EA199800368A1 - NEW INTERMEDIATE PRODUCTS AND THEIR USE TO RECEIVE N, N'-MOSTIC BISINDOLYLMYLEIMIDES - Google Patents

NEW INTERMEDIATE PRODUCTS AND THEIR USE TO RECEIVE N, N'-MOSTIC BISINDOLYLMYLEIMIDES

Info

Publication number
EA199800368A1
EA199800368A1 EA199800368A EA199800368A EA199800368A1 EA 199800368 A1 EA199800368 A1 EA 199800368A1 EA 199800368 A EA199800368 A EA 199800368A EA 199800368 A EA199800368 A EA 199800368A EA 199800368 A1 EA199800368 A1 EA 199800368A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mostic
bisindolylmyleimides
receive
intermediate products
new intermediate
Prior art date
Application number
EA199800368A
Other languages
Russian (ru)
Other versions
EA000639B1 (en
Inventor
Маргарет М. Фол
Кристин А. Крумрич
Леонард Л. мл. Виннероски
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21725638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199800368(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199800368A1 publication Critical patent/EA199800368A1/en
Publication of EA000639B1 publication Critical patent/EA000639B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Данное изобретение относится к соединениям формулы (II)Далее изобретение относится к использованию этого соединения для получения N,N'-мостиковых бис-индолилмалеимидов. Кроме того, изобретение относится к фармацевтическим готовым препаративным формам и способам использования для ингибирования протеинкиназы С в млекопитающих.Международная заявка была опубликована вместе с отчетом о международном поиске.This invention relates to compounds of formula (II) Further, the invention relates to the use of this compound for the preparation of N, N'-bridged bis-indolylmaleimides. In addition, the invention relates to pharmaceutical formulations and methods of use for inhibiting protein kinase C in mammals. The international application has been published along with an international search report.

EA199800368A 1995-11-20 1996-11-18 Novel intermediates and their use to prepare n,n'-bridged bisindolymaleimides EA000639B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US734595P 1995-11-20 1995-11-20
PCT/US1996/018518 WO1997019080A1 (en) 1995-11-20 1996-11-18 Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides

Publications (2)

Publication Number Publication Date
EA199800368A1 true EA199800368A1 (en) 1998-12-24
EA000639B1 EA000639B1 (en) 1999-12-29

Family

ID=21725638

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800368A EA000639B1 (en) 1995-11-20 1996-11-18 Novel intermediates and their use to prepare n,n'-bridged bisindolymaleimides

Country Status (31)

Country Link
EP (1) EP0776899B1 (en)
JP (2) JP4100708B2 (en)
KR (1) KR100342142B1 (en)
CN (1) CN1066734C (en)
AR (2) AR004719A1 (en)
AT (1) ATE191219T1 (en)
AU (1) AU701659B2 (en)
BR (1) BR9611709A (en)
CA (1) CA2237401C (en)
CO (1) CO4750824A1 (en)
CZ (1) CZ150398A3 (en)
DE (1) DE69607443T2 (en)
DK (1) DK0776899T3 (en)
EA (1) EA000639B1 (en)
ES (1) ES2145978T3 (en)
GR (1) GR3033729T3 (en)
HU (1) HU225716B1 (en)
IL (1) IL124415A (en)
MX (1) MX9803791A (en)
MY (1) MY118946A (en)
NO (1) NO310195B1 (en)
NZ (1) NZ323282A (en)
PE (1) PE17998A1 (en)
PL (1) PL184728B1 (en)
PT (1) PT776899E (en)
TR (1) TR199800876T2 (en)
TW (1) TW371661B (en)
UA (1) UA56145C2 (en)
WO (1) WO1997019080A1 (en)
YU (1) YU49316B (en)
ZA (1) ZA969645B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
EP1070068B2 (en) * 1998-03-13 2007-01-17 The University Of British Columbia Granulatimide derivatives for use in cancer treatment
US6127401A (en) 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6300106B1 (en) 2000-11-22 2001-10-09 Ppg Industries Ohio, Inc. Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
EP2181999A1 (en) 2008-11-03 2010-05-05 Zentiva, A.S. Method of manufacturing ruboxistarin
WO2023192984A1 (en) * 2022-03-31 2023-10-05 4M Therapeutics Inc. N-desmethyl ruboxistaurin as kinase inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DK0657458T3 (en) * 1993-12-07 2001-10-29 Lilly Co Eli Inhibitors of protein kinase-C
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
TR199800876T2 (en) 1998-08-21
HU225716B1 (en) 2007-07-30
BR9611709A (en) 1999-02-23
IL124415A0 (en) 1998-12-06
CZ150398A3 (en) 1998-12-16
AU7738896A (en) 1997-06-11
CA2237401A1 (en) 1997-05-29
KR19990067600A (en) 1999-08-25
WO1997019080A1 (en) 1997-05-29
NZ323282A (en) 1999-01-28
ATE191219T1 (en) 2000-04-15
YU61096A (en) 1999-03-04
EP0776899B1 (en) 2000-03-29
EA000639B1 (en) 1999-12-29
AU701659B2 (en) 1999-02-04
PL184728B1 (en) 2002-12-31
HUP9901975A2 (en) 1999-11-29
EP0776899A1 (en) 1997-06-04
MY118946A (en) 2005-02-28
AR004718A1 (en) 1999-03-10
NO982105D0 (en) 1998-05-08
CN1066734C (en) 2001-06-06
HUP9901975A3 (en) 2000-01-28
YU49316B (en) 2005-06-10
DK0776899T3 (en) 2000-07-10
CN1207740A (en) 1999-02-10
CA2237401C (en) 2003-10-21
AR004719A1 (en) 1999-03-10
IL124415A (en) 2003-11-23
NO982105L (en) 1998-05-08
JP2008138006A (en) 2008-06-19
PE17998A1 (en) 1998-04-20
ZA969645B (en) 1998-05-18
MX9803791A (en) 1998-09-30
ES2145978T3 (en) 2000-07-16
JP4100708B2 (en) 2008-06-11
KR100342142B1 (en) 2002-08-22
CO4750824A1 (en) 1999-03-31
NO310195B1 (en) 2001-06-05
DE69607443T2 (en) 2000-08-10
PL326753A1 (en) 1998-10-26
PT776899E (en) 2000-08-31
TW371661B (en) 1999-10-11
JP2000500496A (en) 2000-01-18
DE69607443D1 (en) 2000-05-04
GR3033729T3 (en) 2000-10-31
UA56145C2 (en) 2003-05-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU