ATE61051T1 - Substituierte pyrimidinamide von oelsaeure oder linolsaeure als inhibitoren von acyl-coa cholesterin-acyltransferase. - Google Patents

Substituierte pyrimidinamide von oelsaeure oder linolsaeure als inhibitoren von acyl-coa cholesterin-acyltransferase.

Info

Publication number
ATE61051T1
ATE61051T1 AT87106097T AT87106097T ATE61051T1 AT E61051 T1 ATE61051 T1 AT E61051T1 AT 87106097 T AT87106097 T AT 87106097T AT 87106097 T AT87106097 T AT 87106097T AT E61051 T1 ATE61051 T1 AT E61051T1
Authority
AT
Austria
Prior art keywords
acid
acyl
inhibitors
pyrimidinamides
oilic
Prior art date
Application number
AT87106097T
Other languages
English (en)
Inventor
Ann Holmes
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE61051T1 publication Critical patent/ATE61051T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT87106097T 1986-04-28 1987-04-27 Substituierte pyrimidinamide von oelsaeure oder linolsaeure als inhibitoren von acyl-coa cholesterin-acyltransferase. ATE61051T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/856,551 US4722927A (en) 1986-04-28 1986-04-28 Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
EP87106097A EP0245687B1 (de) 1986-04-28 1987-04-27 Substituierte Pyrimidinamide von Ölsäure oder Linolsäure als Inhibitoren von Acyl-CoA Cholesterin-Acyltransferase

Publications (1)

Publication Number Publication Date
ATE61051T1 true ATE61051T1 (de) 1991-03-15

Family

ID=25323922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87106097T ATE61051T1 (de) 1986-04-28 1987-04-27 Substituierte pyrimidinamide von oelsaeure oder linolsaeure als inhibitoren von acyl-coa cholesterin-acyltransferase.

Country Status (8)

Country Link
US (1) US4722927A (de)
EP (1) EP0245687B1 (de)
JP (1) JPS62258366A (de)
AT (1) ATE61051T1 (de)
CA (1) CA1264747A (de)
DE (1) DE3768138D1 (de)
ES (1) ES2037679T3 (de)
GR (1) GR3001523T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166214A (en) * 1988-12-05 1992-11-24 Du Pont Merck Pharmaceutical Company Use of imidazoles for the treatment of atherosclerosis
US5318984A (en) * 1988-12-05 1994-06-07 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
US5179117A (en) * 1991-12-20 1993-01-12 Du Pont Merck Pharmaceutical Company Antihypercholesterolemic 2-substituted imidazoles
JPH05320143A (ja) * 1992-03-18 1993-12-03 Mochida Pharmaceut Co Ltd 新規ピリミジン誘導体
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
KR950701621A (ko) * 1992-05-28 1995-04-28 알렌 제이. 스피겔 아실 조효소a : 콜레스테롤 아실 전이효소(acat)의 억제제로서 신규한 n- 아릴 및 n- 헤테로아릴우레아 유도체(new n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a : cholesterol acyl transferase(acat)
CA2115915A1 (en) * 1992-07-20 1994-02-03 Kenji Hayashi Benzene derivatives
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
US6365411B1 (en) 1999-06-09 2002-04-02 University Of Cincinnati Rain forest plant extract with cellular cholesterol lowering properties
US6730703B2 (en) * 2000-02-02 2004-05-04 Warner-Lambert Company Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5619344B2 (de) * 1972-11-11 1981-05-07
DE2856856A1 (de) * 1978-01-09 1979-07-12 Sandoz Ag Fettsaeure-amid-und-hydracid derivate, ihre herstellung und ihre verwendung als pharmazeutika
CH655717A5 (de) * 1982-09-13 1986-05-15 Sandoz Ag Chloracetamide.
EP0175652A3 (de) * 1984-09-20 1988-07-20 Ciba-Geigy Ag 5-Acylaminopyrimidine

Also Published As

Publication number Publication date
ES2037679T3 (es) 1993-07-01
EP0245687B1 (de) 1991-02-27
GR3001523T3 (en) 1992-11-23
US4722927A (en) 1988-02-02
CA1264747A (en) 1990-01-23
JPS62258366A (ja) 1987-11-10
EP0245687A1 (de) 1987-11-19
DE3768138D1 (de) 1991-04-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee