ATE533776T1 - Analoge verbindungen analgetischer peptide, abgeleitet vom crotalus durissus terrificus schlangengift, ihre verwendungen, zusammensetzungen und verfahren ihrer herstellung und reinigung - Google Patents

Analoge verbindungen analgetischer peptide, abgeleitet vom crotalus durissus terrificus schlangengift, ihre verwendungen, zusammensetzungen und verfahren ihrer herstellung und reinigung

Info

Publication number
ATE533776T1
ATE533776T1 AT05738454T AT05738454T ATE533776T1 AT E533776 T1 ATE533776 T1 AT E533776T1 AT 05738454 T AT05738454 T AT 05738454T AT 05738454 T AT05738454 T AT 05738454T AT E533776 T1 ATE533776 T1 AT E533776T1
Authority
AT
Austria
Prior art keywords
purification
preparation
methods
compositions
compounds derived
Prior art date
Application number
AT05738454T
Other languages
English (en)
Inventor
Yara Cury
Gisele Picolo
Katsuhiro Konno
Renata Giorgi
Patricia Brigatte
Vanessa Gutierrez
Antonio Camargo
Original Assignee
Laboratorios Biosintetica Ltda
Fundacaeo De Amparo A Pesquisa Do Estado De Saeo Paulo Fapesp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BRPI0502399-8A external-priority patent/BRPI0502399B1/pt
Application filed by Laboratorios Biosintetica Ltda, Fundacaeo De Amparo A Pesquisa Do Estado De Saeo Paulo Fapesp filed Critical Laboratorios Biosintetica Ltda
Application granted granted Critical
Publication of ATE533776T1 publication Critical patent/ATE533776T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
AT05738454T 2004-05-06 2005-05-06 Analoge verbindungen analgetischer peptide, abgeleitet vom crotalus durissus terrificus schlangengift, ihre verwendungen, zusammensetzungen und verfahren ihrer herstellung und reinigung ATE533776T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI0401702 2004-05-06
BRPI0502399-8A BRPI0502399B1 (pt) 2005-05-02 2005-05-02 Compostos análogos a peptídeos analgésicos derivados de veneno de serpentes crotalus durissus terrificus, seus usos, composições, métodos de preparação e de puruficação
PCT/BR2005/000073 WO2005107357A2 (en) 2004-05-06 2005-05-06 Analgesic peptides derived from the venom of crotalus durissus terrificuss snakes

Publications (1)

Publication Number Publication Date
ATE533776T1 true ATE533776T1 (de) 2011-12-15

Family

ID=37625965

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05738454T ATE533776T1 (de) 2004-05-06 2005-05-06 Analoge verbindungen analgetischer peptide, abgeleitet vom crotalus durissus terrificus schlangengift, ihre verwendungen, zusammensetzungen und verfahren ihrer herstellung und reinigung

Country Status (10)

Country Link
US (1) US9109041B2 (de)
EP (1) EP1765851B1 (de)
JP (1) JP4777344B2 (de)
CN (1) CN101048170B (de)
AT (1) ATE533776T1 (de)
AU (1) AU2005239771B2 (de)
CA (1) CA2565731C (de)
ES (1) ES2377635T3 (de)
PT (1) PT1765851E (de)
WO (1) WO2005107357A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101048170B (zh) 2004-05-06 2011-04-13 生物合成实验室有限公司 源自响尾蛇crotalus durissus terrificus蛇毒的止痛肽的类似化合物、它们的用途、组合物、 制备和纯化方法
AU2008243720B2 (en) * 2007-05-01 2012-07-05 Biolab Sanus Farmaceutica Ltda. Analgesic compounds
JP5872673B2 (ja) * 2011-03-28 2016-03-01 エス．アイ．エス． シュロブ イノベイティブ サイエンス リミテッド 皮膚疾患を治療するための方法
BR102014011436A8 (pt) * 2014-05-12 2018-01-09 Univ Estadual Paulista Julio De Mesquita Filho selante de fibrina para uso tópico, método de formação do mesmo e seu uso
BR102014011432B1 (pt) * 2014-05-12 2022-06-07 Universidade Estadual Paulista Julio De Mesquita Filho Arcabouço tridimensional para células tronco, processo de obtenção do mesmo e seu uso
BR102016023153A2 (pt) * 2016-10-04 2018-05-02 Fundação Butantan Composição, uso, e, método para tratar doenças neurodegenerativas
WO2026025169A1 (en) * 2024-08-02 2026-02-05 Instituto Butantan Peptide derived from crotalphine, composition comprising the said peptide, its use and method to treat acute or chronic pain

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1184164B (it) 1985-03-19 1987-10-22 Eniricerche Spa Triptidi ad azione ipotensiva e procedimento per la loro sintesi
DE3784768T2 (de) * 1986-05-19 1993-06-24 Ventech Research Inc Verwendung von zusammensetzungen auf basis von crotoxin, zur herstellung von medikamenten zur behandlung von carcinomen.
US5164196A (en) * 1987-05-19 1992-11-17 Ventech Research, Inc. Crotoxin complex as cytotoxic agent
WO1991001740A1 (en) 1989-08-05 1991-02-21 Varánusz Gm Process for producing pharmacosmetics
US5232911A (en) * 1990-01-03 1993-08-03 Ventech Research Inc. Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent
US5439884A (en) * 1992-07-27 1995-08-08 Oregon Regional Primate Research Center Method of controlling fertilization using bombesin or its agonist
US5866346A (en) * 1995-09-27 1999-02-02 Indiana Unversity Foundation Methods of using dynorphins as ligands for XOR1 receptor
IL123001A (en) 1998-01-20 1998-12-06 Shulov Inst For Venom Research Analgesic fraction from snake March and pharmacy preparations containing it
CN101048170B (zh) * 2004-05-06 2011-04-13 生物合成实验室有限公司 源自响尾蛇crotalus durissus terrificus蛇毒的止痛肽的类似化合物、它们的用途、组合物、 制备和纯化方法
AU2008243720B2 (en) * 2007-05-01 2012-07-05 Biolab Sanus Farmaceutica Ltda. Analgesic compounds

Also Published As

Publication number Publication date
PT1765851E (pt) 2012-01-06
WO2005107357A2 (en) 2005-11-17
CN101048170A (zh) 2007-10-03
AU2005239771A1 (en) 2005-11-17
EP1765851A4 (de) 2008-05-28
ES2377635T3 (es) 2012-03-29
US9109041B2 (en) 2015-08-18
JP2008504234A (ja) 2008-02-14
CA2565731C (en) 2015-07-07
CN101048170B (zh) 2011-04-13
AU2005239771B2 (en) 2011-03-10
CA2565731A1 (en) 2005-11-17
WO2005107357A3 (en) 2007-05-24
US20090203618A1 (en) 2009-08-13
EP1765851A2 (de) 2007-03-28
EP1765851B1 (de) 2011-11-16
JP4777344B2 (ja) 2011-09-21

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