ATE74752T1 - Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes. - Google Patents

Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes.

Info

Publication number
ATE74752T1
ATE74752T1 AT87305625T AT87305625T ATE74752T1 AT E74752 T1 ATE74752 T1 AT E74752T1 AT 87305625 T AT87305625 T AT 87305625T AT 87305625 T AT87305625 T AT 87305625T AT E74752 T1 ATE74752 T1 AT E74752T1
Authority
AT
Austria
Prior art keywords
fluids
pharmaceutical compound
body fluids
drug release
microparticles
Prior art date
Application number
AT87305625T
Other languages
German (de)
English (en)
Inventor
John Weldon Shell
Original Assignee
Iolab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iolab Inc filed Critical Iolab Inc
Application granted granted Critical
Publication of ATE74752T1 publication Critical patent/ATE74752T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87305625T 1986-06-25 1987-06-24 Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes. ATE74752T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87827286A 1986-06-25 1986-06-25
EP87305625A EP0251680B1 (en) 1986-06-25 1987-06-24 Controlled release bioerodible drug delivery system

Publications (1)

Publication Number Publication Date
ATE74752T1 true ATE74752T1 (de) 1992-05-15

Family

ID=25371703

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87305625T ATE74752T1 (de) 1986-06-25 1987-06-24 Biologisch erodierbares system mit gesteuerter freisetzung des arzneiwirkstoffes.

Country Status (8)

Country Link
EP (1) EP0251680B1 (forum.php)
JP (1) JPS6322516A (forum.php)
AT (1) ATE74752T1 (forum.php)
AU (1) AU606872B2 (forum.php)
CA (1) CA1311686C (forum.php)
DE (1) DE3778223D1 (forum.php)
ES (1) ES2037082T3 (forum.php)
GR (1) GR3004710T3 (forum.php)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853224A (en) * 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
ES2057021T3 (es) * 1988-06-07 1994-10-16 Abbott Lab Un metodo de manufactura de una dosificacion farmaceutica solida en forma de triturado en tableta.
US5082667A (en) * 1988-06-07 1992-01-21 Abbott Laboratories Solid pharmaceutical dosage in tablet triturate form and method of producing same
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
GB8917217D0 (en) * 1989-07-27 1989-09-13 Smith & Nephew Ophthalmic compositions
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
JP3011752B2 (ja) * 1990-10-23 2000-02-21 フロイント産業株式会社 徐放性製剤およびその製造方法
FR2673843B1 (fr) * 1991-03-14 1995-01-13 Centre Nat Rech Scient Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
US5912015A (en) * 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
EP0762874A4 (en) * 1992-12-30 1997-08-06 Clover Cons Ltd BIOLOGICALLY ACTIVE SUBSTANCE PACKAGING SYSTEMS IN RECOVERABLE, BIOCOMPATIBLE AND CYTOPROTECTOR MACROCAPSULES
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
JP2000507912A (ja) * 1995-08-31 2000-06-27 アルカームズ コントロールド セラピューティックス，インコーポレイテッド 作用剤の徐放性組成物
DE19756314C2 (de) * 1997-12-12 2000-06-29 Roland Bodmeier Zubereitung mit verlängerter Verweildauer am Applikationsort
US6264971B1 (en) 1999-11-04 2001-07-24 Btg International Limited Ocular insert
DE10133870A1 (de) * 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
JP2005525299A (ja) * 2001-09-14 2005-08-25 スコラー インコーポレイテッド アミノ酸調節性の長期放出投薬形態
DE10246900A1 (de) 2002-10-08 2004-04-22 Horstmann, Michael, Dr. Am Auge applizierbare Vorrichtung zur sicheren Dosierung systemischer und tropischer Medikation
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8673341B2 (en) 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
DK1817003T3 (en) * 2004-10-29 2018-05-22 Univ California Porous silicon microparticles for drug delivery to the eye
JP2006257080A (ja) * 2005-02-18 2006-09-28 Santen Pharmaceut Co Ltd ステロイド化合物の副作用軽減または回避方法
WO2007106557A2 (en) 2006-03-14 2007-09-20 University Of Southern California Mems device for delivery of therapeutic agents
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US7638344B2 (en) * 2006-06-28 2009-12-29 Surmodics, Inc. Active agent eluting matrices with particulates
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
US20080292680A1 (en) * 2007-05-14 2008-11-27 Sustained Nano Systems Llc Hypercompressed polymer particles for controlled release ophthalmic medications
JP5542691B2 (ja) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア 治療薬を送達するための装置および方法
DK2240220T3 (en) 2008-01-03 2016-08-01 Univ Southern California Implantable devices for drug AND APPARATUS FOR refilling DEVICES
MX2010012212A (es) 2008-05-08 2011-09-27 Minipumps Llc Dispositivos implantables para suministro de fármacos, y áparato y métodos para llenar los dispositivos.
CN102202708B (zh) 2008-05-08 2015-01-21 迷你泵有限责任公司 药物输送泵及其制造方法
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
JP5719767B2 (ja) 2008-05-08 2015-05-20 ミニパンプス， エルエルシー 埋込型ポンプおよびそのためのカニューレ
WO2010066203A1 (en) * 2008-12-10 2010-06-17 Anhui Zhongren Technology Co., Ltd. Controlled releasing composition
USD629503S1 (en) 2009-05-08 2010-12-21 Sean Caffey Implantable drug-delivery pump
EP4108216A1 (en) * 2009-06-03 2022-12-28 Forsight Vision5, Inc. Anterior segment drug delivery
CN102576385B (zh) 2009-08-18 2016-02-24 迷你泵有限责任公司 具有自适应控制的电解药物输送泵
US8469934B2 (en) 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
JP2012025708A (ja) * 2010-07-27 2012-02-09 Sepa Sigma Inc 膜透過機構を異にする複数の徐放機構を利用した徐放化局所投与剤
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
MX2013008993A (es) 2013-08-02 2014-03-24 Raam De Sahuayo S A De C V Lab Sistema de liberacion modificada en tres fases de un antiinflamatorio no esteroide.
HUE050902T2 (hu) 2013-10-31 2021-01-28 Allergan Inc Prosztamidot tartalmazó intraokuláris implantátumok és azok alkalmazási módszerei
EP3302382A4 (en) * 2015-05-29 2019-02-20 Allergan, Inc. IMPLANT FOR THE TREATMENT OF OCULAR DISEASE
EP3108874A1 (en) * 2015-06-26 2016-12-28 TRB Chemedica AG Ophthalmologic pharmaceutical composition
EP3654950A4 (en) * 2017-07-17 2021-04-21 Wolfcreek Biotech Pte Ltd MICROPARTICLE FORMULATIONS FOR THE DELIVERY OF ACTIVE INGREDIENTS
CN115554460A (zh) * 2022-09-26 2023-01-03 山东万容生物科技有限公司 一种多功能湿性敷料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788575A (fr) * 1971-09-09 1973-01-02 Alza Corp Dispositif oculaire pour l'administration d'un
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
US4179497A (en) * 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
IE50901B1 (en) * 1980-03-04 1986-08-06 Merck & Co Inc Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation

Also Published As

Publication number Publication date
CA1311686C (en) 1992-12-22
EP0251680A2 (en) 1988-01-07
ES2037082T3 (es) 1993-06-16
AU606872B2 (en) 1991-02-21
EP0251680A3 (en) 1988-02-24
JPS6322516A (ja) 1988-01-30
GR3004710T3 (forum.php) 1993-04-28
AU7465087A (en) 1988-01-07
DE3778223D1 (de) 1992-05-21
EP0251680B1 (en) 1992-04-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee