AU2001236678A1 - Adamantyl derivatives as anti-cancer agents - Google Patents

Adamantyl derivatives as anti-cancer agents

Info

Publication number
AU2001236678A1
AU2001236678A1 AU2001236678A AU3667801A AU2001236678A1 AU 2001236678 A1 AU2001236678 A1 AU 2001236678A1 AU 2001236678 A AU2001236678 A AU 2001236678A AU 3667801 A AU3667801 A AU 3667801A AU 2001236678 A1 AU2001236678 A1 AU 2001236678A1
Authority
AU
Australia
Prior art keywords
cancer agents
adamantyl derivatives
adamantyl
derivatives
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001236678A
Other languages
English (en)
Inventor
Xian-Ping Lu
Magnus Pfahl
Darryl Rideout
Hongyue Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Publication of AU2001236678A1 publication Critical patent/AU2001236678A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AU2001236678A 2000-02-04 2001-02-05 Adamantyl derivatives as anti-cancer agents Abandoned AU2001236678A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/498,347 2000-02-04
US09/498,347 US6462064B1 (en) 1996-07-08 2000-02-04 Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias
PCT/US2001/003717 WO2001056563A1 (en) 2000-02-04 2001-02-05 Adamantyl derivatives as anti-cancer agents

Publications (1)

Publication Number Publication Date
AU2001236678A1 true AU2001236678A1 (en) 2001-08-14

Family

ID=23980692

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001236678A Abandoned AU2001236678A1 (en) 2000-02-04 2001-02-05 Adamantyl derivatives as anti-cancer agents

Country Status (5)

Country Link
US (2) US6462064B1 (ja)
EP (1) EP1272176A4 (ja)
JP (1) JP2003521513A (ja)
AU (1) AU2001236678A1 (ja)
WO (1) WO2001056563A1 (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005516908A (ja) * 2001-11-30 2005-06-09 ザ バーナム インスティチュート 癌細胞におけるアポトーシスの誘導
US7449480B2 (en) * 2002-05-14 2008-11-11 Baylor College Of Medicine Small molecule inhibitors of HER2 expression
EP1509226A4 (en) * 2002-05-14 2008-04-09 Baylor College Medicine SMALL MOLECULAR INHIBITORS OF THE HER2 EXPRESSION
EP1572176A2 (en) * 2002-12-12 2005-09-14 Galderma Research & Development, S.N.C. Aqueous-alcoholic depigmenting gel containing a phenolic derivative and a retinoid
US6984508B2 (en) * 2003-06-11 2006-01-10 Ultra Biotech Limited Biological compositions and methods for treatment of cervical cancer
MX2007015679A (es) * 2005-06-30 2008-02-21 Amgen Inc Inhibidores de quinasa bis-aril y su uso en el tratamiento de inflamacion, angiogenesis y cancer.
US20110040115A1 (en) * 2005-12-02 2011-02-17 Finorga Sas Intermediates and process for the preparation of aromatic derivatives of 1-adamantane
WO2007130469A2 (en) * 2006-05-02 2007-11-15 Ordway Research Institute, Inc. Induction of intracellular and secreted growth inhibitors and paracrine tumor-suppressive activity by rar ligands
LV13737B (en) * 2006-12-28 2008-10-20 Vjaceslavs Tribulovics Method for manufacturing 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid
PT2125697T (pt) * 2007-01-15 2016-10-18 Yu Chongxi Pró-fármacos solúveis em água positivamente carregados de retinóides e compostos tipo retinóide com taxas de penetração na pele muito altas
US7858666B2 (en) 2007-06-08 2010-12-28 Mannkind Corporation IRE-1α inhibitors
JP2010539245A (ja) * 2007-09-14 2010-12-16 日東電工株式会社 薬物担体
IN266834B (ja) * 2008-03-17 2015-06-05 Glenmark Pharmaceuticals Sa
KR101576235B1 (ko) * 2012-11-30 2015-12-11 한국생명공학연구원 신규한 이치환 아다만틸 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 전이 억제용 약학적 조성물
US20140213651A1 (en) * 2013-01-31 2014-07-31 Biodelight Biotech Inc. Novel Use of Adapalene in Treating Cancer
KR102359435B1 (ko) * 2015-03-31 2022-02-09 (주)아모레퍼시픽 5-아다만탄-1-일-n-(2,4-다이하이드록시벤질)-2,4-다이메톡시벤즈아마이드를 함유하는 항염 조성물
US20170181988A1 (en) * 2015-12-23 2017-06-29 Cipla Limited Methods for the treatment of bladder cancer
EP3301085A1 (en) 2016-09-29 2018-04-04 Biogem S.Ca.R.L. Retinoid derivatives with antitumor activity
US11278025B2 (en) 2017-05-17 2022-03-22 The General Hospital Corporation Antibiotic compounds
WO2019018185A1 (en) 2017-07-15 2019-01-24 Arisan Therapeutics Inc. ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS
IT201900003343A1 (it) 2019-03-07 2020-09-07 Special Product’S Line S P A Derivati fenolici per uso come antimicrobici, antibatterici, battericidi
IT202000029912A1 (it) 2020-12-04 2022-06-04 Special Product’S Line S P A Derivati fenolici per uso come antimicrobici, antibatterici, battericidi
IT202000029906A1 (it) 2020-12-04 2022-06-04 Special Product’S Line S P A Derivati fenolici per uso come antimicrobici, antibatterici, battericidi.
IT202000029882A1 (it) 2020-12-04 2022-06-04 Special Product’S Line S P A Derivati fenolici per uso come antimicrobici, antibatterici, battericidi
WO2022229017A1 (en) 2021-04-27 2022-11-03 Biogem S.C.A R.L. Adamantyl retinoid derivative with anticancer activity
CN113925868A (zh) * 2021-11-19 2022-01-14 上海市同仁医院 一种神经酰胺在制备抗肿瘤药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK155079A (da) 1978-04-14 1979-10-15 Sumitomo Chemical Co Fremgangsmaade til fremstilling af tricycliske broforbindelser
DE3026579A1 (de) 1980-07-14 1982-02-11 Kali-Chemie Pharma Gmbh, 3000 Hannover 2,9-dioxatricyclo (4,3,1,o(pfeil hoch)3,7(pfeil hoch)) decane
US5098929A (en) 1985-07-30 1992-03-24 The Wellcome Foundation Limited Pesticidal compounds
DE3627679A1 (de) 1986-08-14 1988-02-25 Blaupunkt Werke Gmbh Filteranordnung
FR2636061B1 (fr) * 1988-09-07 1990-11-09 Cird Procede de preparation de derives de l'adamantane-1
FR2649976B1 (fr) * 1989-07-20 1991-09-27 Cird Nouveau compose marque au tritium, sa preparation et son application notamment dans le reperage des recepteurs nucleaires des retinoides
FR2676052B1 (fr) * 1991-05-02 1994-04-29 Cird Galderma Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique.
US5770382A (en) 1994-12-30 1998-06-23 Ligand Pharmaceuticals, Inc. Tricyclic retinoids, methods for their production and use
EP0850067A4 (en) 1995-07-17 1999-12-15 Cird Galderma METHOD FOR CANCER TREATMENT USING 6- (3- (1-ADAMANTYL) -4-HYDROXYPHENYL) 2 NAPHTALINE CARBONIC ACID
FR2741876B1 (fr) 1995-12-01 1998-01-09 Cird Galderma Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations
ATE284213T1 (de) * 1996-07-08 2004-12-15 Galderma Res & Dev Apoptose induzierende adamantyl-derivate und deren verwendung als antikrebsmittel
US5888432A (en) 1996-12-23 1999-03-30 Corning Incorporated 2-Adamantyl benzopyrans the compositions and (co)polymer matrices containing them
US5919970A (en) 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity

Also Published As

Publication number Publication date
EP1272176A4 (en) 2004-12-29
US20030073745A1 (en) 2003-04-17
WO2001056563A9 (en) 2002-10-31
EP1272176A1 (en) 2003-01-08
WO2001056563A1 (en) 2001-08-09
JP2003521513A (ja) 2003-07-15
US6825226B2 (en) 2004-11-30
US6462064B1 (en) 2002-10-08

Similar Documents

Publication Publication Date Title
AU2001236678A1 (en) Adamantyl derivatives as anti-cancer agents
AU2001280099A1 (en) 4-acylaminopyrazole derivatives
AU2001252463A1 (en) Thiophene derivatives useful as anticancer agents
AU2001230584A1 (en) 1h-imidazopyridine derivatives
GB0107758D0 (en) Anti-cancer compounds
AU2002224595A1 (en) Antitumor agents
AU2001230537A1 (en) Pyridoxazine derivatives
AU2002224038A1 (en) Benzimidazole derivatives
AU2001281802A1 (en) 6-phenylpyrrolopyrimidinedione derivatives
AU2001278790A1 (en) 1h-imidazopyridine derivatives
AU2001264280A1 (en) Vitamin D derivatives
AU2001278694A1 (en) Avermectin derivatives
AU2002213978A1 (en) Substituted C-cyclohexylmethylamine derivatives
AU2002212301A1 (en) Diazacycloalkanedione derivatives
AU4890301A (en) 6-methylnicotinamide derivatives as antiviral agents
AU2002212959A1 (en) Cycloalkylfluorosulfonamide derivatives
AU2001248777A1 (en) Vitamin d derivatives
AU2002215212A1 (en) 1-methylcarbapenem derivatives
AU2001289937A1 (en) Substituted 1-aminobutan-3-ol derivatives
AU2001254661A1 (en) Aminosulfonylbiphenyl derivatives
AU2001230565A1 (en) Perfluoroisopropylbenzene derivatives
AU2001234313A1 (en) Novel phenylheteroalkylamine derivatives
AU3430699A (en) Butenolide derivatives as anti-cancer agents
AU2001242772A1 (en) 3-substituted-4-pyrimidone derivatives
AU2001262489A1 (en) Triterpenoid derivatives