ATE90102T1 - Angstloesende und antidepressive tetrahydrobenzothienopyridinderivate. - Google Patents
Angstloesende und antidepressive tetrahydrobenzothienopyridinderivate.Info
- Publication number
- ATE90102T1 ATE90102T1 AT89300516T AT89300516T ATE90102T1 AT E90102 T1 ATE90102 T1 AT E90102T1 AT 89300516 T AT89300516 T AT 89300516T AT 89300516 T AT89300516 T AT 89300516T AT E90102 T1 ATE90102 T1 AT E90102T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- phenyl
- alkanoyl
- optionally substituted
- hydrogen
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 title abstract 2
- 230000036506 anxiety Effects 0.000 title abstract 2
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- -1 nitro, amino Chemical group 0.000 abstract 9
- 125000001589 carboacyl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888801491A GB8801491D0 (en) | 1988-01-22 | 1988-01-22 | Novel compounds |
| EP89300516A EP0327223B1 (de) | 1988-01-22 | 1989-01-19 | Angstlösende und antidepressive Tetrahydrobenzothienopyridinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE90102T1 true ATE90102T1 (de) | 1993-06-15 |
Family
ID=10630405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89300516T ATE90102T1 (de) | 1988-01-22 | 1989-01-19 | Angstloesende und antidepressive tetrahydrobenzothienopyridinderivate. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5093493A (de) |
| EP (1) | EP0327223B1 (de) |
| JP (1) | JPH01242586A (de) |
| KR (1) | KR890011891A (de) |
| AT (1) | ATE90102T1 (de) |
| AU (1) | AU618571B2 (de) |
| DE (1) | DE68906803T2 (de) |
| DK (1) | DK26689A (de) |
| GB (1) | GB8801491D0 (de) |
| IE (1) | IE890174L (de) |
| NZ (1) | NZ227685A (de) |
| PT (1) | PT89490B (de) |
| ZA (1) | ZA89472B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2844354B2 (ja) * | 1989-08-03 | 1999-01-06 | 富士薬品工業株式会社 | Ｄ―パントラクトンの製造法 |
| AU6368090A (en) * | 1989-10-03 | 1991-04-11 | Warner-Lambert Company | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity |
| GB9010296D0 (en) * | 1990-05-08 | 1990-06-27 | Beecham Group Plc | Novel compounds |
| GB9117459D0 (en) * | 1991-08-13 | 1991-09-25 | Smithkline Beecham Plc | Novel compounds |
| MX9206365A (es) * | 1991-11-07 | 1994-02-28 | Smithkline Beecham Plc | Tetrahidrobenzotienopiridinas,proceso para su preparacion y composicion farmaceutica que las contiene |
| GB9127188D0 (en) * | 1991-12-21 | 1992-02-19 | Smithkline Beecham Plc | Novel compounds |
| GR920100421A (el) * | 1992-10-08 | 1994-06-30 | Smithkline Beecham Plc | Τετραυδροβενζοθειενοπυριδινες εχουσα δραση κ.ν.ς. |
| WO1994018205A1 (en) * | 1993-02-11 | 1994-08-18 | Smithkline Beecham Plc | C.n.s. active tetrahydrobenzothienopyridines |
| GB9309179D0 (en) * | 1993-05-05 | 1993-06-16 | Smithkline Beecham Plc | New use |
| RU2196772C1 (ru) * | 2001-10-08 | 2003-01-20 | Кубанский государственный технологический университет | 6-МЕТИЛ-8-МЕТОКСИМЕТИЛ-3-ФЕНИЛИЗОКСАЗОЛО[3',4':4,5]ТИЕНО-[2,3-b]ПИРИДИН, ПРОЯВЛЯЮЩИЙ РОСТОРЕГУЛИРУЮЩУЮ И АНТИСТРЕССОВУЮ АКТИВНОСТЬ |
| US7638519B2 (en) * | 2003-12-23 | 2009-12-29 | Myogen, Inc. | Compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease |
| EP1828199B1 (de) * | 2004-12-17 | 2009-05-06 | F. Hoffmann-Roche AG | Thienopyridinderivate als allostere gaba-b-enhancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2435025C2 (de) * | 1973-07-23 | 1985-01-17 | Takeda Chemical Industries, Ltd., Osaka | 4,7-Dihydro-4-oxo-thieno-[2,3-b]pyridin-5-carbonsäure und deren Derivate und Verfahren zu deren Herstellung |
| EP0126970A3 (de) * | 1983-04-27 | 1985-11-06 | Beecham Group Plc | Anxiolytische und anti-depressante Thienopyridinderivate |
| JPS6210087A (ja) * | 1985-07-03 | 1987-01-19 | Shionogi & Co Ltd | ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤 |
| GB8600651D0 (en) * | 1986-01-11 | 1986-02-19 | Beecham Group Plc | Compounds |
-
1988
- 1988-01-22 GB GB888801491A patent/GB8801491D0/en active Pending
-
1989
- 1989-01-19 DE DE89300516T patent/DE68906803T2/de not_active Expired - Fee Related
- 1989-01-19 EP EP89300516A patent/EP0327223B1/de not_active Expired - Lifetime
- 1989-01-19 AT AT89300516T patent/ATE90102T1/de not_active IP Right Cessation
- 1989-01-20 IE IE890174A patent/IE890174L/xx unknown
- 1989-01-20 NZ NZ227685A patent/NZ227685A/xx unknown
- 1989-01-20 JP JP1011771A patent/JPH01242586A/ja active Pending
- 1989-01-20 DK DK026689A patent/DK26689A/da not_active Application Discontinuation
- 1989-01-20 PT PT89490A patent/PT89490B/pt not_active IP Right Cessation
- 1989-01-20 ZA ZA89472A patent/ZA89472B/xx unknown
- 1989-01-20 AU AU28667/89A patent/AU618571B2/en not_active Ceased
- 1989-01-21 KR KR1019890000667A patent/KR890011891A/ko not_active Withdrawn
-
1990
- 1990-03-12 US US07/494,792 patent/US5093493A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE68906803D1 (de) | 1993-07-08 |
| DK26689D0 (da) | 1989-01-20 |
| EP0327223B1 (de) | 1993-06-02 |
| PT89490B (pt) | 1993-12-31 |
| NZ227685A (en) | 1992-08-26 |
| KR890011891A (ko) | 1989-08-23 |
| DE68906803T2 (de) | 1993-12-23 |
| AU618571B2 (en) | 1992-01-02 |
| DK26689A (da) | 1989-07-23 |
| ZA89472B (en) | 1990-02-28 |
| PT89490A (pt) | 1989-10-04 |
| JPH01242586A (ja) | 1989-09-27 |
| GB8801491D0 (en) | 1988-02-24 |
| AU2866789A (en) | 1989-07-27 |
| IE890174L (en) | 1989-07-22 |
| EP0327223A1 (de) | 1989-08-09 |
| US5093493A (en) | 1992-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |