WO2005087809B1 - Peptides from vitronectin and their therapeutic exploitation for osteoblast adhesion - Google Patents
Peptides from vitronectin and their therapeutic exploitation for osteoblast adhesionInfo
- Publication number
- WO2005087809B1 WO2005087809B1 PCT/IT2005/000132 IT2005000132W WO2005087809B1 WO 2005087809 B1 WO2005087809 B1 WO 2005087809B1 IT 2005000132 W IT2005000132 W IT 2005000132W WO 2005087809 B1 WO2005087809 B1 WO 2005087809B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nonapeptide
- accordance
- preparation
- compositions
- osteoblast
- Prior art date
Links
- 210000000963 osteoblast Anatomy 0.000 title claims abstract 8
- 230000000790 osteoblast Effects 0.000 title claims abstract 8
- 102100009661 VTN Human genes 0.000 title claims abstract 4
- 108010031318 Vitronectin Proteins 0.000 title claims abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 230000001225 therapeutic Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000001737 promoting Effects 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003042 antagnostic Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 abstract 1
Abstract
A nonapeptide from human vitronectin, whose primary structure has been determined, which has been proved to have specific and significant properties in the promotion of osteoblast adhesion. Peptides included in this invention can be usefully applied in odontoiatric and orthopaedic fields for those pathologies that require to recover bone tissue integrity (e.g. implantology).
Claims
1. Nonapeptide 351 -359 of human vitronectin of sequence 2 (FRHRNRKGY).
2. Nonapeptide 351-359 in accordance with claim 1, covalently bound to proteins different from vitronectin.
3. Nonapeptide 351-359 in accordance with claims 1-2 that contains amino acids of D- configuration.
4. Nonapeptide 351-359 in accordance with claims 1-3 covalently bound to carrier molecules.
5. Use of nonapeptide 351-359 in accordance with claims 1-4 for the preparation of composition aimed at promoting osteoblast adhesion.
6. Use of nonapeptide 351 -359 in accordance with claims 1 -4 for the preparation of composition aimed at treating odontoiatric pathologies.
7. Use of nonapeptide 351-359 in accordance with claims 1-4 for the preparation of composition aimed at treating orthopaedic pathologies.
8. Use of nonapeptide 351-359 in accordance with claims 1-4 for the preparation of composition for implantology.
9. Compositions having as active principle nonapeptide 351-359 in accordance with claims 1-4 for the use in promoting osteoblast adhesion.
10. Compositions having as active principle nonapeptide 351-359 in accordance with claims 1-4 for the use in treating odontoiatric pathologies.
11. Compositions having as active principle nonapeptide 351-359 in accordance with claims 1-4 for the use in treating orthopaedic pathologies.
12. Compositions having as active principle nonapeptide 351-359 in accordance with claims 1-4 for the use in implantology.
13. Procedure for the identification and selection of agonists and/or antagonists of nonapeptide 351-359 in accordance with claims 1-4 based on: a) addition of the above mentioned nonapeptide to osteoblast cultures and verification of promotion or inhibition of osteoblast adhesion; b) addition of the above mentioned compositions to osteoblast cultures and verification of osteoblast adhesion promotion or inhibition.
14. Procedure in accordance with claim 13 where steps a) and b) can be performed following a different chronological order.
15. Process for the preparation of nonapeptide 351-359 in accordance with claims 1-4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD2004A000065 | 2004-03-15 | ||
| ITPD20040065 ITPD20040065A1 (en) | 2004-03-15 | 2004-03-15 | PEPTIDES OF VITRONECTIN AND THEIR THERAPEUTIC USE IN THE MEMBERSHIP OF OSTEOBLASTS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2005087809A2 WO2005087809A2 (en) | 2005-09-22 |
| WO2005087809A3 WO2005087809A3 (en) | 2005-11-17 |
| WO2005087809B1 true WO2005087809B1 (en) | 2006-02-02 |
Family
ID=34976295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IT2005/000132 WO2005087809A2 (en) | 2004-03-15 | 2005-03-11 | Peptides from vitronectin and their therapeutic exploitation for osteoblast adhesion |
Country Status (2)
| Country | Link |
|---|---|
| IT (1) | ITPD20040065A1 (en) |
| WO (1) | WO2005087809A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016204545A1 (en) * | 2015-06-18 | 2016-12-22 | 서울대학교 산학협력단 | Peptide for promoting osteogenesis or inhibiting osteolysis, and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE56509B1 (en) * | 1982-11-04 | 1991-08-28 | Univ California | Methods for oncogenic detection |
| WO2003023401A1 (en) * | 2001-09-12 | 2003-03-20 | Eidgenössische Technische Hochschule Zürich | Device with chemical surface patterns |
-
2004
- 2004-03-15 IT ITPD20040065 patent/ITPD20040065A1/en unknown
-
2005
- 2005-03-11 WO PCT/IT2005/000132 patent/WO2005087809A2/en active Application Filing
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