EP3914265A4 - B-zell-immuntherapie - Google Patents

B-zell-immuntherapie Download PDF

Info

Publication number
EP3914265A4
EP3914265A4 EP20745872.0A EP20745872A EP3914265A4 EP 3914265 A4 EP3914265 A4 EP 3914265A4 EP 20745872 A EP20745872 A EP 20745872A EP 3914265 A4 EP3914265 A4 EP 3914265A4
Authority
EP
European Patent Office
Prior art keywords
cell immunotherapy
immunotherapy
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20745872.0A
Other languages
English (en)
French (fr)
Other versions
EP3914265A1 (de
Inventor
Mark C. Poznansky
Ruxandra F. SIRBULESCU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Holy Cross Hospital Inc
Original Assignee
General Hospital Corp
Holy Cross Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Holy Cross Hospital Inc filed Critical General Hospital Corp
Priority claimed from PCT/US2020/014836 external-priority patent/WO2020154534A1/en
Publication of EP3914265A1 publication Critical patent/EP3914265A1/de
Publication of EP3914265A4 publication Critical patent/EP3914265A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4612—B-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46432—Nervous system antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP20745872.0A 2019-01-23 2020-01-23 B-zell-immuntherapie Pending EP3914265A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962795629P 2019-01-23 2019-01-23
US201962837765P 2019-04-24 2019-04-24
PCT/US2020/014836 WO2020154534A1 (en) 2019-01-23 2020-01-23 B cell immunotherapy

Publications (2)

Publication Number Publication Date
EP3914265A1 EP3914265A1 (de) 2021-12-01
EP3914265A4 true EP3914265A4 (de) 2023-02-01

Family

ID=78232398

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20745872.0A Pending EP3914265A4 (de) 2019-01-23 2020-01-23 B-zell-immuntherapie

Country Status (2)

Country Link
EP (1) EP3914265A4 (de)
CN (1) CN113677354A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115393351B (zh) * 2022-10-27 2023-01-24 北京大学第三医院（北京大学第三临床医学院） 一种基于朗格汉斯细胞判断角膜免疫状态的方法及装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019178613A1 (en) * 2018-03-16 2019-09-19 Immusoft Corporation B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4988204B2 (ja) * 2004-02-09 2012-08-01 田辺三菱製薬株式会社 筋萎縮性側索硬化症（ａｌｓ）又はａｌｓに起因する疾患の新規治療剤
EP1877544B1 (de) * 2005-04-18 2011-12-14 ACTX, Inc. Wiedergewinnung von gewebefunktion nach verabreichung von b-zellen an verletztes gewebe
US20100028296A1 (en) * 2005-05-02 2010-02-04 Chavez Raymond A Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
WO2009131712A2 (en) * 2008-04-25 2009-10-29 Duke University Medical Center Regulatory b cells and their uses
WO2011147622A1 (en) * 2010-05-26 2011-12-01 Deutsches Rheuma-Forschungszentrum Berlin Antigen-presenting modified naïve b cells for immune suppression and a method for producing said modified cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019178613A1 (en) * 2018-03-16 2019-09-19 Immusoft Corporation B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. RAY ET AL: "A Novel IL-10-Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand", THE JOURNAL OF IMMUNOLOGY, vol. 188, no. 7, 1 April 2012 (2012-04-01), pages 3188 - 3198, XP055034451, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1103354 *
BODHANKAR SHEETAL ET AL: "IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke", METABOLIC BRAIN DISEASE, vol. 28, no. 3, 1 September 2013 (2013-09-01), US, pages 375 - 386, XP055960801, ISSN: 0885-7490, Retrieved from the Internet <URL:https://link.springer.com/content/pdf/10.1007/s11011-013-9413-3.pdf> DOI: 10.1007/s11011-013-9413-3 *
MILO RON ET AL: "Therapies for multiple sclerosis targeting B cells", CROATIAN MEDICAL JOURNAL, vol. 60, no. 2, 1 April 2019 (2019-04-01), CR, pages 87 - 98, XP055960892, ISSN: 0353-9504, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509632/pdf/CroatMedJ_60_0087.pdf> DOI: 10.3325/cmj.2019.60.87 *
PENNATI ANDREA ET AL: "Adoptive transfer of IL-10+regulatory B cells decreases myeloid-derived macrophages in the central nervous system in a transgenic amyotrophic lateral sclerosis model", CELLULAR & MOLECULAR IMMUNOLOGY, NATURE PUBLISHING GROUP UK, LONDON, vol. 15, no. 7, 8 January 2018 (2018-01-08), pages 727 - 730, XP036854777, ISSN: 1672-7681, [retrieved on 20180108], DOI: 10.1038/CMI.2017.152 *
See also references of WO2020154534A1 *

Also Published As

Publication number Publication date
CN113677354A (zh) 2021-11-19
EP3914265A1 (de) 2021-12-01

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DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HOLY CROSS HOSPITAL, INC.

Owner name: THE GENERAL HOSPITAL CORPORATION

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/0781 20100101ALI20220920BHEP

Ipc: A61P 25/28 20060101ALI20220920BHEP

Ipc: A61K 35/12 20150101AFI20220920BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20230105

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/0781 20100101ALI20221223BHEP

Ipc: A61P 25/28 20060101ALI20221223BHEP

Ipc: A61K 35/12 20150101AFI20221223BHEP