ATE89567T1 - CONJUGATES OF VINBLASTINE AND ITS DERIVATIVES, PROCESSES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE CONJUGATES. - Google Patents

CONJUGATES OF VINBLASTINE AND ITS DERIVATIVES, PROCESSES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE CONJUGATES.

Info

Publication number
ATE89567T1
ATE89567T1 AT86870042T AT86870042T ATE89567T1 AT E89567 T1 ATE89567 T1 AT E89567T1 AT 86870042 T AT86870042 T AT 86870042T AT 86870042 T AT86870042 T AT 86870042T AT E89567 T1 ATE89567 T1 AT E89567T1
Authority
AT
Austria
Prior art keywords
conjugates
vinblastine
image
derivatives
group
Prior art date
Application number
AT86870042T
Other languages
German (de)
Inventor
Andre Benoit Leon Trouet
Kandukuri Sivaprasade Bush Rao
Jean-Alfred Alphonse Hannart
Jean-Paul Dejonghe
Original Assignee
Wallone Region
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU86157A external-priority patent/LU86157A1/en
Application filed by Wallone Region filed Critical Wallone Region
Application granted granted Critical
Publication of ATE89567T1 publication Critical patent/ATE89567T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Previously unknown conjugates of vinblastine, or derivatives thereof, have the general formula <IMAGE> where A denotes an "arm" such as <IMAGE> or <IMAGE> where n is an integer from 1-5 and R is a hydrogen atom or an acyl group, R1 is an optionally modified protein radical, R2 is a methoxy group, an amino group or an α-amino acid ester which is bonded using a bond of the amide type and where the ester group contains 1-6 carbon atoms, and where R3 is a hydrogen atom or an hydroxyl group and is in all cases in the two possible configurations. These conjugates have a powerful effect when treating leukaemias, lymphosarcomas and other malignant tumours, including the so-called "solid" tumours, and when treating Hodgkin's disease.
AT86870042T 1985-11-12 1986-04-08 CONJUGATES OF VINBLASTINE AND ITS DERIVATIVES, PROCESSES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE CONJUGATES. ATE89567T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU86157A LU86157A1 (en) 1985-11-12 1985-11-12 NEW PROCESS FOR THE MANUFACTURE OF VINBLASTIN CONJUGATES AND DERIVATIVES THEREOF
EP86870042A EP0222722B1 (en) 1985-11-12 1986-04-08 Conjugates of vinblastine and its derivatives, process for preparing them and pharmaceutical compositions containing these conjugates

Publications (1)

Publication Number Publication Date
ATE89567T1 true ATE89567T1 (en) 1993-06-15

Family

ID=26106792

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86870042T ATE89567T1 (en) 1985-11-12 1986-04-08 CONJUGATES OF VINBLASTINE AND ITS DERIVATIVES, PROCESSES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE CONJUGATES.

Country Status (6)

Country Link
AT (1) ATE89567T1 (en)
AU (1) AU577206B2 (en)
DK (1) DK164107C (en)
GR (1) GR862436B (en)
HU (1) HU196217B (en)
OA (1) OA08424A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508905B1 (en) * 1981-07-01 1984-01-27 Roussel Uclaf
CA1285866C (en) * 1984-10-19 1991-07-09 Akiko Kubodera Immunoassay for estriol-3-sulfate
ZA873600B (en) * 1986-05-27 1988-12-28 Lilly Co Eli Immunoglobulin conjugates
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (en) * 1983-04-29 1984-12-12 Omnichem Sa

Also Published As

Publication number Publication date
GR862436B (en) 1986-12-23
AU6340186A (en) 1988-04-14
HUT42493A (en) 1987-07-28
DK164107C (en) 1992-10-05
HU196217B (en) 1988-10-28
DK473286A (en) 1987-05-13
OA08424A (en) 1988-06-30
DK164107B (en) 1992-05-11
DK473286D0 (en) 1986-10-03
AU577206B2 (en) 1988-09-15

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties