ATE546543T1 - Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase - Google Patents
Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretaseInfo
- Publication number
- ATE546543T1 ATE546543T1 AT08765357T AT08765357T ATE546543T1 AT E546543 T1 ATE546543 T1 AT E546543T1 AT 08765357 T AT08765357 T AT 08765357T AT 08765357 T AT08765357 T AT 08765357T AT E546543 T1 ATE546543 T1 AT E546543T1
- Authority
- AT
- Austria
- Prior art keywords
- epha4
- secretase
- screening method
- new substrate
- gamma secretase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94268707P | 2007-06-08 | 2007-06-08 | |
| PCT/JP2008/060567 WO2008150010A1 (ja) | 2007-06-08 | 2008-06-09 | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE546543T1 true ATE546543T1 (de) | 2012-03-15 |
Family
ID=40093812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08765357T ATE546543T1 (de) | 2007-06-08 | 2008-06-09 | Screening-verfahren mit verwendung des neuen substrats epha4 für gamma-sekretase |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7910324B2 (de) |
| EP (1) | EP2166110B1 (de) |
| JP (1) | JP5511377B2 (de) |
| AT (1) | ATE546543T1 (de) |
| WO (1) | WO2008150010A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008150010A1 (ja) | 2007-06-08 | 2008-12-11 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
| JPWO2009011426A1 (ja) * | 2007-07-19 | 2010-09-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｍｅｔを利用したスクリーニング方法 |
| EP2192181A4 (de) * | 2007-08-01 | 2010-12-08 | Eisai R&D Man Co Ltd | Screening-verfahren mit nutzung des neuen substrats c-ret für gamma-sekretase |
| EP2219028B1 (de) | 2007-11-15 | 2012-09-12 | Eisai R&D Management Co., Ltd. | Screening-verfahren mit nutzung des neuen substrats epha7 für gamma-sekretase |
| DK2223999T3 (en) | 2007-11-30 | 2017-12-18 | Eisai R&D Man Co Ltd | EPHA4 POLYPEPTIDE WITH UNKNOWN ACTIVITY AND USE THEREOF |
| WO2010141974A1 (en) * | 2009-06-10 | 2010-12-16 | The University Of Melbourne | Therapeutic applications |
| DK2653552T3 (en) | 2010-12-17 | 2017-01-16 | Eisai R&D Man Co Ltd | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 DIVISION REACTION AS INDICATOR |
| WO2012147798A1 (ja) | 2011-04-25 | 2012-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | EphA4細胞外ドメインの測定による認知機能障害を伴う神経系疾患の検出方法 |
| AR105938A1 (es) | 2015-09-08 | 2017-11-22 | Eisai R&D Man Co Ltd | Anticuerpo anti-epha4 |
| CA3003294A1 (en) * | 2015-10-27 | 2017-05-04 | The University Of Queensland | Modified epha4 and uses thereof |
| PE20220570A1 (es) | 2019-07-01 | 2022-04-20 | Eisai Randd Man Co Ltd | Anticuerpo anti-epha4 humano |
| CN116710133A (zh) * | 2020-12-24 | 2023-09-05 | 卫材R&D管理有限公司 | 肌萎缩侧索硬化的治疗用药物组合物 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020068361A1 (en) * | 1997-04-08 | 2002-06-06 | Douglas Clary | Methods of evaluating specific cellular functions of receptor protein tyrosine kinases in a ligand independent manner |
| WO1998045708A1 (en) | 1997-04-08 | 1998-10-15 | Sugen, Inc. | Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases |
| US20070015145A1 (en) | 2001-08-14 | 2007-01-18 | Clifford Woolf | Nucleic acid and amino acid sequences involved in pain |
| US20070026409A1 (en) * | 2001-08-14 | 2007-02-01 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| US20060241074A1 (en) * | 2001-08-14 | 2006-10-26 | The General Hospital Corporation | Methods for treatment of pain |
| JP2003169699A (ja) * | 2001-12-10 | 2003-06-17 | Japan Science & Technology Corp | 特異的γプロテアーゼ阻害剤のスクリーニング方法 |
| JP2004000060A (ja) | 2002-05-31 | 2004-01-08 | Otsuka Pharmaceut Co Ltd | アミロイドβ産生に影響を与える化合物のスクリーニング方法 |
| ES2293047T3 (es) | 2002-11-26 | 2008-03-16 | PHARMACIA & UPJOHN COMPANY LLC | Sustratos basados en notch solubles para gamma secretasa y procedimientos y composiciones para usarlos. |
| EP1693449A4 (de) | 2003-11-10 | 2007-07-25 | Osaka Ind Promotion Org | Zellfreies notch-spaltungsanalyseverfahren und arzneistoff-screening-verfahren |
| JP2007525203A (ja) | 2004-02-27 | 2007-09-06 | オンコセラピー・サイエンス株式会社 | ＰＲＣおよびＰＤＡＣａの治療標的としてのＥｐｈＡ４ |
| EP1662259A1 (de) * | 2004-11-25 | 2006-05-31 | Cellzome Ag | Verwendung von Eph Rezeptor-Inhibitoren zur Behandlung von neurodegenerativen Erkrankungen |
| GB0427023D0 (en) * | 2004-12-09 | 2005-01-12 | Merck Sharp & Dohme | Assay method |
| US20070051145A1 (en) * | 2005-09-02 | 2007-03-08 | Ez Trend Technology Co.,Ltd | Electric lock |
| EP1947193A1 (de) * | 2007-01-17 | 2008-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Screening-Verfahren für antidiabetische Zusammensetzungen |
| WO2008150010A1 (ja) | 2007-06-08 | 2008-12-11 | Eisai R & D Management Co., Ltd. | γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法 |
| US20090023158A1 (en) * | 2007-07-13 | 2009-01-22 | Elan Pharmaceuticals, Inc. | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase |
| JPWO2009011426A1 (ja) * | 2007-07-19 | 2010-09-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｍｅｔを利用したスクリーニング方法 |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| DK2223999T3 (en) * | 2007-11-30 | 2017-12-18 | Eisai R&D Man Co Ltd | EPHA4 POLYPEPTIDE WITH UNKNOWN ACTIVITY AND USE THEREOF |
| US20100113415A1 (en) * | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
-
2008
- 2008-06-09 WO PCT/JP2008/060567 patent/WO2008150010A1/ja active Application Filing
- 2008-06-09 EP EP08765357A patent/EP2166110B1/de active Active
- 2008-06-09 AT AT08765357T patent/ATE546543T1/de active
- 2008-06-09 JP JP2009517923A patent/JP5511377B2/ja active Active
- 2008-06-09 US US12/135,307 patent/US7910324B2/en active Active
-
2011
- 2011-01-19 US US13/009,127 patent/US8137926B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5511377B2 (ja) | 2014-06-04 |
| EP2166110B1 (de) | 2012-02-22 |
| EP2166110A1 (de) | 2010-03-24 |
| JPWO2008150010A1 (ja) | 2010-08-26 |
| US7910324B2 (en) | 2011-03-22 |
| US20090142788A1 (en) | 2009-06-04 |
| US8137926B2 (en) | 2012-03-20 |
| WO2008150010A1 (ja) | 2008-12-11 |
| EP2166110A4 (de) | 2010-07-28 |
| US20110111444A1 (en) | 2011-05-12 |
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