AU2001251649A1 - Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase - Google Patents

Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase

Info

Publication number
AU2001251649A1
AU2001251649A1 AU2001251649A AU5164901A AU2001251649A1 AU 2001251649 A1 AU2001251649 A1 AU 2001251649A1 AU 2001251649 A AU2001251649 A AU 2001251649A AU 5164901 A AU5164901 A AU 5164901A AU 2001251649 A1 AU2001251649 A1 AU 2001251649A1
Authority
AU
Australia
Prior art keywords
dihydro
naphthalene
inhibitors
farnesyl transferase
ras farnesyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001251649A
Inventor
Daniele Marie Leonard
Joseph Thomas Repine
Gordon William Rewcastle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of AU2001251649A1 publication Critical patent/AU2001251649A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
AU2001251649A 2000-04-17 2001-04-17 Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase Abandoned AU2001251649A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19748300P 2000-04-17 2000-04-17
US60197483 2000-04-17
PCT/US2001/012433 WO2001079179A2 (en) 2000-04-17 2001-04-17 Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase

Publications (1)

Publication Number Publication Date
AU2001251649A1 true AU2001251649A1 (en) 2001-10-30

Family

ID=22729592

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001251649A Abandoned AU2001251649A1 (en) 2000-04-17 2001-04-17 Dihydro-2h-naphthalene-1-one inhibitors of ras farnesyl transferase

Country Status (8)

Country Link
US (2) US20030232790A1 (en)
EP (1) EP1276724A2 (en)
JP (1) JP2003531142A (en)
AU (1) AU2001251649A1 (en)
BR (1) BR0110074A (en)
CA (1) CA2406032A1 (en)
MX (1) MXPA02008536A (en)
WO (1) WO2001079179A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2095819A1 (en) * 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US576528A (en) * 1897-02-02 Alarm-clock
DE3424944A1 (en) * 1984-07-06 1986-02-06 Hoechst Ag, 6230 Frankfurt NEW IMIDAZOLY COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US5891889A (en) * 1996-04-03 1999-04-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5852010A (en) * 1996-04-03 1998-12-22 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5859035A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
ZA981080B (en) * 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase

Also Published As

Publication number Publication date
MXPA02008536A (en) 2002-12-13
CA2406032A1 (en) 2001-10-25
WO2001079179A3 (en) 2002-05-23
US20040171844A1 (en) 2004-09-02
JP2003531142A (en) 2003-10-21
US20030232790A1 (en) 2003-12-18
WO2001079179A2 (en) 2001-10-25
BR0110074A (en) 2002-12-31
EP1276724A2 (en) 2003-01-22

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