ATE71937T1 - Verfahren zur herstellung von octahydroindolderivaten und ihre zwischenprodukte. - Google Patents
Verfahren zur herstellung von octahydroindolderivaten und ihre zwischenprodukte.Info
- Publication number
- ATE71937T1 ATE71937T1 AT87402354T AT87402354T ATE71937T1 AT E71937 T1 ATE71937 T1 AT E71937T1 AT 87402354 T AT87402354 T AT 87402354T AT 87402354 T AT87402354 T AT 87402354T AT E71937 T1 ATE71937 T1 AT E71937T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- image
- acid
- carbon atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 239000005711 Benzoic acid Substances 0.000 abstract 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 2
- 235000010233 benzoic acid Nutrition 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
- C07C61/09—Completely hydrogenated benzenedicarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Graft Or Block Polymers (AREA)
- Lubricants (AREA)
- Liquid Developers In Electrophotography (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8614650A FR2605630B1 (fr) | 1986-10-22 | 1986-10-22 | Procede de preparation de derives de l'octahydroindole et intermediaires de preparation |
| EP87402354A EP0267098B1 (fr) | 1986-10-22 | 1987-10-21 | Procédé de préparation de dérivés de l'octahydroindole et intermédiaires de préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE71937T1 true ATE71937T1 (de) | 1992-02-15 |
Family
ID=9340061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87402354T ATE71937T1 (de) | 1986-10-22 | 1987-10-21 | Verfahren zur herstellung von octahydroindolderivaten und ihre zwischenprodukte. |
Country Status (14)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19801646A1 (de) * | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
| DE19900205A1 (de) * | 1999-01-07 | 2000-07-13 | Basf Ag | Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür |
| JP2005519098A (ja) * | 2002-03-01 | 2005-06-30 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 変形性関節症の治療方法 |
| JP4884758B2 (ja) * | 2005-12-12 | 2012-02-29 | 株式会社フジキン | エントランス絞り溝付微小流量制御装置の設計方法、 |
| US7570523B2 (en) * | 2006-07-31 | 2009-08-04 | Sandisk 3D Llc | Method for using two data busses for memory array block selection |
| JP2012533563A (ja) | 2009-07-16 | 2012-12-27 | アボット ラボラトリーズ | トランドラプリル用の中間体である（２Ｓ，３ａＲ，７ａＳ）−オクタヒドロ−１Ｈ−インドールカルボン酸の合成法 |
| EP2576803B1 (en) | 2010-05-24 | 2019-07-10 | BGP Products Operations GmbH | PREPARATION OF (3aS,7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYZED BIOLOGICAL RESOLUTION OF DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE |
| AU2014200205B2 (en) * | 2010-05-24 | 2016-03-31 | Bgp Products Operations Gmbh | Preparation of (3aS,7aR)-hexahydroisobenzofuran-1(3H)-one by catalyzed biological resolution of dimethyl cyclohexane-1,2-dicarboxylate |
| CN103360299B (zh) * | 2012-04-06 | 2017-03-01 | 武汉启瑞药业有限公司 | 群多普利中间体的异构体的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2315661A (en) * | 1939-05-27 | 1943-04-06 | Winthrop Chem Co Inc | Manufacture of nitrile compounds |
| DE1695609A1 (de) * | 1967-01-12 | 1972-02-24 | Ruetgerswerke Ag | Verfahren zur Herstellung von Indolyl-3-acetonitril |
| US4156016A (en) * | 1977-03-03 | 1979-05-22 | Hoffmann-La Roche Inc. | Indole compounds and process for their preparation |
| CA1125783A (en) * | 1978-03-27 | 1982-06-15 | Michael E. Condon | Thioalkanoylalkanoic acid compounds |
| IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
| GR78413B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1981-12-29 | 1984-09-27 | Hoechst Ag | |
| US4490386A (en) * | 1982-09-23 | 1984-12-25 | Warner-Lambert Company | Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof |
-
1986
- 1986-10-22 FR FR8614650A patent/FR2605630B1/fr not_active Expired
-
1987
- 1987-10-05 IE IE265287A patent/IE60280B1/en not_active IP Right Cessation
- 1987-10-20 JP JP62262951A patent/JPH082873B2/ja not_active Expired - Lifetime
- 1987-10-21 US US07/111,982 patent/US4879392A/en not_active Expired - Lifetime
- 1987-10-21 DK DK550587A patent/DK170095B1/da not_active IP Right Cessation
- 1987-10-21 CA CA000549874A patent/CA1292001C/fr not_active Expired - Lifetime
- 1987-10-21 ES ES198787402354T patent/ES2038684T3/es not_active Expired - Lifetime
- 1987-10-21 DE DE8787402354T patent/DE3776273D1/de not_active Expired - Lifetime
- 1987-10-21 AT AT87402354T patent/ATE71937T1/de not_active IP Right Cessation
- 1987-10-21 PT PT85964A patent/PT85964B/pt unknown
- 1987-10-21 EP EP87402354A patent/EP0267098B1/fr not_active Expired - Lifetime
- 1987-10-21 FI FI874639A patent/FI84473C/fi not_active IP Right Cessation
- 1987-10-21 HU HU874731A patent/HU198452B/hu unknown
-
1992
- 1992-04-15 GR GR910402209T patent/GR3004338T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1292001C (fr) | 1991-11-12 |
| PT85964B (pt) | 1990-07-31 |
| DK170095B1 (da) | 1995-05-22 |
| HUT45494A (en) | 1988-07-28 |
| FR2605630B1 (fr) | 1989-06-30 |
| JPH082873B2 (ja) | 1996-01-17 |
| PT85964A (fr) | 1987-11-01 |
| JPS63104957A (ja) | 1988-05-10 |
| FI874639L (fi) | 1988-04-23 |
| FR2605630A1 (fr) | 1988-04-29 |
| IE60280B1 (en) | 1994-06-29 |
| GR3004338T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-03-31 |
| ES2038684T3 (es) | 1993-08-01 |
| EP0267098A1 (fr) | 1988-05-11 |
| FI84473C (fi) | 1991-12-10 |
| US4879392A (en) | 1989-11-07 |
| FI874639A0 (fi) | 1987-10-21 |
| FI84473B (fi) | 1991-08-30 |
| HU198452B (en) | 1989-10-30 |
| DK550587A (da) | 1988-04-23 |
| EP0267098B1 (fr) | 1992-01-22 |
| DE3776273D1 (de) | 1992-03-05 |
| IE872652L (en) | 1988-04-22 |
| DK550587D0 (da) | 1987-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |