drug transport and delivery system
DE10239832A1 (de) * 2002-08-29 2004-03-18 Lipal Biochemicals AG c/o University of Zurich Sarcolysyl-Derivate und Verfahren zu deren Herstellung
WO2011011865A1 (en) * 2009-07-29 2011-02-03 3R Valo, S.E.C. Anticancer agents based on amino acid derivatives
WO2011078782A1 (en) * 2009-12-22 2011-06-30 Oncopeptides Ab A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer
EP2701720B1 (en) 2011-04-28 2017-07-12 Oncopeptides AB Lyophilized preparation of cytotoxic dipeptides
LT3228319T (lt) * 2011-04-28 2020-09-25 Oncopeptides Ab Liofilizuotas citotoksinių dipeptidų preparatas
LT2928463T (lt) * 2012-10-26 2020-02-10 Oncopeptides Ab Liofilizuoti melfalano flufenamido preparatai
JP6284945B2 (ja) 2012-10-26 2018-02-28 オンコペプティデス エービーＯｎｃｏｐｅｐｔｉｄｅｓ ＡＢ メルファランフルフェナミドの凍結乾燥製剤
GB201507903D0 (en) 2015-05-08 2015-06-24 Oncopeptides Ab Process for preparation of nitrogen mustard derivatives
GB201521217D0 (en) * 2015-12-01 2016-01-13 Oncopeptides Ab Dosage regimens
CN108864251B (zh) * 2018-06-30 2022-06-14 大连理工大学 一类氨肽酶n激活的药物前体化合物及其制备方法和应用
ES2942468T3 (es) * 2018-10-18 2023-06-01 Oncopeptides Ab Compuestos que contienen deuterio
EP3946309A1 (en) 2019-04-03 2022-02-09 Oncopeptides AB Treatment of al amyloidosis with melflufen
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
WO2021053185A1 (en) 2019-09-20 2021-03-25 Oncopeptides Ab Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
WO2022167087A1 (en) * 2021-02-05 2022-08-11 Oncopeptides Ab Peptidase enhanced cytotoxic dipeptides
EP4083052A1 (en) 2021-04-29 2022-11-02 BKmdcl AB Peptide conjugates of melphalan for the treatment of cancer
WO2022253894A1 (en) 2021-06-01 2022-12-08 Synthon B.V. Process for making melflufen or a salt thereof
EP4366721A1 (en) 2021-07-08 2024-05-15 Oncopeptides Innovation AB Melflufen for use in the treatment of multiple myeloma
GB202109896D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109895D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109894D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202204171D0 (en) 2022-03-24 2022-05-11 Oncopeptides Ab Novel formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB750155A (en) 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines

Also Published As

Publication number Publication date
WO2001096367A1 (en) 2001-12-20
DK1290011T3 (da) 2010-06-07
EP1290011A1 (en) 2003-03-12
CA2408501C (en) 2011-01-18
SE0002202D0 (sv) 2000-06-13
JP4798930B2 (ja) 2011-10-19
JP2004503564A (ja) 2004-02-05
ATE458746T1 (de) 2010-03-15
ES2341702T3 (es) 2010-06-25
CA2408501A1 (en) 2001-12-20
PT1290011E (pt) 2010-05-11
EP1290011B1 (en) 2010-02-24

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