DK0563916T3 - (1H-Indol-1-yl)-2-(amino)acetamider og beslægtede (1H-indol-1-yl)-(alminoalkyl)amider, mellemprodukt er, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

(1H-Indol-1-yl)-2-(amino)acetamider og beslægtede (1H-indol-1-yl)-(alminoalkyl)amider, mellemprodukt er, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

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Publication number
DK0563916T3
DK0563916T3 DK93105332.6T DK93105332T DK0563916T3 DK 0563916 T3 DK0563916 T3 DK 0563916T3 DK 93105332 T DK93105332 T DK 93105332T DK 0563916 T3 DK0563916 T3 DK 0563916T3
Authority
DK
Denmark
Prior art keywords
loweralkyl
hydrogen
indol
bromo
chloro
Prior art date
Application number
DK93105332.6T
Other languages
English (en)
Inventor
Raymond W Kosley Jr
Denise M Flanagan
Lawrence Leo Martin
Peter Allen Nemoto
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of DK0563916T3 publication Critical patent/DK0563916T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK93105332.6T 1992-04-03 1993-03-31 (1H-Indol-1-yl)-2-(amino)acetamider og beslægtede (1H-indol-1-yl)-(alminoalkyl)amider, mellemprodukt er, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0563916T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/863,273 US5319096A (en) 1992-04-03 1992-04-03 (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use

Publications (1)

Publication Number Publication Date
DK0563916T3 true DK0563916T3 (da) 1995-12-04

Family

ID=25340739

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93105332.6T DK0563916T3 (da) 1992-04-03 1993-03-31 (1H-Indol-1-yl)-2-(amino)acetamider og beslægtede (1H-indol-1-yl)-(alminoalkyl)amider, mellemprodukt er, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (14)

Country Link
US (4) US5319096A (da)
EP (1) EP0563916B1 (da)
JP (1) JP2669765B2 (da)
KR (1) KR100286406B1 (da)
AT (1) ATE126505T1 (da)
AU (1) AU663363B2 (da)
CA (1) CA2093306C (da)
DE (1) DE69300373T2 (da)
DK (1) DK0563916T3 (da)
ES (1) ES2078082T3 (da)
GR (1) GR3017446T3 (da)
MX (1) MX9301889A (da)
NZ (1) NZ247298A (da)
TW (1) TW254935B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
US6137927A (en) * 1998-01-16 2000-10-24 Corning Incorporated N-port reconfigurable DWDM multiplexer and demultiplexer
JP2000264876A (ja) * 1998-09-10 2000-09-26 Sumitomo Chem Co Ltd 縮合複素環化合物
CA2363244C (en) * 2000-11-07 2006-06-13 Research In Motion Limited Multifunctional keyboard for a mobile communication device and method of operating the same
US6759427B2 (en) * 2001-04-20 2004-07-06 Spectrum Pharmaceuticals, Inc. Synthesis and methods of use of tetrahydroindolone analogues and derivatives
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
RU2283108C2 (ru) * 2003-12-08 2006-09-10 Сергей Олегович Бачурин ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
US20070179174A1 (en) * 2003-12-08 2007-08-02 Bachurin Sergei O Methods and compositions for slowing aging
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
WO2007041697A2 (en) * 2005-10-04 2007-04-12 Medivation, Inc. Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease
FR2926077A1 (fr) * 2008-01-04 2009-07-10 Servier Lab Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
US3903150A (en) * 1972-02-03 1975-09-02 Merck & Co Inc Process for preparing 3-fluoro-D-alanine
US4204998A (en) * 1974-03-28 1980-05-27 Siegfried Aktiengesellschaft N-Amino indole derivatives having pharmacological activity
US4496542A (en) * 1981-03-30 1985-01-29 Usv Pharmaceutical Corporation N-substituted-amido-amino acids
JPS60142955A (ja) * 1983-12-28 1985-07-29 Fuji Photo Film Co Ltd インド−ル誘導体の製造方法
US5017578A (en) * 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
ES2146578T3 (es) * 1990-05-10 2000-08-16 Pfizer Indolona neuroprotectora y derivados relacionados.
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates

Also Published As

Publication number Publication date
AU3565293A (en) 1993-10-07
EP0563916A1 (en) 1993-10-06
DE69300373T2 (de) 1996-02-29
US5591866A (en) 1997-01-07
ES2078082T3 (es) 1995-12-01
KR930021616A (ko) 1993-11-22
AU663363B2 (en) 1995-10-05
JPH0641069A (ja) 1994-02-15
EP0563916B1 (en) 1995-08-16
TW254935B (da) 1995-08-21
ATE126505T1 (de) 1995-09-15
GR3017446T3 (en) 1995-12-31
US5319096A (en) 1994-06-07
JP2669765B2 (ja) 1997-10-29
US5565579A (en) 1996-10-15
NZ247298A (en) 1995-03-28
MX9301889A (es) 1993-10-01
CA2093306C (en) 2005-09-27
KR100286406B1 (ko) 2001-04-16
CA2093306A1 (en) 1993-10-04
DE69300373D1 (de) 1995-09-21
US5646300A (en) 1997-07-08

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