DE68906803T2 - Angstlösende und antidepressive Tetrahydrobenzothienopyridinderivate. - Google Patents

Angstlösende und antidepressive Tetrahydrobenzothienopyridinderivate.

Info

Publication number
DE68906803T2
DE68906803T2 DE89300516T DE68906803T DE68906803T2 DE 68906803 T2 DE68906803 T2 DE 68906803T2 DE 89300516 T DE89300516 T DE 89300516T DE 68906803 T DE68906803 T DE 68906803T DE 68906803 T2 DE68906803 T2 DE 68906803T2
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
alkanoyl
optionally substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89300516T
Other languages
English (en)
Other versions
DE68906803D1 (de
Inventor
Mervyn Thompson
Ian Thomson Forbes
Christopher Norbert Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE68906803D1 publication Critical patent/DE68906803D1/de
Publication of DE68906803T2 publication Critical patent/DE68906803T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
DE89300516T 1988-01-22 1989-01-19 Angstlösende und antidepressive Tetrahydrobenzothienopyridinderivate. Expired - Fee Related DE68906803T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888801491A GB8801491D0 (en) 1988-01-22 1988-01-22 Novel compounds

Publications (2)

Publication Number Publication Date
DE68906803D1 DE68906803D1 (de) 1993-07-08
DE68906803T2 true DE68906803T2 (de) 1993-12-23

Family

ID=10630405

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89300516T Expired - Fee Related DE68906803T2 (de) 1988-01-22 1989-01-19 Angstlösende und antidepressive Tetrahydrobenzothienopyridinderivate.

Country Status (13)

Country Link
US (1) US5093493A (de)
EP (1) EP0327223B1 (de)
JP (1) JPH01242586A (de)
KR (1) KR890011891A (de)
AT (1) ATE90102T1 (de)
AU (1) AU618571B2 (de)
DE (1) DE68906803T2 (de)
DK (1) DK26689A (de)
GB (1) GB8801491D0 (de)
IE (1) IE890174L (de)
NZ (1) NZ227685A (de)
PT (1) PT89490B (de)
ZA (1) ZA89472B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2844354B2 (ja) * 1989-08-03 1999-01-06 富士薬品工業株式会社 Ｄ―パントラクトンの製造法
AU6368090A (en) * 1989-10-03 1991-04-11 Warner-Lambert Company Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity
GB9010296D0 (en) * 1990-05-08 1990-06-27 Beecham Group Plc Novel compounds
GB9117459D0 (en) * 1991-08-13 1991-09-25 Smithkline Beecham Plc Novel compounds
WO1993009122A1 (en) * 1991-11-07 1993-05-13 Smithkline Beecham Plc Cns active tetrahydrobenzothienopyridines
GB9127188D0 (en) * 1991-12-21 1992-02-19 Smithkline Beecham Plc Novel compounds
GR920100421A (el) * 1992-10-08 1994-06-30 Smithkline Beecham Plc Τετραυδροβενζοθειενοπυριδινες εχουσα δραση κ.ν.ς.
WO1994018205A1 (en) * 1993-02-11 1994-08-18 Smithkline Beecham Plc C.n.s. active tetrahydrobenzothienopyridines
GB9309179D0 (en) * 1993-05-05 1993-06-16 Smithkline Beecham Plc New use
US7638519B2 (en) * 2003-12-23 2009-12-29 Myogen, Inc. Compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
CA2591211A1 (en) * 2004-12-17 2006-06-22 Parichehr Malherbe Thieno-pyridine derivatives as gaba-b allosteric enhancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2435025C2 (de) * 1973-07-23 1985-01-17 Takeda Chemical Industries, Ltd., Osaka 4,7-Dihydro-4-oxo-thieno-[2,3-b]pyridin-5-carbonsäure und deren Derivate und Verfahren zu deren Herstellung
EP0126970A3 (de) * 1983-04-27 1985-11-06 Beecham Group Plc Anxiolytische und anti-depressante Thienopyridinderivate
JPS6210087A (ja) * 1985-07-03 1987-01-19 Shionogi & Co Ltd ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤
GB8600651D0 (en) * 1986-01-11 1986-02-19 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
EP0327223B1 (de) 1993-06-02
AU618571B2 (en) 1992-01-02
DK26689D0 (da) 1989-01-20
GB8801491D0 (en) 1988-02-24
ATE90102T1 (de) 1993-06-15
AU2866789A (en) 1989-07-27
PT89490A (pt) 1989-10-04
NZ227685A (en) 1992-08-26
KR890011891A (ko) 1989-08-23
IE890174L (en) 1989-07-22
PT89490B (pt) 1993-12-31
DE68906803D1 (de) 1993-07-08
EP0327223A1 (de) 1989-08-09
JPH01242586A (ja) 1989-09-27
US5093493A (en) 1992-03-03
DK26689A (da) 1989-07-23
ZA89472B (en) 1990-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee