AU6340186A - Conjugates of vinblastine and protein - Google Patents

Conjugates of vinblastine and protein

Info

Publication number
AU6340186A
AU6340186A AU63401/86A AU6340186A AU6340186A AU 6340186 A AU6340186 A AU 6340186A AU 63401/86 A AU63401/86 A AU 63401/86A AU 6340186 A AU6340186 A AU 6340186A AU 6340186 A AU6340186 A AU 6340186A
Authority
AU
Australia
Prior art keywords
conjugates
image
group
vinblastine
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU63401/86A
Other versions
AU577206B2 (en
Inventor
Jean-Paul Dejonghe
Jean Alfred Alphonse Hannart
Kandukuri Sivaprasade Bushana Rao
Andre Benoit Lenon Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Omnichem NV SA
Original Assignee
Omnichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU86157A external-priority patent/LU86157A1/en
Application filed by Omnichem SA filed Critical Omnichem SA
Publication of AU6340186A publication Critical patent/AU6340186A/en
Application granted granted Critical
Publication of AU577206B2 publication Critical patent/AU577206B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Previously unknown conjugates of vinblastine, or derivatives thereof, have the general formula <IMAGE> where A denotes an "arm" such as <IMAGE> or <IMAGE> where n is an integer from 1-5 and R is a hydrogen atom or an acyl group, R1 is an optionally modified protein radical, R2 is a methoxy group, an amino group or an α-amino acid ester which is bonded using a bond of the amide type and where the ester group contains 1-6 carbon atoms, and where R3 is a hydrogen atom or an hydroxyl group and is in all cases in the two possible configurations. These conjugates have a powerful effect when treating leukaemias, lymphosarcomas and other malignant tumours, including the so-called "solid" tumours, and when treating Hodgkin's disease.
AU63401/86A 1985-11-12 1986-09-30 Conjugates of vinblastine and protein Ceased AU577206B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU86157A LU86157A1 (en) 1985-11-12 1985-11-12 NEW PROCESS FOR THE MANUFACTURE OF VINBLASTIN CONJUGATES AND DERIVATIVES THEREOF
LU86517 1985-11-12
EP86870042 1986-04-08
EP86870042A EP0222722B1 (en) 1985-11-12 1986-04-08 Conjugates of vinblastine and its derivatives, process for preparing them and pharmaceutical compositions containing these conjugates

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU27434/84A Addition AU575819B2 (en) 1983-04-29 1984-04-27 Vinblastine conjugates

Publications (2)

Publication Number Publication Date
AU6340186A true AU6340186A (en) 1988-04-14
AU577206B2 AU577206B2 (en) 1988-09-15

Family

ID=26106792

Family Applications (1)

Application Number Title Priority Date Filing Date
AU63401/86A Ceased AU577206B2 (en) 1985-11-12 1986-09-30 Conjugates of vinblastine and protein

Country Status (6)

Country Link
AT (1) ATE89567T1 (en)
AU (1) AU577206B2 (en)
DK (1) DK164107C (en)
GR (1) GR862436B (en)
HU (1) HU196217B (en)
OA (1) OA08424A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU590731B2 (en) * 1984-10-19 1989-11-16 Nihon Medi-Physics Co., Ltd. Estriol-3-sulfate protein conjugates and antibodies thereto
AU599603B2 (en) * 1981-07-01 1990-07-26 Roussel-Uclaf Process for preparation of antigens using radio active stilbene derivatives labelled with iodine and the antigens obtained
AU600727B2 (en) * 1986-05-27 1990-08-23 Eli Lilly And Company Immunoglobulin conjugates
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (en) * 1983-04-29 1984-12-12 Omnichem Sa

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599603B2 (en) * 1981-07-01 1990-07-26 Roussel-Uclaf Process for preparation of antigens using radio active stilbene derivatives labelled with iodine and the antigens obtained
AU590731B2 (en) * 1984-10-19 1989-11-16 Nihon Medi-Physics Co., Ltd. Estriol-3-sulfate protein conjugates and antibodies thereto
AU600727B2 (en) * 1986-05-27 1990-08-23 Eli Lilly And Company Immunoglobulin conjugates
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers

Also Published As

Publication number Publication date
GR862436B (en) 1986-12-23
HUT42493A (en) 1987-07-28
DK164107C (en) 1992-10-05
HU196217B (en) 1988-10-28
DK473286A (en) 1987-05-13
OA08424A (en) 1988-06-30
ATE89567T1 (en) 1993-06-15
DK164107B (en) 1992-05-11
DK473286D0 (en) 1986-10-03
AU577206B2 (en) 1988-09-15

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