HUT42493A - Process for producing new conjugates and derivatives of vinblastine and pharmaceutical compositions containing them - Google Patents

Process for producing new conjugates and derivatives of vinblastine and pharmaceutical compositions containing them

Info

Publication number
HUT42493A
HUT42493A HU864190A HU419086A HUT42493A HU T42493 A HUT42493 A HU T42493A HU 864190 A HU864190 A HU 864190A HU 419086 A HU419086 A HU 419086A HU T42493 A HUT42493 A HU T42493A
Authority
HU
Hungary
Prior art keywords
vinblastine
derivatives
image
group
conjugates
Prior art date
Application number
HU864190A
Other languages
Hungarian (hu)
Other versions
HU196217B (en
Inventor
Andre B Trouet
Kandukuri S Rao
Jean-Alfred A Hannart
Jean-Paul Dejondhe
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU86157A external-priority patent/LU86157A1/en
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of HUT42493A publication Critical patent/HUT42493A/en
Publication of HU196217B publication Critical patent/HU196217B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Previously unknown conjugates of vinblastine, or derivatives thereof, have the general formula <IMAGE> where A denotes an "arm" such as <IMAGE> or <IMAGE> where n is an integer from 1-5 and R is a hydrogen atom or an acyl group, R1 is an optionally modified protein radical, R2 is a methoxy group, an amino group or an α-amino acid ester which is bonded using a bond of the amide type and where the ester group contains 1-6 carbon atoms, and where R3 is a hydrogen atom or an hydroxyl group and is in all cases in the two possible configurations. These conjugates have a powerful effect when treating leukaemias, lymphosarcomas and other malignant tumours, including the so-called "solid" tumours, and when treating Hodgkin's disease.
HU864190A 1985-11-12 1986-10-06 Process for production of new vinblastin-ensime-conjugates and their derivatives and medical compounds containing such substances HU196217B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU86157A LU86157A1 (en) 1985-11-12 1985-11-12 NEW PROCESS FOR THE MANUFACTURE OF VINBLASTIN CONJUGATES AND DERIVATIVES THEREOF
EP86870042A EP0222722B1 (en) 1985-11-12 1986-04-08 Conjugates of vinblastine and its derivatives, process for preparing them and pharmaceutical compositions containing these conjugates

Publications (2)

Publication Number Publication Date
HUT42493A true HUT42493A (en) 1987-07-28
HU196217B HU196217B (en) 1988-10-28

Family

ID=26106792

Family Applications (1)

Application Number Title Priority Date Filing Date
HU864190A HU196217B (en) 1985-11-12 1986-10-06 Process for production of new vinblastin-ensime-conjugates and their derivatives and medical compounds containing such substances

Country Status (6)

Country Link
AT (1) ATE89567T1 (en)
AU (1) AU577206B2 (en)
DK (1) DK164107C (en)
GR (1) GR862436B (en)
HU (1) HU196217B (en)
OA (1) OA08424A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508905B1 (en) * 1981-07-01 1984-01-27 Roussel Uclaf
CA1285866C (en) * 1984-10-19 1991-07-09 Akiko Kubodera Immunoassay for estriol-3-sulfate
ZA873600B (en) * 1986-05-27 1988-12-28 Lilly Co Eli Immunoglobulin conjugates
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (en) * 1983-04-29 1984-12-12 Omnichem Sa

Also Published As

Publication number Publication date
GR862436B (en) 1986-12-23
AU6340186A (en) 1988-04-14
DK164107C (en) 1992-10-05
HU196217B (en) 1988-10-28
DK473286A (en) 1987-05-13
OA08424A (en) 1988-06-30
ATE89567T1 (en) 1993-06-15
DK164107B (en) 1992-05-11
DK473286D0 (en) 1986-10-03
AU577206B2 (en) 1988-09-15

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee