ATE537249T1 - Wiedergewinnung von gewebefunktion nach verabreichung von b-zellen an verletztes gewebe - Google Patents

Wiedergewinnung von gewebefunktion nach verabreichung von b-zellen an verletztes gewebe

Info

Publication number
ATE537249T1
ATE537249T1 AT06750473T AT06750473T ATE537249T1 AT E537249 T1 ATE537249 T1 AT E537249T1 AT 06750473 T AT06750473 T AT 06750473T AT 06750473 T AT06750473 T AT 06750473T AT E537249 T1 ATE537249 T1 AT E537249T1
Authority
AT
Austria
Prior art keywords
cells
tissue
administration
recovery
injured tissue
Prior art date
Application number
AT06750473T
Other languages
English (en)
Inventor
Mark C Poznansky
Traci T Goodchild
Mark T Ungs
Nicolas A F Chronos
Nadine Weich
Original Assignee
Actx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actx Inc filed Critical Actx Inc
Application granted granted Critical
Publication of ATE537249T1 publication Critical patent/ATE537249T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4612—B-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46432—Nervous system antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT06750473T 2005-04-18 2006-04-18 Wiedergewinnung von gewebefunktion nach verabreichung von b-zellen an verletztes gewebe ATE537249T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67241605P 2005-04-18 2005-04-18
PCT/US2006/014445 WO2006113647A2 (en) 2005-04-18 2006-04-18 Recovery of tissue function following administration of b cells to injured tissue

Publications (1)

Publication Number Publication Date
ATE537249T1 true ATE537249T1 (de) 2011-12-15

Family

ID=37115830

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06750473T ATE537249T1 (de) 2005-04-18 2006-04-18 Wiedergewinnung von gewebefunktion nach verabreichung von b-zellen an verletztes gewebe

Country Status (5)

Country Link
US (2) US7695712B2 (de)
EP (1) EP1877544B1 (de)
JP (1) JP4659092B2 (de)
AT (1) ATE537249T1 (de)
WO (1) WO2006113647A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7695712B2 (en) * 2005-04-18 2010-04-13 Actx, Inc. Recovery of tissue function following administration of B cells to injured tissue
US9220813B2 (en) * 2005-04-18 2015-12-29 Holy Cross Hospital, Inc. Cell therapy for limiting overzealous inflammatory reactions in tissue healing
WO2008103336A1 (en) * 2007-02-21 2008-08-28 Cook Incorporated Methods for intravascular engraftment in heart
KR101922118B1 (ko) 2012-08-27 2018-11-26 삼성전자주식회사 플렉서블 반도체소자 및 그 제조방법
WO2014110180A1 (en) 2013-01-12 2014-07-17 Cesca Therapeutics, Inc. Rapid infusion of autologous bone marrow derived stem cells
US20150118199A1 (en) 2013-10-28 2015-04-30 Biocardia, Inc. Methods of measuring potential for therapeutic potency and defining dosages for autologous cell therapies
US9775816B2 (en) 2013-11-07 2017-10-03 The General Hospital Corporation Eluting matrix and uses thereof
EP3914265A4 (de) * 2019-01-23 2023-02-01 The General Hospital Corporation B-zell-immuntherapie
US20230158074A1 (en) * 2020-04-16 2023-05-25 The General Hospital Corporation B cell immunomodulatory therapy for acute respiratory distress syndrome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US6465251B1 (en) * 1996-11-13 2002-10-15 Dana-Farber Cancer Institute, Inc. Method of promoting b-cell proliferation and activation with CD40 ligand and cyclosporin
US20070122852A1 (en) 2002-11-13 2007-05-31 Micromet Ag Method for identifying antigen specific b cells
US7695712B2 (en) 2005-04-18 2010-04-13 Actx, Inc. Recovery of tissue function following administration of B cells to injured tissue

Also Published As

Publication number Publication date
US7695712B2 (en) 2010-04-13
US20100266561A1 (en) 2010-10-21
WO2006113647A2 (en) 2006-10-26
EP1877544B1 (de) 2011-12-14
WO2006113647A3 (en) 2007-02-08
JP2008536930A (ja) 2008-09-11
EP1877544A4 (de) 2008-11-26
EP1877544A2 (de) 2008-01-16
JP4659092B2 (ja) 2011-03-30
US8603463B2 (en) 2013-12-10
US20060263339A1 (en) 2006-11-23

Similar Documents

Publication Publication Date Title
ATE537249T1 (de) Wiedergewinnung von gewebefunktion nach verabreichung von b-zellen an verletztes gewebe
BR0308429A (pt) Aroilpiridinonas monocìclicas como agentes antiinflamatórios
BRPI0418251A (pt) fosfonatos, monofosfonamidatos, bisfosfonamidatos para o tratamento de doenças virais
TW200511444A (en) Strained-silicon-on-insulator single-and double-gate MOSFET and method for forming the same
SG149061A1 (en) Definitive endoderm
EA200802213A1 (ru) Способы лечения заболеваний крови
BR0011130A (pt) Inibidores de metaloproteases
WO2004096818A3 (en) Method and compositions for identifying anti-hiv therapeutic compounds
ECSP055584A (es) Proceso para la preparación de fibrinógeno
MY151020A (en) Transdermal therapeutic system
TW200606177A (en) Glycoprotein VI antibodies and methods thereof
WO2005042516A3 (en) Ligands of melanocortin receptors and compositions and methods related thereto
MA28707B1 (fr) Utilisation de 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines substituees lors du traitement de nausees et de vomissements
BRPI0311189B8 (pt) composições farmacêuticas contendo polimorfo a de flibanserin, bem como seu uso
IS2613B (is) Útskipt díketópíperasín sem oxýtósínblokkar
WO2006076504A3 (en) Sialic acid permease system
HK1121670A1 (en) Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
DK1240326T3 (da) Udlösende receptor der er involveret i naturlig cytotoxicitet medieret af humane naturlige dræberceller og antistoffer som identificerer denne receptor
CY1109803T1 (el) Φαρμακευτικες συνθεσεις που βασιζονται σε ανταγωνιστες νκ2 για παιδιατρικη χρηση
PL376130A1 (en) Controlled releases system containing temozolomide
DE50309647D1 (de) Ng fibrotischer erkrankungen
ATE377020T1 (de) Kristallines gamma-lacton der17beta-hydroxy-
WO2007092607A3 (en) Treatment of hemorrhagic viral infections using a tissue factor inhibitor
DE602005011029D1 (de) Therapeutisches mittel zur behandlung von plasmazellneoplasien
ATE423780T1 (de) Makrozyclen zur behandlung von krebserkrankungen