ATE63906T1 - 3,5-disubstituierte 4,5-dihydroisoxazole als transglutaminasehemmer. - Google Patents
3,5-disubstituierte 4,5-dihydroisoxazole als transglutaminasehemmer.Info
- Publication number
- ATE63906T1 ATE63906T1 AT87103700T AT87103700T ATE63906T1 AT E63906 T1 ATE63906 T1 AT E63906T1 AT 87103700 T AT87103700 T AT 87103700T AT 87103700 T AT87103700 T AT 87103700T AT E63906 T1 ATE63906 T1 AT E63906T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydroisoxazoles
- disubstituted
- transglutaminase inhibitors
- transglutaminase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83974386A | 1986-03-14 | 1986-03-14 | |
EP87103700A EP0237082B1 (de) | 1986-03-14 | 1987-03-13 | 3,5-disubstituierte 4,5-Dihydroisoxazole als Transglutaminasehemmer |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE63906T1 true ATE63906T1 (de) | 1991-06-15 |
Family
ID=25280527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT87103700T ATE63906T1 (de) | 1986-03-14 | 1987-03-13 | 3,5-disubstituierte 4,5-dihydroisoxazole als transglutaminasehemmer. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0237082B1 (de) |
JP (1) | JPS62252779A (de) |
KR (1) | KR900006545B1 (de) |
AT (1) | ATE63906T1 (de) |
AU (1) | AU599636B2 (de) |
DE (1) | DE3770294D1 (de) |
DK (1) | DK130387A (de) |
ES (1) | ES2038609T3 (de) |
GR (1) | GR3002022T3 (de) |
HU (2) | HU199809B (de) |
IL (1) | IL81887A0 (de) |
NZ (1) | NZ219607A (de) |
ZA (1) | ZA871860B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2738486B2 (ja) * | 1992-11-20 | 1998-04-08 | ファイザー製薬株式会社 | 抗炎症剤としての新規なイソオキサゾリン類 |
WO1995012611A1 (en) * | 1993-11-01 | 1995-05-11 | Japat Ltd. | Endothelin receptor antagonists |
US5710159A (en) * | 1996-05-09 | 1998-01-20 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
IL118325A0 (en) * | 1995-05-25 | 1996-10-31 | Pont Merck And Pharmaceutical | Integrin receptor antagonists and pharmaceutical compositions containing them |
TR199800767T2 (xx) | 1995-10-30 | 1998-07-21 | Smithkline Beecham Corporation | Proteaz engelleyicileri. |
US6586466B2 (en) | 1995-10-30 | 2003-07-01 | Smithkline Beecham Corporation | Carbohydrazide-protease inhibitors |
ATE320249T1 (de) | 1997-07-08 | 2006-04-15 | Ono Pharmaceutical Co | Aminosäurederivate |
TWI245035B (en) | 1998-06-26 | 2005-12-11 | Ono Pharmaceutical Co | Amino acid derivatives and a pharmaceutical composition comprising the derivatives |
EP1097929A4 (de) | 1998-07-14 | 2005-12-21 | Ono Pharmaceutical Co | Amino-säure-derivate und drogen, die diese als aktiven bestandteil enthalten |
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
AU1588901A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003513924A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
US7071184B2 (en) | 2000-03-21 | 2006-07-04 | Smithkline Beecham Corporation | Protease inhibitors |
US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
DE60336754D1 (de) | 2002-02-14 | 2011-05-26 | Univ R | Enzymbehandlung von nahrungsmitteln für zöliakie-sprue |
US6902781B2 (en) | 2002-04-08 | 2005-06-07 | Konica Corporation | Ink-jet recording medium, silica particles and silica dispersion |
US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
CA2487247A1 (en) | 2002-05-14 | 2003-11-27 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
ES2383595T3 (es) | 2002-11-20 | 2012-06-22 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimiento de diagnóstico de la celiaquía |
US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
US7628985B2 (en) | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
GB0515003D0 (en) | 2005-07-21 | 2005-08-31 | Univ Aston | Medical devices and coatings therefor |
MX2009009780A (es) | 2007-03-16 | 2010-05-20 | Univ Leland Stanford Junior | Terapia de enzima de combinacion para la digestion de gluten dietetico. |
CL2008001724A1 (es) * | 2007-06-13 | 2008-08-08 | Bristol Myers Squibb Co | Compuestos derivados de analogos dipeptidos, inhibidores del factor de coagulacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de un trastorno tromboembolico, infarto de miocardio, trombosis, ate |
EP2219594A4 (de) * | 2007-11-27 | 2015-01-14 | Univ Manitoba | Verwendung eines transglutaminase-inhibitors zur hautbehandlung |
US8765735B2 (en) | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US9149465B2 (en) | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US8927551B2 (en) | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4283403A (en) * | 1976-06-14 | 1981-08-11 | Eli Lilly And Company | Substituted isoxazolines for control of plant phytopathogens |
WO1981001145A1 (en) * | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
US4481190A (en) | 1982-12-21 | 1984-11-06 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists |
-
1987
- 1987-03-13 KR KR1019870002237A patent/KR900006545B1/ko not_active IP Right Cessation
- 1987-03-13 NZ NZ219607A patent/NZ219607A/en unknown
- 1987-03-13 AT AT87103700T patent/ATE63906T1/de not_active IP Right Cessation
- 1987-03-13 IL IL81887A patent/IL81887A0/xx not_active IP Right Cessation
- 1987-03-13 EP EP87103700A patent/EP0237082B1/de not_active Expired - Lifetime
- 1987-03-13 AU AU69987/87A patent/AU599636B2/en not_active Ceased
- 1987-03-13 HU HU885805A patent/HU199809B/hu not_active IP Right Cessation
- 1987-03-13 ES ES198787103700T patent/ES2038609T3/es not_active Expired - Lifetime
- 1987-03-13 JP JP62059922A patent/JPS62252779A/ja active Pending
- 1987-03-13 DK DK130387A patent/DK130387A/da not_active Application Discontinuation
- 1987-03-13 HU HU871105A patent/HU201032B/hu not_active IP Right Cessation
- 1987-03-13 DE DE8787103700T patent/DE3770294D1/de not_active Expired - Fee Related
- 1987-03-13 ZA ZA871860A patent/ZA871860B/xx unknown
-
1991
- 1991-05-30 GR GR90400772T patent/GR3002022T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ219607A (en) | 1990-11-27 |
ZA871860B (en) | 1988-10-26 |
ES2038609T3 (es) | 1993-08-01 |
EP0237082A2 (de) | 1987-09-16 |
EP0237082B1 (de) | 1991-05-29 |
HU199809B (en) | 1990-03-28 |
AU599636B2 (en) | 1990-07-26 |
KR900006545B1 (ko) | 1990-09-13 |
JPS62252779A (ja) | 1987-11-04 |
GR3002022T3 (en) | 1992-12-30 |
DK130387A (da) | 1987-09-15 |
HUT44244A (en) | 1988-02-29 |
AU6998787A (en) | 1987-09-17 |
DE3770294D1 (de) | 1991-07-04 |
KR870008863A (ko) | 1987-10-21 |
HU201032B (en) | 1990-09-28 |
DK130387D0 (da) | 1987-03-13 |
EP0237082A3 (en) | 1988-09-14 |
IL81887A0 (en) | 1987-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |