DK473286A - CONJUGATES OF VINBLASTIN AND DERIVATIVES THEREOF, PROCEDURES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM - Google Patents

CONJUGATES OF VINBLASTIN AND DERIVATIVES THEREOF, PROCEDURES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM Download PDF

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Publication number
DK473286A
DK473286A DK473286A DK473286A DK473286A DK 473286 A DK473286 A DK 473286A DK 473286 A DK473286 A DK 473286A DK 473286 A DK473286 A DK 473286A DK 473286 A DK473286 A DK 473286A
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DK
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Prior art keywords
conjugates
image
group
derivatives
vinblastin
Prior art date
Application number
DK473286A
Other languages
Danish (da)
Other versions
DK473286D0 (en
DK164107B (en
DK164107C (en
Inventor
Andre Benoit Lenon Trouet
Kandukuri Sivaprasade Bush Rao
Jean-Alfred Alphonse Hannart
Jean-Paul Dejonghe
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU86157A external-priority patent/LU86157A1/en
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of DK473286D0 publication Critical patent/DK473286D0/en
Publication of DK473286A publication Critical patent/DK473286A/en
Publication of DK164107B publication Critical patent/DK164107B/en
Application granted granted Critical
Publication of DK164107C publication Critical patent/DK164107C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Previously unknown conjugates of vinblastine, or derivatives thereof, have the general formula <IMAGE> where A denotes an "arm" such as <IMAGE> or <IMAGE> where n is an integer from 1-5 and R is a hydrogen atom or an acyl group, R1 is an optionally modified protein radical, R2 is a methoxy group, an amino group or an α-amino acid ester which is bonded using a bond of the amide type and where the ester group contains 1-6 carbon atoms, and where R3 is a hydrogen atom or an hydroxyl group and is in all cases in the two possible configurations. These conjugates have a powerful effect when treating leukaemias, lymphosarcomas and other malignant tumours, including the so-called "solid" tumours, and when treating Hodgkin's disease.
DK473286A 1985-11-12 1986-10-03 CONJUGATES OF VINBLASTIN OR DERIVATIVES THEREOF, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM DK164107C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU86157 1985-11-12
LU86157A LU86157A1 (en) 1985-11-12 1985-11-12 NEW PROCESS FOR THE MANUFACTURE OF VINBLASTIN CONJUGATES AND DERIVATIVES THEREOF
EP86870042 1986-04-08
EP86870042A EP0222722B1 (en) 1985-11-12 1986-04-08 Conjugates of vinblastine and its derivatives, process for preparing them and pharmaceutical compositions containing these conjugates

Publications (4)

Publication Number Publication Date
DK473286D0 DK473286D0 (en) 1986-10-03
DK473286A true DK473286A (en) 1987-05-13
DK164107B DK164107B (en) 1992-05-11
DK164107C DK164107C (en) 1992-10-05

Family

ID=26106792

Family Applications (1)

Application Number Title Priority Date Filing Date
DK473286A DK164107C (en) 1985-11-12 1986-10-03 CONJUGATES OF VINBLASTIN OR DERIVATIVES THEREOF, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Country Status (6)

Country Link
AT (1) ATE89567T1 (en)
AU (1) AU577206B2 (en)
DK (1) DK164107C (en)
GR (1) GR862436B (en)
HU (1) HU196217B (en)
OA (1) OA08424A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508905B1 (en) * 1981-07-01 1984-01-27 Roussel Uclaf
DE3572177D1 (en) * 1984-10-19 1989-09-14 Nihon Mediphysics Co Ltd IMUNOASSAY FOR ESTRIOL-3 SULFATE
ZA873600B (en) * 1986-05-27 1988-12-28 Lilly Co Eli Immunoglobulin conjugates
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124502B1 (en) * 1983-04-29 1991-06-12 OMNICHEM Société anonyme Conjugates of vinblastine and its derivatives, process for their preparation and pharmaceutical compositions containing these conjugates

Also Published As

Publication number Publication date
AU6340186A (en) 1988-04-14
HUT42493A (en) 1987-07-28
ATE89567T1 (en) 1993-06-15
OA08424A (en) 1988-06-30
DK473286D0 (en) 1986-10-03
AU577206B2 (en) 1988-09-15
HU196217B (en) 1988-10-28
GR862436B (en) 1986-12-23
DK164107B (en) 1992-05-11
DK164107C (en) 1992-10-05

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