ATE818T1 - N-substituierte 2-cyanaziridine, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel, entsprechend substituierte aziridin-2-carbonsaeureamide und deren herstellung. - Google Patents
N-substituierte 2-cyanaziridine, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel, entsprechend substituierte aziridin-2-carbonsaeureamide und deren herstellung.Info
- Publication number
- ATE818T1 ATE818T1 AT80100792T AT80100792T ATE818T1 AT E818 T1 ATE818 T1 AT E818T1 AT 80100792 T AT80100792 T AT 80100792T AT 80100792 T AT80100792 T AT 80100792T AT E818 T1 ATE818 T1 AT E818T1
- Authority
- AT
- Austria
- Prior art keywords
- manufacture
- substituted
- cyanaziridines
- substances
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19792906603 DE2906603A1 (de) | 1979-02-21 | 1979-02-21 | N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel |
EP80100792A EP0014976B1 (de) | 1979-02-21 | 1980-02-16 | N-substituierte 2-Cyanaziridine, Verfahren zu deren Herstellung sowie diese Substanzen enthaltende Arzneimittel, entsprechend substituierte Aziridin-2-carbonsäureamide und deren Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE818T1 true ATE818T1 (de) | 1982-04-15 |
Family
ID=6063481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT80100792T ATE818T1 (de) | 1979-02-21 | 1980-02-16 | N-substituierte 2-cyanaziridine, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel, entsprechend substituierte aziridin-2-carbonsaeureamide und deren herstellung. |
Country Status (19)
Country | Link |
---|---|
US (2) | US4397848A (cs) |
EP (1) | EP0014976B1 (cs) |
JP (1) | JPS55113760A (cs) |
AR (1) | AR223863A1 (cs) |
AT (1) | ATE818T1 (cs) |
AU (1) | AU529982B2 (cs) |
CA (1) | CA1148962A (cs) |
CS (1) | CS208798B2 (cs) |
DD (1) | DD148772A5 (cs) |
DE (2) | DE2906603A1 (cs) |
ES (1) | ES488656A1 (cs) |
FI (1) | FI70702C (cs) |
HU (1) | HU182801B (cs) |
IE (1) | IE49267B1 (cs) |
IL (1) | IL59425A (cs) |
PL (1) | PL129707B1 (cs) |
PT (1) | PT70847A (cs) |
SU (1) | SU1181541A3 (cs) |
ZA (1) | ZA80902B (cs) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925835A (en) * | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
JPH07301287A (ja) * | 1995-03-23 | 1995-11-14 | Sumitomo Heavy Ind Ltd | 制御装置に用いられる内接噛合遊星歯車機構 |
ES2210774T3 (es) * | 1997-06-27 | 2004-07-01 | Amplimed, Inc. | Nuevas cianoaziridinas para el tratamiento del cancer. |
US20030129222A1 (en) * | 2000-11-21 | 2003-07-10 | Gabriel Lopez-Berestein | Liposomal imexon |
AU2002216672A1 (en) * | 2000-11-21 | 2002-06-03 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Composition comprising an imexon or derivatives thereof and lipids |
ATE374602T1 (de) * | 2001-12-21 | 2007-10-15 | Supernus Pharmaceuticals Inc | Orale kapselformulierung mit verbesserter physikalischer stabilität |
US20040005339A1 (en) * | 2002-06-28 | 2004-01-08 | Shojaei Amir H. | Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability |
GEP20084540B (en) | 2003-01-14 | 2008-11-25 | Arena Pharm Inc | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
CN1751038A (zh) * | 2003-02-24 | 2006-03-22 | 艾尼纳制药公司 | 作为葡萄糖代谢调节剂的经取代芳基和杂芳基衍生物及葡萄糖代谢失调的预防和治疗 |
AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
PE20060530A1 (es) * | 2004-06-04 | 2006-06-28 | Arena Pharm Inc | Aril y heteroaril derivados sustituidos como moduladores del metabolismo de la glucosa |
MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
BRPI0616245A2 (pt) * | 2005-09-16 | 2011-06-14 | Arena Pharm Inc | modulador de metabolismo, seus usos, composiÇço farmaceutica compreendendo o mesmo, bem como mÉtodo para produÇço da referida composiÇço |
TW200811140A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
TW200811147A (en) * | 2006-07-06 | 2008-03-01 | Arena Pharm Inc | Modulators of metabolism and the treatment of disorders related thereto |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
KR102603199B1 (ko) | 2015-06-22 | 2023-11-16 | 아레나 파마슈티칼스, 인크. | S1p1 수용체-관련 장애에서의 사용을 위한 (r)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[b]인돌-3-일)아세트산 (화합물 1)의 결정성 l-아르기닌 염 |
MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
CN113816887A (zh) * | 2021-08-31 | 2021-12-21 | 华中科技大学 | 一种氮杂环丙烷类化合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2644820A1 (de) * | 1976-10-05 | 1978-04-06 | Boehringer Mannheim Gmbh | Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben |
DE2731264A1 (de) | 1977-07-11 | 1979-02-01 | Boehringer Mannheim Gmbh | Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen |
-
1979
- 1979-02-21 DE DE19792906603 patent/DE2906603A1/de not_active Withdrawn
-
1980
- 1980-02-15 ES ES488656A patent/ES488656A1/es not_active Expired
- 1980-02-16 DE DE8080100792T patent/DE3060268D1/de not_active Expired
- 1980-02-16 AT AT80100792T patent/ATE818T1/de not_active IP Right Cessation
- 1980-02-16 EP EP80100792A patent/EP0014976B1/de not_active Expired
- 1980-02-18 SU SU802882348A patent/SU1181541A3/ru active
- 1980-02-18 ZA ZA00800902A patent/ZA80902B/xx unknown
- 1980-02-18 AU AU55649/80A patent/AU529982B2/en not_active Ceased
- 1980-02-18 CA CA000345886A patent/CA1148962A/en not_active Expired
- 1980-02-18 PL PL1980222088A patent/PL129707B1/pl unknown
- 1980-02-19 HU HU80383A patent/HU182801B/hu not_active IP Right Cessation
- 1980-02-19 DD DD80219137A patent/DD148772A5/de not_active IP Right Cessation
- 1980-02-19 IL IL59425A patent/IL59425A/xx unknown
- 1980-02-19 CS CS801134A patent/CS208798B2/cs unknown
- 1980-02-20 PT PT70847A patent/PT70847A/pt unknown
- 1980-02-20 IE IE327/80A patent/IE49267B1/en unknown
- 1980-02-20 FI FI800510A patent/FI70702C/fi not_active IP Right Cessation
- 1980-02-21 JP JP1977580A patent/JPS55113760A/ja active Granted
-
1981
- 1981-02-15 AR AR279976A patent/AR223863A1/es active
- 1981-02-20 US US06/236,375 patent/US4397848A/en not_active Expired - Fee Related
-
1983
- 1983-05-17 US US06/495,548 patent/US4517183A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA1148962A (en) | 1983-06-28 |
FI800510A (fi) | 1980-08-22 |
DE2906603A1 (de) | 1980-09-04 |
EP0014976B1 (de) | 1982-04-07 |
EP0014976A1 (de) | 1980-09-03 |
IE800327L (en) | 1980-08-21 |
US4517183A (en) | 1985-05-14 |
AU5564980A (en) | 1980-08-28 |
AU529982B2 (en) | 1983-06-30 |
HU182801B (en) | 1984-03-28 |
PT70847A (de) | 1980-03-01 |
JPH0150700B2 (cs) | 1989-10-31 |
FI70702B (fi) | 1986-06-26 |
AR223863A1 (es) | 1981-09-30 |
IE49267B1 (en) | 1985-09-04 |
PL222088A1 (cs) | 1980-12-01 |
US4397848A (en) | 1983-08-09 |
CS208798B2 (en) | 1981-09-15 |
ZA80902B (en) | 1981-03-25 |
ES488656A1 (es) | 1980-09-16 |
DD148772A5 (de) | 1981-06-10 |
FI70702C (fi) | 1986-10-06 |
SU1181541A3 (ru) | 1985-09-23 |
PL129707B1 (en) | 1984-06-30 |
IL59425A0 (en) | 1980-05-30 |
DE3060268D1 (en) | 1982-05-19 |
JPS55113760A (en) | 1980-09-02 |
IL59425A (en) | 1984-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |