ATE87331T1 - Hefe-promotor. - Google Patents

Hefe-promotor.

Info

Publication number
ATE87331T1
ATE87331T1 AT87307668T AT87307668T ATE87331T1 AT E87331 T1 ATE87331 T1 AT E87331T1 AT 87307668 T AT87307668 T AT 87307668T AT 87307668 T AT87307668 T AT 87307668T AT E87331 T1 ATE87331 T1 AT E87331T1
Authority
AT
Austria
Prior art keywords
activation sequence
upstream activation
pgk
gal10
hybrid
Prior art date
Application number
AT87307668T
Other languages
English (en)
Inventor
Susan Mary Kingsman
Mark Julian Wilson
Diane Joan Cousens
Edward Hinchliffe
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Application granted granted Critical
Publication of ATE87331T1 publication Critical patent/ATE87331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87307668T 1986-08-29 1987-08-28 Hefe-promotor. ATE87331T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868620926A GB8620926D0 (en) 1986-08-29 1986-08-29 Yeast promoter
EP87307668A EP0258067B1 (de) 1986-08-29 1987-08-28 Hefe-Promotor

Publications (1)

Publication Number Publication Date
ATE87331T1 true ATE87331T1 (de) 1993-04-15

Family

ID=10603398

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87307668T ATE87331T1 (de) 1986-08-29 1987-08-28 Hefe-promotor.

Country Status (13)

Country Link
US (1) US5739007A (de)
EP (1) EP0258067B1 (de)
JP (1) JP2641457B2 (de)
AT (1) ATE87331T1 (de)
AU (1) AU604257B2 (de)
CA (1) CA1291428C (de)
DE (1) DE3784986T2 (de)
DK (1) DK173186B1 (de)
ES (1) ES2054682T3 (de)
FI (1) FI96620C (de)
GB (2) GB8620926D0 (de)
IE (1) IE59986B1 (de)
ZA (1) ZA876447B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003008A1 (en) * 1985-11-13 1987-05-21 International Genetic Engineering, Inc. Shortened phosphoglycerate kinase promoter
GB8725529D0 (en) * 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
IL89992A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human serum albumin in methylotrophic yeasts
FR2634495B1 (fr) * 1988-07-01 1990-10-26 Chambon Pierre Procede de preparation d'une proteine par des levures utilisant un systeme inductible, vecteurs et souches transformees correspondantes
FR2649991B2 (fr) * 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9712370D0 (en) 1997-06-14 1997-08-13 Aepact Ltd Therapeutic systems
ES2529300T3 (es) 2000-04-12 2015-02-18 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) * 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
WO2003059934A2 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
ES2425738T3 (es) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
WO2003066085A1 (en) 2002-02-07 2003-08-14 Delta Biotechnology Limited Albumin-fused anti-angiogenesis peptides
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
JP2007517506A (ja) 2004-01-05 2007-07-05 イーエムディー・レキシゲン・リサーチ・センター・コーポレーション 標的化用化合物
EP2330200B1 (de) 2004-12-23 2017-04-05 Albumedix A/S Genexpressionstechnik
ATE482265T1 (de) * 2005-06-14 2010-10-15 Merck Sharp & Dohme Kontrollregion eines synthetischen gens
CA2658654A1 (en) 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
WO2008019368A2 (en) 2006-08-07 2008-02-14 Teva Biopharmaceuticals Usa, Inc. Albumin-insulin fusion proteins
ES2566385T3 (es) 2007-02-12 2016-04-12 Csl Behring Gmbh Aplicación terapéutica de inhibidores de la proteasa de serina de tipo Kazal
EP2594583A1 (de) 2007-08-08 2013-05-22 Novozymes Biopharma DK A/S Transferrinvarianten und Konjugate
EP2262892A4 (de) * 2008-04-08 2011-09-21 Amyris Biotechnologies Inc Expression heterologer sequenzen
JP2012516878A (ja) 2009-02-06 2012-07-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 精製プロセス
KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
EP2371857A1 (de) 2010-04-01 2011-10-05 CSL Behring GmbH Faktor-XII-Inhibitoren zur Behandlung von interstitieller Pneumonie
CA2828811C (en) 2011-03-03 2021-09-21 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs
CA2878640C (en) 2012-07-13 2023-10-24 Zymeworks Inc. Multivalent heteromultimer scaffold design and constructs
EP2994164B1 (de) 2013-05-08 2020-08-05 Zymeworks Inc. Bispezifische her2- und her3-antigenbindende konstrukte
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
US20200270335A1 (en) 2015-12-23 2020-08-27 Biogen Ma Inc. Dkk2 cysteine rich domain 2 containing proteins and uses thereof
AU2019371814A1 (en) 2018-10-29 2021-06-17 Biogen Ma Inc. Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport
CN113462686B (zh) * 2020-03-30 2023-06-02 中国科学院深圳先进技术研究院 制备具有梯度活性的半乳糖诱导合成启动子的方法、及其制备的启动子、应用
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN116744984A (zh) 2020-12-28 2023-09-12 达沃有限公司 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615974A (en) * 1981-08-25 1986-10-07 Celltech Limited Yeast expression vectors
US4803164A (en) * 1981-08-31 1989-02-07 Genentech, Inc. Preparation of hepatitis b surface antigen in yeast
US4876197A (en) * 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
GB8314961D0 (en) * 1983-05-31 1983-07-06 Kingsman A J Dna sequence
ATE102250T1 (de) * 1984-05-11 1994-03-15 Chiron Corp Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion.
JP2615027B2 (ja) * 1985-04-08 1997-05-28 アムジェン インコーポレイテッド 外来遺伝子の転写を制御するための方法及びハイブリッドプロモーター
GB8510219D0 (en) * 1985-04-22 1985-05-30 Bass Plc Isolation of fermentation products
GB8521496D0 (en) * 1985-08-29 1985-10-02 Ciba Geigy Ag Repressible yeast promoters
MY101203A (en) * 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.

Also Published As

Publication number Publication date
GB8720396D0 (en) 1987-10-07
JP2641457B2 (ja) 1997-08-13
IE872308L (en) 1988-02-29
CA1291428C (en) 1991-10-29
DE3784986T2 (de) 1993-07-01
IE59986B1 (en) 1994-05-04
AU7765787A (en) 1988-05-19
FI873729A0 (fi) 1987-08-27
DK447287A (da) 1988-05-20
EP0258067A3 (en) 1989-05-10
FI96620B (fi) 1996-04-15
US5739007A (en) 1998-04-14
DE3784986D1 (en) 1993-04-29
ES2054682T3 (es) 1994-08-16
FI873729L (fi) 1988-03-01
EP0258067B1 (de) 1993-03-24
AU604257B2 (en) 1990-12-13
DK447287D0 (da) 1987-08-27
JPS63112988A (ja) 1988-05-18
ZA876447B (en) 1988-05-25
GB2196635B (en) 1990-12-05
GB8620926D0 (en) 1986-10-08
DK173186B1 (da) 2000-03-06
GB2196635A (en) 1988-05-05
EP0258067A2 (de) 1988-03-02
FI96620C (fi) 1996-07-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time