AU2001263481A1 - Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks - Google Patents

Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks

Info

Publication number
AU2001263481A1
AU2001263481A1 AU2001263481A AU6348101A AU2001263481A1 AU 2001263481 A1 AU2001263481 A1 AU 2001263481A1 AU 2001263481 A AU2001263481 A AU 2001263481A AU 6348101 A AU6348101 A AU 6348101A AU 2001263481 A1 AU2001263481 A1 AU 2001263481A1
Authority
AU
Australia
Prior art keywords
patterning
dimensionally arrayed
channel networks
surfaces utilizing
utilizing microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001263481A
Other languages
English (en)
Inventor
Janelle R. Anderson
Daniel T. Chiu
Insung S. Choi
Sui Huang
Donald E Ingber
Noo-Li Jeon
Ravi Kane
George M. Whitesides
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Childrens Medical Center Corp
Original Assignee
Harvard College
Childrens Medical Center Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Childrens Medical Center Corp filed Critical Harvard College
Publication of AU2001263481A1 publication Critical patent/AU2001263481A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0258—Drop counters; Drop formers using stamps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/10—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. casting around inserts or for coating articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/009—Manufacturing the stamps or the moulds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C31/00—Handling, e.g. feeding of the material to be shaped, storage of plastics material before moulding; Automation, i.e. automated handling lines in plastics processing plants, e.g. using manipulators or robots
    • B29C31/04—Feeding of the material to be moulded, e.g. into a mould cavity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/42—Moulds or cores; Details thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
    • B29C33/424—Moulding surfaces provided with means for marking or patterning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Composite Materials (AREA)
  • Genetics & Genomics (AREA)
  • Computer Hardware Design (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
AU2001263481A 2000-05-25 2001-05-25 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks Abandoned AU2001263481A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/578,562 2000-05-25
US09/578,562 US6686184B1 (en) 2000-05-25 2000-05-25 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
PCT/US2001/017246 WO2001089788A2 (fr) 2000-05-25 2001-05-25 Formation de motifs sur des surfaces, au moyen de tampons microfluidiques comprenant des reseaux de canaux disposes en trois dimensions

Publications (1)

Publication Number Publication Date
AU2001263481A1 true AU2001263481A1 (en) 2001-12-03

Family

ID=24313401

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001263481A Abandoned AU2001263481A1 (en) 2000-05-25 2001-05-25 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks

Country Status (4)

Country Link
US (2) US6686184B1 (fr)
EP (1) EP1283748A2 (fr)
AU (1) AU2001263481A1 (fr)
WO (1) WO2001089788A2 (fr)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
US7282240B1 (en) * 1998-04-21 2007-10-16 President And Fellows Of Harvard College Elastomeric mask and use in fabrication of devices
US7258003B2 (en) * 1998-12-07 2007-08-21 Honeywell International Inc. Flow sensor with self-aligned flow channel
JP2003527615A (ja) * 2000-03-17 2003-09-16 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 細胞パターニング技術
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US7323143B2 (en) * 2000-05-25 2008-01-29 President And Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US20020182633A1 (en) * 2000-07-11 2002-12-05 Chen Christopher S. Methods of patterning protein and cell adhesivity
WO2002022787A2 (fr) 2000-09-18 2002-03-21 President And Fellows Of Harvard College Traitement differentiel de parties choisies d'une seule cellule comprenant differents composants fluidiques
AU1342302A (en) * 2000-09-18 2002-03-26 Harvard College Method and apparatus for gradient generation
US7371563B2 (en) * 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US6951632B2 (en) * 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
US7433744B2 (en) * 2001-06-21 2008-10-07 Robert A Bell Method and apparatus for spatially coordinating, storing and manipulating computer aided design drawings
US20030006527A1 (en) * 2001-06-22 2003-01-09 Rabolt John F. Method of fabricating micron-and submicron-scale elastomeric templates for surface patterning
WO2003015890A1 (fr) * 2001-08-20 2003-02-27 President And Fellows Of Harvard College Jeux ordonnes d'echantillons fluides et procede d'utilisation
US7090003B2 (en) * 2001-10-19 2006-08-15 Wisconsin Alumni Research Foundation Method and apparatus for temperature control of a microfluidic device
SE526185C2 (sv) * 2001-11-07 2005-07-19 Prolight Diagnostics Ab Metod och anordning för immunanalys
US7244393B2 (en) * 2001-12-21 2007-07-17 Kimberly-Clark Worldwide, Inc. Diagnostic device and system
DE10201640A1 (de) * 2002-01-17 2003-08-07 Fraunhofer Ges Forschung Verfahren zur Herstellung einer Folie mit Oberflächenstrukturen im Mikro- und Nanometerbereich sowie eine diesbezügliche Folie
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
GB0216077D0 (en) * 2002-07-11 2002-08-21 Univ Cranfield Reconfigurable microfluidic device
US20040156988A1 (en) * 2002-08-26 2004-08-12 Mehenti Neville Z. Selective and alignment-free molecular patterning of surfaces
US6805809B2 (en) * 2002-08-28 2004-10-19 Board Of Trustees Of University Of Illinois Decal transfer microfabrication
WO2004067191A2 (fr) 2003-01-29 2004-08-12 President And Fellows Of Harward College Alteration des affinites de surface
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP2266687A3 (fr) 2003-04-10 2011-06-29 The President and Fellows of Harvard College Formation et contrôle d'espèces fluides
US20050191419A1 (en) * 2003-04-11 2005-09-01 Helt James M. Fabrication of nanostructures
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20040219711A1 (en) * 2003-04-30 2004-11-04 Bi-Chu Wu Method for manufacturing a polymer chip and an integrated mold for the same
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
EP2662135A3 (fr) 2003-08-27 2013-12-25 President and Fellows of Harvard College Méthode de mélange de gouttelettes dans un microcanal
CA2540035C (fr) * 2003-09-23 2012-11-20 University Of North Carolina At Chapel Hill Perfluoropolyethers photopolymerisables destines a etre utilises comme nouveaux materiaux dans des dispositifs microfluidiques
US20050067286A1 (en) * 2003-09-26 2005-03-31 The University Of Cincinnati Microfabricated structures and processes for manufacturing same
US7114448B2 (en) * 2003-11-06 2006-10-03 Palo Alto Research Center, Incorporated Method for large-area patterning dissolved polymers by making use of an active stamp
EP1542074A1 (fr) * 2003-12-11 2005-06-15 Heptagon OY Fabrication d'un outil de replication
KR101376715B1 (ko) 2003-12-19 2014-03-27 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 소프트 또는 임프린트 리소그래피를 이용하여 분리된 마이크로- 및 나노- 구조를 제작하는 방법
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
US20070275193A1 (en) * 2004-02-13 2007-11-29 Desimone Joseph M Functional Materials and Novel Methods for the Fabrication of Microfluidic Devices
US7504038B2 (en) * 2004-02-26 2009-03-17 Hitachi Global Storage Technologies Netherlands B.V. System, method, and apparatus for mechanically releasable slider processing including lapping, air bearing patterning, and debonding
US8058056B2 (en) * 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US20060014271A1 (en) * 2004-07-16 2006-01-19 Yujun Song Fabrication of a completely polymeric microfluidic reactor for chemical synthesis
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7662545B2 (en) * 2004-10-14 2010-02-16 The Board Of Trustees Of The University Of Illinois Decal transfer lithography
US20060138083A1 (en) * 2004-10-26 2006-06-29 Declan Ryan Patterning and alteration of molecules
US20090027603A1 (en) * 2005-02-03 2009-01-29 Samulski Edward T Low Surface Energy Polymeric Material for Use in Liquid Crystal Displays
AU2006220816A1 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US8551403B2 (en) * 2005-03-10 2013-10-08 Raustech Pty Ltd. Disc substrates for combinatorial chemistry
JP2008546542A (ja) * 2005-05-18 2008-12-25 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ マイクロ流体ネットワークにおける伝導通路、マイクロ回路、マイクロ構造の製造
US20070032846A1 (en) * 2005-08-05 2007-02-08 Bran Ferren Holographic tattoo
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007133235A2 (fr) * 2005-08-08 2007-11-22 Liquidia Technologies, Inc. Métrologie de micro et de nanostructures
EP1922364A4 (fr) 2005-08-09 2010-04-21 Univ North Carolina Procedes et materiaux permettant de fabriquer des dispositifs microfluidiques
KR100758699B1 (ko) * 2005-08-29 2007-09-14 재단법인서울대학교산학협력재단 고종횡비 나노구조물 형성방법 및 이를 이용한 미세패턴형성방법
JP2009508596A (ja) 2005-09-19 2009-03-05 ヒストジェニックス コーポレイション 細胞支持基材及びその調製方法
EP2363205A3 (fr) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Dispositifs Microfluidiques Et Leurs Procédés D'utilisation Dans La Formation Et Le Contrôle De Nanoréacteurs
CN101410323B (zh) * 2006-01-24 2012-11-07 迈克罗拉布诊断有限公司 压印方法和器件
JP5016611B2 (ja) * 2006-01-24 2012-09-05 マイクロラボ ピーティーワイ エルティーディー スタンピング方法
AU2007210152A1 (en) 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
EP1820571B1 (fr) * 2006-02-09 2009-05-27 Roche Diagnostics GmbH Structures 3D à base de substrats 2D
US8293524B2 (en) * 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US8101114B2 (en) * 2006-05-01 2012-01-24 Georgia Tech Research Corporation Particle based molding
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007133710A2 (fr) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation
US8501117B1 (en) 2006-06-05 2013-08-06 Carnegie Mellon University Apparatuses, systems, and methods utilizing capillary action
WO2008011051A1 (fr) * 2006-07-17 2008-01-24 Liquidia Technologies, Inc. Procédés, systèmes et matériaux de fabrication de nanoparticules
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
US20110244567A1 (en) 2006-08-31 2011-10-06 Snu R&Db Foundation Device and Method of 3-Dimensionally Generating IN VITRO Blood Vessels
US7947491B2 (en) * 2006-08-31 2011-05-24 The Regents Of The University Of California Microfluidic gradient devices
US8617143B2 (en) * 2006-12-07 2013-12-31 The Regents Of The University Of California Therapeutic agent delivery systems and devices
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8435551B2 (en) * 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US20100151031A1 (en) * 2007-03-23 2010-06-17 Desimone Joseph M Discrete size and shape specific organic nanoparticles designed to elicit an immune response
EP2136786B8 (fr) 2007-03-28 2012-11-14 President and Fellows of Harvard College Dispositif de formation de gouttelettes
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
WO2009058015A1 (fr) * 2007-11-02 2009-05-07 Universiteit Twente Procédé de criblage haut débit et appareil pour analyser des interactions entre des surfaces avec une topographie différente et l'environnement
WO2009086535A2 (fr) * 2007-12-27 2009-07-09 The Trustees Of Columbia University In The City Of New York Systèmes et procédés de formation de matériaux de matrice extracellulaire comportant un motif
US20090243140A1 (en) * 2008-02-01 2009-10-01 Barry Levenson Art infused films and methods for making the same
WO2009111069A1 (fr) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Produits de recombinaison spongieux, particules de cartilage et associations de produits de recombinaison spongieux et de particules de cartilage
US20090253981A1 (en) * 2008-04-03 2009-10-08 Hamilton Brian H Skin Marking Tool for Radiological Imaging Material
WO2009129430A2 (fr) * 2008-04-18 2009-10-22 University Of Massachusetts Lowell Procédés de formation d'un outillage hybride métal-polymère pour former des pièces comportant des microcaractéristiques
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
CN101318119B (zh) * 2008-05-30 2010-12-01 北京化工大学 适于光化学反应的聚合物基微流体反应器及制备方法
WO2010009365A1 (fr) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Bibliothèque de gouttelettes
WO2010062441A1 (fr) * 2008-10-31 2010-06-03 Massachusetts Institute Of Technology Procédé utilisant une résine liquide durcissant rapidement pour la fabrication de pièces à micro- ou nanomotifs
WO2010083051A2 (fr) * 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Mélanges de tissus cartilagineux particulaires éventuellement associés à une structure spongieuse
EP3415235A1 (fr) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation de gouttelettes microfluidiques
US9182411B2 (en) * 2009-07-14 2015-11-10 Colen Innovations, L.L.C. Methods and apparatus for the detection and differentiation of non-sialated proteins from sialated proteins in a fluid sample
BR112012004719A2 (pt) 2009-09-02 2016-04-05 Harvard College emulsões múltiplas criadas por uso de jateamento e outras técnicas
EP2486409A1 (fr) 2009-10-09 2012-08-15 Universite De Strasbourg Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations
WO2011079176A2 (fr) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Systèmes microfluidiques et procédés pour réduire l'échange de molécules entre des gouttelettes
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (fr) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Analyse numérique d'analytes
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
WO2011115580A1 (fr) * 2010-03-17 2011-09-22 Agency For Science, Technology And Research Procédé de fabrication d'un ensemble
CN102870193B (zh) 2010-04-02 2016-01-13 罗地亚管理公司 选择性纳米颗粒组装系统和方法
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
DE102010061910B4 (de) * 2010-11-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidvorrichtung und Verfahren zum Herstellen derselben
WO2012109600A2 (fr) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Procédés de formation de gouttelettes mélangées
DE112011106142B3 (de) * 2011-02-15 2020-12-17 National Research Council Of Canada Durchbrochene thermoplastische Elastomer-Membran, ihre Verwendung und Verfahren zu ihrer Herstellung
WO2012109724A1 (fr) 2011-02-15 2012-08-23 National Research Council Of Canada Dispositifs microfluidiques 3d à base de membranes élastomères thermoplastiques à ouverture traversante
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
JP2012190986A (ja) * 2011-03-10 2012-10-04 Fujifilm Corp ナノインプリント用のモールド
CA2830103C (fr) 2011-03-15 2020-03-24 National Research Council Of Canada Systeme microfluidique ayant des structures monolithiques nanoplasmoniques
BR112013029729A2 (pt) 2011-05-23 2017-01-24 Basf Se controle de emulsões, incluindo emulsões múltiplas
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
US20140220350A1 (en) 2011-07-06 2014-08-07 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US8850895B2 (en) * 2011-09-03 2014-10-07 John Yan Unpowered, wireless pressure sensor for point-of-care glaucoma diagnosis
EP3309262B1 (fr) 2012-02-24 2019-09-25 Bio-Rad Laboratories, Inc. Marquage et préparation d'échantillon pour le séquençage
US9770721B2 (en) * 2012-03-27 2017-09-26 The Regents Of The University Of California Continuous whole-chip 3-dimensional DEP cell sorter and related fabrication method
WO2014011775A1 (fr) * 2012-07-10 2014-01-16 The Trustees Of The University Of Pennsylvania Biomatériaux destinés à améliorer l'intégration de l'implant au sein de l'hôte
GB2584364A (en) 2013-03-15 2020-12-02 Abvitro Llc Single cell bar-coding for antibody discovery
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015077717A1 (fr) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions et méthodes pour diagnostiquer, évaluer et traiter un cancer au moyen d'un état de méthylation d'adn
US9155201B2 (en) * 2013-12-03 2015-10-06 Eastman Kodak Company Preparation of articles with conductive micro-wire pattern
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
NZ721908A (en) 2013-12-20 2022-12-23 Massachusetts Gen Hospital Combination therapy with neoantigen vaccine
CN104745445B (zh) * 2013-12-30 2018-04-27 中国科学院深圳先进技术研究院 一种构建细胞网络的三维微流控芯片及其制备方法
EP3090063B1 (fr) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Procédé de détection de rétrovirus latent
US9365019B2 (en) 2014-06-23 2016-06-14 Xerox Corporation Apparatus for forming hydrophobic structures in porous substrates
US9480980B2 (en) 2014-06-23 2016-11-01 Xerox Corporation Apparatus for producing paper-based chemical assay devices
US9415610B2 (en) 2014-06-23 2016-08-16 Xerox Corporation System and method for forming hydrophobic structures in a porous substrate
US9686540B2 (en) 2014-06-23 2017-06-20 Xerox Corporation Robust colorimetric processing method for paper based sensors
US9266105B2 (en) 2014-06-23 2016-02-23 Xerox Corporation System and method for forming bonded substrates
US9346048B2 (en) * 2014-06-23 2016-05-24 Xerox Corporation Paper-based chemical assay devices with improved fluidic structures
US10895544B2 (en) * 2014-08-21 2021-01-19 Schlumberger Technology Corporation Measurement of liquid parameters using a microfluidic device
EP3536786B1 (fr) 2014-09-15 2021-06-30 AbVitro LLC Séquençage à haut débit de banque de nucléotides
WO2016077750A1 (fr) 2014-11-14 2016-05-19 Athena Diagnostics, Inc. Procédés permettant de détecter un génotype de porteur sain
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10975442B2 (en) 2014-12-19 2021-04-13 Massachusetts Institute Of Technology Molecular biomarkers for cancer immunotherapy
EP3757211A1 (fr) 2014-12-19 2020-12-30 The Broad Institute, Inc. Procédés pour le profilage de répertoire de récepteurs de lymphocytes t
WO2016161081A1 (fr) 2015-04-03 2016-10-06 Fluxion Biosciences, Inc. Caractérisation moléculaire de cellules individuelles et de populations de cellules pour diagnostics non invasifs
US9403358B1 (en) 2015-04-17 2016-08-02 Xerox Corporation System and method for forming hydrophobic structures in a hydrophilic print medium
US10835585B2 (en) 2015-05-20 2020-11-17 The Broad Institute, Inc. Shared neoantigens
WO2016205728A1 (fr) 2015-06-17 2016-12-22 Massachusetts Institute Of Technology Enregistrement d'événements cellulaires médié par crispr
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
AU2016326737B2 (en) 2015-09-24 2023-01-12 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
CA2999886A1 (fr) 2015-09-24 2017-03-30 Abvitro Llc Acp par exclusion activee a produit d'amplification unique
WO2017053902A1 (fr) 2015-09-25 2017-03-30 Abvitro Llc Procédé à haut débit pour l'identification ciblée de séquences de récepteurs de lymphocytes t naturellement appariées
US11338065B2 (en) 2015-10-08 2022-05-24 Massachusetts Institute Of Technology In situ expansion of engineered devices for regeneration
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
WO2017075294A1 (fr) 2015-10-28 2017-05-04 The Board Institute Inc. Dosages utilisés pour le profilage de perturbation massivement combinatoire et la reconstruction de circuit cellulaire
US9987508B2 (en) * 2016-08-31 2018-06-05 Emerson Process Management Regulator Technologies Tulsa, Llc Hybrid composite flame cell
JP6929354B2 (ja) 2016-09-24 2021-09-01 アブビトロ， エルエルシー 親和性−オリゴヌクレオチドコンジュゲートおよびその使用
WO2018140391A1 (fr) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions et procédés de détection d'un variant mutant d'un polynucléotide
WO2018195019A1 (fr) 2017-04-18 2018-10-25 The Broad Institute Inc. Composition permettant de détecter une sécrétion et procédé d'utilisation
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
US20200354784A1 (en) 2017-05-26 2020-11-12 Abvitro Llc High-throughput polynucleotide library sequencing and transcriptome analysis
EP3679370A1 (fr) 2017-09-07 2020-07-15 Juno Therapeutics, Inc. Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire
WO2019079301A2 (fr) 2017-10-18 2019-04-25 Group K Diagnostics, Inc. Dispositif microfluidique monocouche et ses procédés de fabrication et d'utilisation
US11332736B2 (en) 2017-12-07 2022-05-17 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
US11841371B2 (en) 2018-03-13 2023-12-12 The Broad Institute, Inc. Proteomics and spatial patterning using antenna networks
US20220411783A1 (en) 2018-10-12 2022-12-29 The Broad Institute, Inc. Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
USD879999S1 (en) 2018-11-02 2020-03-31 Group K Diagnostics, Inc. Microfluidic device
JP2024516637A (ja) 2021-04-26 2024-04-16 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド ポリヌクレオチド配列の変化を特徴決定するための組成物および方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
EP0894043B1 (fr) 1996-03-15 2001-10-31 President And Fellows Of Harvard College Procede de formation d'articles et de surfaces a motifs par micromoulage capillaire
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6719868B1 (en) 1998-03-23 2004-04-13 President And Fellows Of Harvard College Methods for fabricating microfluidic structures
JP2002512124A (ja) 1998-04-21 2002-04-23 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ エラストマ・マスク、およびピクセル化されたエレクトロルミネセンス・ディスプレイを含む装置の製造における使用
US6334301B1 (en) 1999-02-25 2002-01-01 Vacco Industries, Inc. Assembly of etched sheets forming a fluidic module
WO2001003208A1 (fr) 1999-07-02 2001-01-11 President And Fellows Of Harvard College Dispositifs s nanoscopiques a base de fils, ensembles ainsi formes et procedes de fabrication y relatifs
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
EP1350029B1 (fr) 2001-01-08 2014-09-10 President and Fellows of Harvard College Vannes et pompes destinees a des systemes microfluidiques et procede de realisation de systemes microfluidiques

Also Published As

Publication number Publication date
WO2001089788A9 (fr) 2002-12-12
WO2001089788A2 (fr) 2001-11-29
US6686184B1 (en) 2004-02-03
US7267938B2 (en) 2007-09-11
US20040121066A1 (en) 2004-06-24
EP1283748A2 (fr) 2003-02-19
WO2001089788A3 (fr) 2002-06-06

Similar Documents

Publication Publication Date Title
AU2001263481A1 (en) Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
AU6496001A (en) Microfluidic systems including three-dimensionally arrayed channel networks
AU2001284896A1 (en) Deformable stamp for patterning three-dimensional surfaces
AU2001276031A1 (en) Branded channel
AU5499201A (en) Microfluidic devices
AU2001253535A1 (en) Channel dancer
AU2002213400A1 (en) Microvalve
AU2001281077A1 (en) Fibre channel switch
AU2001286965A1 (en) Sodium channel modulators
AU2001243553A1 (en) Microreactor
AU2001262722A1 (en) Micro-channel plate
AU2001286051A1 (en) Microfluidic
AU2001288517A1 (en) Microcavity-based optical channel router
AU2001295182A1 (en) Single channel reformatter
AU2001277155A1 (en) Architecture for building web applications
AU2001292030A1 (en) Antiparasitic compounds
AU2001291783A1 (en) Encryption
AU2001279143A1 (en) Metlblown web
AU2001244687A1 (en) Micro-array
AU2002245107A1 (en) Improved biochip
AU2001267746A1 (en) Packet routing
AU2002232866A1 (en) Thin silicon micromachined structures
AU2001264433A1 (en) Velocity measurement - flank shift
AU2001265329A1 (en) Enhanced channel adapter
AU2002223903A1 (en) Inlet for microfluidic devices