DK473286A - CONJUGATES OF VINBLASTIN AND DERIVATIVES THEREOF, PROCEDURES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM - Google Patents
CONJUGATES OF VINBLASTIN AND DERIVATIVES THEREOF, PROCEDURES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM Download PDFInfo
- Publication number
- DK473286A DK473286A DK473286A DK473286A DK473286A DK 473286 A DK473286 A DK 473286A DK 473286 A DK473286 A DK 473286A DK 473286 A DK473286 A DK 473286A DK 473286 A DK473286 A DK 473286A
- Authority
- DK
- Denmark
- Prior art keywords
- conjugates
- image
- group
- derivatives
- vinblastin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Previously unknown conjugates of vinblastine, or derivatives thereof, have the general formula <IMAGE> where A denotes an "arm" such as <IMAGE> or <IMAGE> where n is an integer from 1-5 and R is a hydrogen atom or an acyl group, R1 is an optionally modified protein radical, R2 is a methoxy group, an amino group or an α-amino acid ester which is bonded using a bond of the amide type and where the ester group contains 1-6 carbon atoms, and where R3 is a hydrogen atom or an hydroxyl group and is in all cases in the two possible configurations. These conjugates have a powerful effect when treating leukaemias, lymphosarcomas and other malignant tumours, including the so-called "solid" tumours, and when treating Hodgkin's disease.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU86157 | 1985-11-12 | ||
LU86157A LU86157A1 (en) | 1985-11-12 | 1985-11-12 | NEW PROCESS FOR THE MANUFACTURE OF VINBLASTIN CONJUGATES AND DERIVATIVES THEREOF |
EP86870042 | 1986-04-08 | ||
EP86870042A EP0222722B1 (en) | 1985-11-12 | 1986-04-08 | Conjugates of vinblastine and its derivatives, process for preparing them and pharmaceutical compositions containing these conjugates |
Publications (4)
Publication Number | Publication Date |
---|---|
DK473286D0 DK473286D0 (en) | 1986-10-03 |
DK473286A true DK473286A (en) | 1987-05-13 |
DK164107B DK164107B (en) | 1992-05-11 |
DK164107C DK164107C (en) | 1992-10-05 |
Family
ID=26106792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK473286A DK164107C (en) | 1985-11-12 | 1986-10-03 | CONJUGATES OF VINBLASTIN OR DERIVATIVES THEREOF, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
Country Status (6)
Country | Link |
---|---|
AT (1) | ATE89567T1 (en) |
AU (1) | AU577206B2 (en) |
DK (1) | DK164107C (en) |
GR (1) | GR862436B (en) |
HU (1) | HU196217B (en) |
OA (1) | OA08424A (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2508905B1 (en) * | 1981-07-01 | 1984-01-27 | Roussel Uclaf | |
DE3572177D1 (en) * | 1984-10-19 | 1989-09-14 | Nihon Mediphysics Co Ltd | IMUNOASSAY FOR ESTRIOL-3 SULFATE |
ZA873600B (en) * | 1986-05-27 | 1988-12-28 | Lilly Co Eli | Immunoglobulin conjugates |
US5094849A (en) * | 1988-08-08 | 1992-03-10 | Eli Lilly And Company | Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0124502B1 (en) * | 1983-04-29 | 1991-06-12 | OMNICHEM Société anonyme | Conjugates of vinblastine and its derivatives, process for their preparation and pharmaceutical compositions containing these conjugates |
-
1986
- 1986-04-08 AT AT86870042T patent/ATE89567T1/en not_active IP Right Cessation
- 1986-09-24 GR GR862436A patent/GR862436B/en unknown
- 1986-09-30 AU AU63401/86A patent/AU577206B2/en not_active Ceased
- 1986-10-03 DK DK473286A patent/DK164107C/en not_active IP Right Cessation
- 1986-10-06 HU HU864190A patent/HU196217B/en not_active IP Right Cessation
- 1986-10-07 OA OA58971A patent/OA08424A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU6340186A (en) | 1988-04-14 |
HUT42493A (en) | 1987-07-28 |
ATE89567T1 (en) | 1993-06-15 |
OA08424A (en) | 1988-06-30 |
DK473286D0 (en) | 1986-10-03 |
AU577206B2 (en) | 1988-09-15 |
HU196217B (en) | 1988-10-28 |
GR862436B (en) | 1986-12-23 |
DK164107B (en) | 1992-05-11 |
DK164107C (en) | 1992-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |