ATE67090T1 - Gegen oxydierung und verfaerbung stabilisierte arzneimittelzubereitungen. - Google Patents

Gegen oxydierung und verfaerbung stabilisierte arzneimittelzubereitungen.

Info

Publication number
ATE67090T1
ATE67090T1 AT87115281T AT87115281T ATE67090T1 AT E67090 T1 ATE67090 T1 AT E67090T1 AT 87115281 T AT87115281 T AT 87115281T AT 87115281 T AT87115281 T AT 87115281T AT E67090 T1 ATE67090 T1 AT E67090T1
Authority
AT
Austria
Prior art keywords
discoloration
against oxidation
stabilized against
medicinal preparations
preparations stabilized
Prior art date
Application number
AT87115281T
Other languages
English (en)
Inventor
Kuchi Sury Murthy
Michael Ray Harris
Gerard Clifford Hokanson
Robert George Reisch Jr
Mahdi Bakir Fawzi
Frank Stanley Waldman
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25445868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE67090(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE67090T1 publication Critical patent/ATE67090T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87115281T 1986-10-20 1987-10-19 Gegen oxydierung und verfaerbung stabilisierte arzneimittelzubereitungen. ATE67090T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/921,717 US4830853A (en) 1986-10-20 1986-10-20 Drug compositions stabilized against oxidation
EP87115281A EP0264887B1 (de) 1986-10-20 1987-10-19 Gegen Oxydierung und Verfärbung stabilisierte Arzneimittelzubereitungen

Publications (1)

Publication Number Publication Date
ATE67090T1 true ATE67090T1 (de) 1991-09-15

Family

ID=25445868

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87115281T ATE67090T1 (de) 1986-10-20 1987-10-19 Gegen oxydierung und verfaerbung stabilisierte arzneimittelzubereitungen.

Country Status (20)

Country Link
US (1) US4830853A (de)
EP (1) EP0264887B1 (de)
JP (1) JP2703906B2 (de)
KR (1) KR960000430B1 (de)
AT (1) ATE67090T1 (de)
AU (1) AU604061B2 (de)
CA (1) CA1297024C (de)
DE (1) DE3772924D1 (de)
DK (1) DK174916B1 (de)
ES (1) ES2040726T3 (de)
FI (1) FI100091B (de)
GR (1) GR3002698T3 (de)
HK (1) HK85694A (de)
IE (1) IE60773B1 (de)
NO (1) NO874352L (de)
NZ (1) NZ221954A (de)
PH (1) PH25582A (de)
PT (1) PT85942B (de)
SG (1) SG95494G (de)
ZA (1) ZA877132B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL88502A (en) * 1987-12-14 1993-04-04 Squibb & Sons Inc Pharmaceutical compositions containing an angiotensin converting enzyme inhibitor
US5366730A (en) * 1989-12-20 1994-11-22 Boehringer Mannheim Gmbh Stabilized compositions having human tissue type plasminogen activator enzymatic activity
DE3942145A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa-solubilisierung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
HU222489B1 (hu) * 1990-07-25 2003-07-28 Novartis Ag. Stabilizált gyógyszerkészítmények és eljárás az előállításukra
SI9111842A (sl) * 1991-11-25 1998-04-30 Krka Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
US6296871B1 (en) * 1998-04-12 2001-10-02 Ranbaxy Laboratories Limited Stable solid pharmaceutical compositions containing enalapril maleate
EP1736144B1 (de) * 1998-05-18 2015-11-11 Takeda Pharmaceutical Company Limited Im Munde zerfallende Tablette
CA2330581A1 (en) 1998-06-05 1999-12-09 Warner-Lambert Company Stabilization of compositions containing ace inhibitors using magnesium oxide
NZ333206A (en) 1998-12-08 2000-07-28 Bernard Charles Sherman Solid pharmaceutical compositions comprising a stable magnesium salt of quinapril that acts as a ACE (Angiotensin Converting Enzyme) inhibitor
US20030225124A1 (en) * 1999-08-31 2003-12-04 Spiridon Spireas Stable formulations of ACE inhibitors, and methods for preparation thereof
US6555551B1 (en) * 1999-08-31 2003-04-29 Mutual Pharmaceutical Co., Inc. Stable formulations of ACE inhibitors, and methods for preparation thereof
US20040157911A1 (en) * 1999-08-31 2004-08-12 Spiridon Spireas Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof
EP1467717A1 (de) * 2002-01-15 2004-10-20 Ranbaxy Laboratories Limited Stabile pharmazeutische zusammensetzungen mit ace-inhibitor(en)
WO2005002548A1 (en) * 2003-06-26 2005-01-13 Teva Pharmaceutical Industries Ltd. Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives
US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
WO2005041940A1 (en) * 2003-10-30 2005-05-12 Lupin Ltd. Stable formulations of ace inhibitors and methods for preparation thereof
GB2394660A (en) * 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
EA011862B1 (ru) * 2004-03-24 2009-06-30 Актавис Груп Хф. Композиции рамиприла
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20070232680A1 (en) * 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
WO2007120930A2 (en) * 2006-04-19 2007-10-25 Teva Pharmaceutical Industries Ltd. Stable pharmaceutical compositions of 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivatives
US8017168B2 (en) * 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
KR100808132B1 (ko) 2007-03-02 2008-02-29 고천일 음식물쓰레기 소멸처리장치
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
SI2654729T1 (sl) * 2010-12-24 2016-08-31 Krka, D.D., Novo Mesto Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino
US8568747B1 (en) 2012-10-05 2013-10-29 Silvergate Pharmaceuticals, Inc. Enalapril compositions
EP3193826B1 (de) 2014-07-31 2018-10-17 Pharmathen S.A. Im mund zerfallende filmzusammensetzung mit enalapril zur behandlung von bluthochdruck in einer pädiatrischen zielgruppe
US9463183B1 (en) 2015-10-30 2016-10-11 Silvergate Pharmaceuticals, Inc. Lisinopril formulations
US20180325813A1 (en) 2015-11-07 2018-11-15 Ftf Pharma Private Limited Oral solution of ace inhibitors
US9669008B1 (en) 2016-03-18 2017-06-06 Silvergate Pharmaceuticals, Inc. Enalapril formulations
MX2020007368A (es) * 2018-01-11 2020-10-12 Viropharma Biologics Llc Composiciones estables de corticosteroides.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE569430A (de) * 1957-07-17
US3697641A (en) * 1970-01-02 1972-10-10 Gerhard W Ahrens Nonhygroscopic non-sugarbase noncariogenic-vitamin c releasable base material for use in the preparation of suckable tablets,lozenges and chocolate
DE3175410D1 (en) * 1980-07-29 1986-11-06 Sanofi Sa Acid stabilized compositions of thieno-pyridine derived compounds and process for preventing degradation of such compounds
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4442089A (en) * 1982-07-06 1984-04-10 E. R. Squibb & Sons, Inc. Method for treating glaucoma with topical or systemic ACE inhibitor compositions
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4666705A (en) * 1985-06-03 1987-05-19 E. R. Squibb & Sons, Inc. Controlled release formulation
US4656188A (en) * 1985-10-09 1987-04-07 Merck & Co., Inc. Ace inhibitors in macular degeneration

Also Published As

Publication number Publication date
DK543587D0 (da) 1987-10-16
JP2703906B2 (ja) 1998-01-26
PH25582A (en) 1991-08-08
NO874352D0 (no) 1987-10-19
NO874352L (no) 1988-04-21
AU604061B2 (en) 1990-12-06
IE60773B1 (en) 1994-08-10
FI874594L (fi) 1988-04-21
GR3002698T3 (en) 1993-01-25
PT85942A (en) 1987-11-01
PT85942B (pt) 1990-07-31
KR960000430B1 (ko) 1996-01-06
DE3772924D1 (de) 1991-10-17
FI874594A0 (fi) 1987-10-19
DK543587A (da) 1988-04-21
FI100091B (fi) 1997-09-30
NZ221954A (en) 1990-03-27
EP0264887A1 (de) 1988-04-27
AU7939787A (en) 1988-04-21
KR880004811A (ko) 1988-06-27
HK85694A (en) 1994-08-26
JPS63104931A (ja) 1988-05-10
DK174916B1 (da) 2004-02-23
CA1297024C (en) 1992-03-10
IE872550L (en) 1988-04-20
ZA877132B (en) 1989-04-26
SG95494G (en) 1994-10-28
US4830853A (en) 1989-05-16
EP0264887B1 (de) 1991-09-11
ES2040726T3 (es) 1993-11-01

Similar Documents

Publication Publication Date Title
ATE67090T1 (de) Gegen oxydierung und verfaerbung stabilisierte arzneimittelzubereitungen.
ATE65915T1 (de) Stabilisierte arzneimittelzubereitungen.
DK94088A (da) Stabiliserede praeparater
ATE61582T1 (de) Styrylpyrazole, -isoxazole und analoga mit 5lipoxygenase-inhibitor-wirkung und pharmazeutische zusammensetzungen damit.
ATE72991T1 (de) Nasale verabreichung von arzneimitteln.
DK249389D0 (da) 2-acylamino-benzothiazol-forbindelser og deres anvendelse til fremstilling af laegemidler til behandling af tumorer
FI882263A7 (fi) Vanadiinitetrakloridin stabilointi.
DK166789A (da) Substituerede flavonoidforbindelser samt laegemidler indeholdende disse
FI864176A7 (fi) Nosto- ja laskumekanismi kaikenlaatuisia työpöytiä varten.
ES2032797T3 (es) Agente terapeutico para el tratamiento de la enfermedad ulcera peptica.
ATE57681T1 (de) Carboxanilide.
ATE113844T1 (de) Erzeugnisse, enthaltend verapamil und trandolapril.
DK656889D0 (da) Hidtil ukendte forbindelser
ES2033859T3 (es) Acidos y esteres 2-amino-3-aroil-gamma-oxobencenbutanoicos.
ATE87912T1 (de) Substituierte tetrahydropyridinoxime und ihre verwendung als cholinergische heilmittel.

Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time