ATE554768T1 - 1-aryl-4-substituierte isochinoline - Google Patents
1-aryl-4-substituierte isochinolineInfo
- Publication number
- ATE554768T1 ATE554768T1 AT05747952T AT05747952T ATE554768T1 AT E554768 T1 ATE554768 T1 AT E554768T1 AT 05747952 T AT05747952 T AT 05747952T AT 05747952 T AT05747952 T AT 05747952T AT E554768 T1 ATE554768 T1 AT E554768T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- receptors
- compounds
- formula
- isoquinolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56918204P | 2004-05-08 | 2004-05-08 | |
PCT/US2005/015959 WO2005110991A1 (en) | 2004-05-08 | 2005-05-06 | 1-aryl-4-substituted isoquinolines |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE554768T1 true ATE554768T1 (de) | 2012-05-15 |
Family
ID=35394112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05747952T ATE554768T1 (de) | 2004-05-08 | 2005-05-06 | 1-aryl-4-substituierte isochinoline |
Country Status (9)
Country | Link |
---|---|
US (1) | US7915288B2 (de) |
EP (1) | EP1745024B1 (de) |
JP (2) | JP5220407B2 (de) |
CN (1) | CN1980895A (de) |
AT (1) | ATE554768T1 (de) |
AU (1) | AU2005243149A1 (de) |
CA (1) | CA2564517A1 (de) |
ES (1) | ES2384619T3 (de) |
WO (1) | WO2005110991A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR049102A1 (es) * | 2004-05-17 | 2006-06-28 | Tibotec Pharm Ltd | Derivados de fenil - 1, 5 - dihidro - pirido[3,2 -b]indol - 2 - onas 5- sustituidos y derivados de fenil - 2 - oxo - 1,2 - dihidro - benzo[4, 5]furo[3, 2 -b ]piridin - 3 - carbonitrilo, composiciones farmaceuticas que los contienen y su uso como medicamento con actividad inhibitoria del virus hiv. |
CA2593005A1 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof |
EP2489660A1 (de) * | 2008-03-20 | 2012-08-22 | Abbott Laboratories | Verfahren zum Herstellen von Mitteln für das zentrale Nervensystem, die TRPV1-Antagonisten sind |
AU2010258800B2 (en) * | 2009-06-09 | 2013-10-10 | Nantbio, Inc. | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
CN103664876B (zh) * | 2013-11-01 | 2016-04-20 | 苏州东南药业股份有限公司 | 喹啉类衍生物及其用途 |
WO2016067090A1 (en) | 2014-10-26 | 2016-05-06 | King Abdullah University Of Science And Technology | Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv) |
US20220227729A1 (en) | 2019-05-21 | 2022-07-21 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2811312A1 (de) * | 1978-03-16 | 1979-09-27 | Hoechst Ag | Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln |
DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
JPS57203068A (en) * | 1981-06-08 | 1982-12-13 | Teikoku Hormone Mfg Co Ltd | Novel 1-phenylisoquinoline derivative |
DE69720515T2 (de) * | 1996-12-18 | 2004-02-19 | Neurogen Corp., Branford | Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren |
GB0008694D0 (en) * | 2000-04-07 | 2000-05-31 | Novartis Ag | Organic compounds |
US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
AU2003218374A1 (en) * | 2002-03-28 | 2003-10-13 | Neurogen Corporation | Substituted tetrahydroisoquinolines as c5a receptor modulators |
CA2539479C (en) * | 2003-09-23 | 2010-07-06 | Merck & Co., Inc. | Isoquinoline potassium channel inhibitors |
-
2005
- 2005-05-06 AU AU2005243149A patent/AU2005243149A1/en not_active Abandoned
- 2005-05-06 EP EP05747952A patent/EP1745024B1/de not_active Not-in-force
- 2005-05-06 AT AT05747952T patent/ATE554768T1/de active
- 2005-05-06 JP JP2007511662A patent/JP5220407B2/ja not_active Expired - Fee Related
- 2005-05-06 WO PCT/US2005/015959 patent/WO2005110991A1/en active Application Filing
- 2005-05-06 CN CNA2005800228962A patent/CN1980895A/zh active Pending
- 2005-05-06 US US11/587,906 patent/US7915288B2/en not_active Expired - Fee Related
- 2005-05-06 CA CA002564517A patent/CA2564517A1/en not_active Abandoned
- 2005-05-06 ES ES05747952T patent/ES2384619T3/es active Active
-
2012
- 2012-05-16 JP JP2012112249A patent/JP2012180365A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1745024A4 (de) | 2008-01-09 |
US7915288B2 (en) | 2011-03-29 |
EP1745024B1 (de) | 2012-04-25 |
ES2384619T3 (es) | 2012-07-09 |
JP5220407B2 (ja) | 2013-06-26 |
AU2005243149A1 (en) | 2005-11-24 |
WO2005110991A1 (en) | 2005-11-24 |
CN1980895A (zh) | 2007-06-13 |
JP2012180365A (ja) | 2012-09-20 |
EP1745024A1 (de) | 2007-01-24 |
JP2007536266A (ja) | 2007-12-13 |
US20070249665A1 (en) | 2007-10-25 |
CA2564517A1 (en) | 2005-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE552253T1 (de) | 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren | |
TW200608976A (en) | 4,5-disubstituted-2-aryl pyrimidines | |
ATE554768T1 (de) | 1-aryl-4-substituierte isochinoline | |
WO2006042102A3 (en) | Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds | |
MA33178B1 (fr) | Pipéridines substituées comme antagonistes de ccr3 | |
EA200970207A1 (ru) | Соединения пиридо[2,3-d]пиримидинона и их применение в качестве pi3 ингибиторов | |
AP1503A (en) | Benzimidazole and pyridylimidazole derivatives as ligands for GABA receptors | |
EA200301121A1 (ru) | Тартраты 5,8,14-триазатетрацикло[10.3.1.02,11.04,9]гексадека-2(11),3,5,7,9-пентаена | |
MX2013004491A (es) | Boronatos como inhibidores de arginasa. | |
ATE362932T1 (de) | Azaindolverbindungen als kinaseinhibitoren | |
EA201171328A1 (ru) | Производное замещенного изохинолина | |
EA200701036A1 (ru) | Лактамные соединения и их применение в качестве фармацевтических препаратов | |
EA200601391A1 (ru) | Производные хинолина для применения в качестве микобактериальных ингибиторов | |
MY171899A (en) | New cyclohexylamine derivatives having ?2 adrenergic agonist and m3 muscarinic antagonist activities | |
MX2010006799A (es) | Benzofuropirimidinonas como inhibidores de la proteina cinasa. | |
WO2009115517A3 (en) | Pyridines and pyrazines as inhibitors of pi3k | |
EA201070423A1 (ru) | Диарильные соединения оксадиазолов | |
TW200800981A (en) | 8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists | |
UA92670C2 (ru) | Пиразолиновые соединения и их фармацевтическое применение, композиция на их основе | |
DK1651615T3 (da) | Pyridazinyl-piperaziner og anvendelse deraf som histamin-H3-receptorligander | |
EA200900048A1 (ru) | Новые карбонилированные (аза)циклогексаны в качестве лигандов d3 рецептора дофамина | |
BR112013016595A2 (pt) | inibidores de neprilisina | |
MX2011011156A (es) | COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2. | |
MX2010002171A (es) | Compuestos 8-azabiciclo[3.2.1] octil-2 hidroxibenzamida como antagonistas de los receptores opioides mu. | |
MX2009004746A (es) | Derivados de 1,2,4-triazol como inhibidores del receptor sigma. |