ATE87621T1 - Antikrebs-chinazolinon-derivate. - Google Patents

Antikrebs-chinazolinon-derivate.

Info

Publication number
ATE87621T1
ATE87621T1 AT86304148T AT86304148T ATE87621T1 AT E87621 T1 ATE87621 T1 AT E87621T1 AT 86304148 T AT86304148 T AT 86304148T AT 86304148 T AT86304148 T AT 86304148T AT E87621 T1 ATE87621 T1 AT E87621T1
Authority
AT
Austria
Prior art keywords
group
heteroatom
cancer
quinazolinone derivatives
halogeno
Prior art date
Application number
AT86304148T
Other languages
English (en)
Inventor
Terence Richard Jones
Ann Lesley Jackman
David Richard Newell
Original Assignee
British Tech Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Tech Group filed Critical British Tech Group
Application granted granted Critical
Publication of ATE87621T1 publication Critical patent/ATE87621T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT86304148T 1985-05-31 1986-05-30 Antikrebs-chinazolinon-derivate. ATE87621T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513754A GB8513754D0 (en) 1985-05-31 1985-05-31 Anti-cancer quinazoline derivatives
EP86304148A EP0204529B1 (de) 1985-05-31 1986-05-30 Antikrebs-Chinazolinon-Derivate

Publications (1)

Publication Number Publication Date
ATE87621T1 true ATE87621T1 (de) 1993-04-15

Family

ID=10579966

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86304148T ATE87621T1 (de) 1985-05-31 1986-05-30 Antikrebs-chinazolinon-derivate.

Country Status (17)

Country Link
US (1) US5236927A (de)
EP (1) EP0204529B1 (de)
JP (1) JPS61282368A (de)
AT (1) ATE87621T1 (de)
AU (1) AU592271B2 (de)
DE (1) DE3688150T2 (de)
DK (1) DK255786A (de)
ES (1) ES8800911A1 (de)
FI (1) FI862303A (de)
GB (2) GB8513754D0 (de)
GR (1) GR861418B (de)
HU (1) HUT45512A (de)
IL (1) IL78910A0 (de)
NO (1) NO862170L (de)
NZ (1) NZ216363A (de)
PT (1) PT82682B (de)
ZA (1) ZA864051B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4857530A (en) * 1987-11-03 1989-08-15 Warner-Lambert Company Substituted quinazolinones as anticancer agents
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
EP0365763A1 (de) * 1988-09-30 1990-05-02 Agouron Pharmaceuticals, Inc. Zyklische Verbindungen als Antiproleferahne
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
US7262058B2 (en) * 2001-03-09 2007-08-28 Nonda Katopodis Method for determining lipid associated sialoprotein in body fluids
RU2005115106A (ru) * 2002-10-18 2005-10-10 Конинклейке Филипс Электроникс Н.В. (Nl) Способ, система, устройство, сигнал и программный продукт для защиты метаданных в tv-anytime
CA2502302A1 (en) * 2002-11-04 2004-05-21 Nps Pharmaceuticals, Inc. Quinazolinone compounds as calcilytics
CA2615380A1 (en) * 2005-07-15 2007-01-25 Schering Corporation Quinazoline derivatives useful in cancer treatment
CA2615373A1 (en) * 2005-07-15 2007-01-25 Schering Corporation Quinazoline derivatives useful in cancer treatment
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
TW201716385A (zh) 2007-10-26 2017-05-16 加州大學董事會 二芳基乙內醯脲類化合物
NZ597107A (en) 2009-06-25 2013-12-20 Alkermes Pharma Ireland Ltd Heterocyclic compounds for the treatment of neurological and psychological disorders
JP6076740B2 (ja) * 2010-01-07 2017-02-08 アルカーメス ファーマ アイルランド リミテッド 第四級アンモニウム塩プロドラッグ
NZ604423A (en) 2010-06-24 2015-01-30 Alkermes Pharma Ireland Ltd Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
ES2972387T3 (es) 2011-03-18 2024-06-12 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de sorbitán
JP6219918B2 (ja) 2012-03-19 2017-10-25 アルカームス ファーマ アイルランド リミテッド グリセロールエステルを含む医薬組成物
NZ630643A (en) 2012-03-19 2017-08-25 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising fatty acid esters
EP2827866B1 (de) 2012-03-19 2023-05-03 Alkermes Pharma Ireland Limited Pharmazeutische zusammensetzungen mit benzylalkohol
ES2792149T3 (es) 2012-09-19 2020-11-10 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que tienen estabilidad de almacenamiento mejorada
AU2015231278B2 (en) 2014-03-20 2020-01-23 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
EP3761983A1 (de) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Dosierstrategie für aripiprazol
WO2024028999A1 (ja) * 2022-08-03 2024-02-08 Ils株式会社 Ｎ－［４－メチルアミノベンゾイル］－ｌ－グルタミン酸ジエチルエステルの製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1021196A (en) * 1964-02-20 1966-03-02 Parke Davis & Co Novel amino acids and means for producing the same
US3471498A (en) * 1967-08-11 1969-10-07 Parke Davis & Co Certain n-p-((2,4-diamino-6-quinazolinyl)-methyl)benzoylamino acids
EP0031237B1 (de) 1979-12-19 1984-10-17 National Research Development Corporation Chinazolinderivate, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung als Anti-Krebs-Mittel
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents

Also Published As

Publication number Publication date
EP0204529B1 (de) 1993-03-31
AU592271B2 (en) 1990-01-04
GB8613184D0 (en) 1986-07-02
GB8513754D0 (en) 1985-07-03
FI862303A (fi) 1986-12-01
DK255786D0 (da) 1986-05-30
EP0204529A2 (de) 1986-12-10
DE3688150D1 (de) 1993-05-06
PT82682A (en) 1986-06-01
EP0204529A3 (en) 1987-11-19
IL78910A0 (en) 1986-09-30
PT82682B (pt) 1988-03-03
AU5822086A (en) 1986-12-04
NZ216363A (en) 1989-07-27
GB2175903B (en) 1988-10-12
DK255786A (da) 1986-12-01
HUT45512A (en) 1988-07-28
ZA864051B (en) 1987-01-28
NO862170L (no) 1986-12-01
JPS61282368A (ja) 1986-12-12
ES555548A0 (es) 1987-12-01
FI862303A0 (fi) 1986-05-30
ES8800911A1 (es) 1987-12-01
GR861418B (en) 1986-09-26
DE3688150T2 (de) 1993-07-29
US5236927A (en) 1993-08-17
GB2175903A (en) 1986-12-10

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties