ATE965T1 - AMINOPROPANOL DERIVATIVES OF 2-(O-HYDROXYPHENYL)-PYRROLE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. - Google Patents

AMINOPROPANOL DERIVATIVES OF 2-(O-HYDROXYPHENYL)-PYRROLE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

Info

Publication number
ATE965T1
ATE965T1 AT79102837T AT79102837T ATE965T1 AT E965 T1 ATE965 T1 AT E965T1 AT 79102837 T AT79102837 T AT 79102837T AT 79102837 T AT79102837 T AT 79102837T AT E965 T1 ATE965 T1 AT E965T1
Authority
AT
Austria
Prior art keywords
carbon atoms
pyrrole
hydroxyphenyl
manufacture
cycloalkyl
Prior art date
Application number
AT79102837T
Other languages
German (de)
Inventor
Fritz-Frieder Dr. Chem. Frickel
Albrecht Dr. Chem. Franke
Horst Dr. Chem. Koenig
Hans-Dieter Dr. Lenke
Josef Dr. Gries
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Application granted granted Critical
Publication of ATE965T1 publication Critical patent/ATE965T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Alkylaminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrrole of the formula (I) <IMAGE> (I) where R is hydrogen or is alkyl of 1 to 8 carbon atoms which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbons atoms or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or monosubstituted or disubstituted by alkyl or 1 to 3 carbon atoms, and their physiologically acceptable acid addition salts, processes for their preparation, and pharmaceutical formulations which contain the said compounds and may be used in the treatment of cardiac and circulatory disorders.
AT79102837T 1978-08-12 1979-08-07 AMINOPROPANOL DERIVATIVES OF 2-(O-HYDROXYPHENYL)-PYRROLE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. ATE965T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782835438 DE2835438A1 (en) 1978-08-12 1978-08-12 AMINOPROPANOL DERIVATIVES OF 2- (O-HYDROXYPHENYL) PYRROL
EP79102837A EP0008108B1 (en) 1978-08-12 1979-08-07 Aminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrroles, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE965T1 true ATE965T1 (en) 1982-05-15

Family

ID=6046918

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102837T ATE965T1 (en) 1978-08-12 1979-08-07 AMINOPROPANOL DERIVATIVES OF 2-(O-HYDROXYPHENYL)-PYRROLE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

Country Status (5)

Country Link
US (1) US4267187A (en)
EP (1) EP0008108B1 (en)
JP (1) JPS5527195A (en)
AT (1) ATE965T1 (en)
DE (2) DE2835438A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3343671A1 (en) * 1983-12-02 1985-06-20 Basf Ag, 6700 Ludwigshafen AMINOPROPANOL DERIVATIVES OF SUBSTITUTED 2-HYDROXY-PROPIOPHENONES, METHOD FOR THE PRODUCTION THEREOF AND THERAPEUTIC AGENTS CONTAINING THEM
EP0265388A1 (en) * 1986-10-24 1988-04-27 Ciba-Geigy Ag Pyrrole derivatives, therapeutic compositions containing them and their use
GB9325827D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Plc Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH575924A5 (en) * 1973-03-09 1976-05-31 Ciba Geigy Ag Pyrrolylphenoxy propanolamine derivs - with anti-excitatory and adrenergic beta-receptor blocking activity
CH579045A5 (en) * 1973-03-09 1976-08-31 Ciba Geigy Ag Pyrrolylphenoxy propanolamine derivs - with anti-excitatory and adrenergic beta-receptor blocking activity
CH579046A5 (en) * 1973-03-09 1976-08-31 Ciba Geigy Ag Pyrrolylphenoxy propanolamine derivs - with anti-excitatory and adrenergic beta-receptor blocking activity
CH575922A5 (en) * 1973-03-09 1976-05-31 Ciba Geigy Ag Pyrrolylphenoxy propanolamine derivs - with anti-excitatory and adrenergic beta-receptor blocking activity
CH575923A5 (en) * 1973-03-09 1976-05-31 Ciba Geigy Ag Pyrrolylphenoxy propanolamine derivs - with anti-excitatory and adrenergic beta-receptor blocking activity

Also Published As

Publication number Publication date
DE2962700D1 (en) 1982-06-24
US4267187A (en) 1981-05-12
JPS5527195A (en) 1980-02-27
EP0008108B1 (en) 1982-05-05
DE2835438A1 (en) 1980-03-06
EP0008108A2 (en) 1980-02-20
EP0008108A3 (en) 1980-03-05

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