ES2037679T3 - Procedimiento para preparar pirimidinamidas sustituidas de acido oleico o linolenico como inhibidores de acil-coa colesterol aciltransferasa. - Google Patents
Procedimiento para preparar pirimidinamidas sustituidas de acido oleico o linolenico como inhibidores de acil-coa colesterol aciltransferasa.Info
- Publication number
- ES2037679T3 ES2037679T3 ES198787106097T ES87106097T ES2037679T3 ES 2037679 T3 ES2037679 T3 ES 2037679T3 ES 198787106097 T ES198787106097 T ES 198787106097T ES 87106097 T ES87106097 T ES 87106097T ES 2037679 T3 ES2037679 T3 ES 2037679T3
- Authority
- ES
- Spain
- Prior art keywords
- acil
- pyrimidinamides
- procedure
- linolenic acid
- acid substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
CIERTAS PIRIDINOAMIDAS DISUSTITUIDAS DE ACIDOS OLEICO Y LINOLEICO SON POETENTES INHIBIDORES DE LA ENZIMA ACIL-COA: COLESTEROL ACILTRANSFERASA Y, POR LO TANTO, SON UTILES AGENTES PARA INHIBIR LA ABSORCION INTESTINAL DEL COLESTEROL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/856,551 US4722927A (en) | 1986-04-28 | 1986-04-28 | Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2037679T3 true ES2037679T3 (es) | 1993-07-01 |
Family
ID=25323922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787106097T Expired - Lifetime ES2037679T3 (es) | 1986-04-28 | 1987-04-27 | Procedimiento para preparar pirimidinamidas sustituidas de acido oleico o linolenico como inhibidores de acil-coa colesterol aciltransferasa. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4722927A (es) |
EP (1) | EP0245687B1 (es) |
JP (1) | JPS62258366A (es) |
AT (1) | ATE61051T1 (es) |
CA (1) | CA1264747A (es) |
DE (1) | DE3768138D1 (es) |
ES (1) | ES2037679T3 (es) |
GR (1) | GR3001523T3 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166214A (en) * | 1988-12-05 | 1992-11-24 | Du Pont Merck Pharmaceutical Company | Use of imidazoles for the treatment of atherosclerosis |
US5318984A (en) * | 1988-12-05 | 1994-06-07 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
US5179117A (en) * | 1991-12-20 | 1993-01-12 | Du Pont Merck Pharmaceutical Company | Antihypercholesterolemic 2-substituted imidazoles |
JPH05320143A (ja) * | 1992-03-18 | 1993-12-03 | Mochida Pharmaceut Co Ltd | 新規ピリミジン誘導体 |
US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
CA2134359C (en) * | 1992-05-28 | 1997-07-01 | Ernest S. Hamanaka | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
EP0609457B1 (en) * | 1992-07-20 | 1997-10-29 | Eisai Co., Ltd. | Benzene derivative |
NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
GB2321455A (en) | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
US6365411B1 (en) | 1999-06-09 | 2002-04-02 | University Of Cincinnati | Rain forest plant extract with cellular cholesterol lowering properties |
KR20020073574A (ko) * | 2000-02-02 | 2002-09-27 | 워너-램버트 캄파니 | 피지선 장애 치료용 콜레스테롤 에스테르 및 왁스에스테르 합성 이중 억제제 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5619344B2 (es) * | 1972-11-11 | 1981-05-07 | ||
DE2856856A1 (de) * | 1978-01-09 | 1979-07-12 | Sandoz Ag | Fettsaeure-amid-und-hydracid derivate, ihre herstellung und ihre verwendung als pharmazeutika |
CH655717A5 (de) * | 1982-09-13 | 1986-05-15 | Sandoz Ag | Chloracetamide. |
EP0175652A3 (de) * | 1984-09-20 | 1988-07-20 | Ciba-Geigy Ag | 5-Acylaminopyrimidine |
-
1986
- 1986-04-28 US US06/856,551 patent/US4722927A/en not_active Expired - Fee Related
-
1987
- 1987-03-11 CA CA000531739A patent/CA1264747A/en not_active Expired - Fee Related
- 1987-04-27 DE DE8787106097T patent/DE3768138D1/de not_active Expired - Fee Related
- 1987-04-27 AT AT87106097T patent/ATE61051T1/de not_active IP Right Cessation
- 1987-04-27 JP JP62102144A patent/JPS62258366A/ja active Pending
- 1987-04-27 EP EP87106097A patent/EP0245687B1/en not_active Expired - Lifetime
- 1987-04-27 ES ES198787106097T patent/ES2037679T3/es not_active Expired - Lifetime
-
1991
- 1991-02-28 GR GR91400129T patent/GR3001523T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US4722927A (en) | 1988-02-02 |
EP0245687B1 (en) | 1991-02-27 |
GR3001523T3 (en) | 1992-11-23 |
ATE61051T1 (de) | 1991-03-15 |
CA1264747A (en) | 1990-01-23 |
DE3768138D1 (de) | 1991-04-04 |
JPS62258366A (ja) | 1987-11-10 |
EP0245687A1 (en) | 1987-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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