ATE533041T1 - Verfahren zur analyse einer probe und vorrichtung dafür - Google Patents

Verfahren zur analyse einer probe und vorrichtung dafür

Info

Publication number
ATE533041T1
ATE533041T1 AT05768147T AT05768147T ATE533041T1 AT E533041 T1 ATE533041 T1 AT E533041T1 AT 05768147 T AT05768147 T AT 05768147T AT 05768147 T AT05768147 T AT 05768147T AT E533041 T1 ATE533041 T1 AT E533041T1
Authority
AT
Austria
Prior art keywords
sample
response
processing means
experiment
analyzing
Prior art date
Application number
AT05768147T
Other languages
English (en)
Inventor
Colin Blackmore
Patrick Courtney
Alistair Fitch
Shab Ladha
Original Assignee
Perkinelmer Singapore Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkinelmer Singapore Pte Ltd filed Critical Perkinelmer Singapore Pte Ltd
Priority claimed from PCT/GB2005/003226 external-priority patent/WO2006024819A2/en
Application granted granted Critical
Publication of ATE533041T1 publication Critical patent/ATE533041T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6432—Quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT05768147T 2004-09-01 2005-08-17 Verfahren zur analyse einer probe und vorrichtung dafür ATE533041T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0419325.6A GB0419325D0 (en) 2004-09-01 2004-09-01 A method of analysing a sample including fluorescent labels and apparatus therefor
GB0512811A GB2418018B (en) 2004-09-01 2005-06-23 A method of analysing a sample including fluorescent labels and apparatus therefor
PCT/GB2005/003226 WO2006024819A2 (en) 2004-09-01 2005-08-17 A method of analysing a sample and apparatus therefor

Publications (1)

Publication Number Publication Date
ATE533041T1 true ATE533041T1 (de) 2011-11-15

Family

ID=33104852

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05768147T ATE533041T1 (de) 2004-09-01 2005-08-17 Verfahren zur analyse einer probe und vorrichtung dafür

Country Status (4)

Country Link
US (1) US7671345B2 (de)
EP (1) EP2375240B1 (de)
AT (1) ATE533041T1 (de)
GB (2) GB0419325D0 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0900526D0 (en) 2009-01-14 2009-02-11 Perkinelmer Ltd Fluorescence microscopy methods and apparatus
US8759792B2 (en) * 2009-07-10 2014-06-24 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Non-contact total emission detection method and system for multi-photon microscopy
WO2012096619A1 (en) * 2011-01-12 2012-07-19 Applied Precision, Inc. Systems and methods for camera-based image processing in microscopy instruments
US9733156B2 (en) 2012-10-29 2017-08-15 Perkinelmer Health Sciences, Inc. Sample platforms and methods of using them
US9412572B2 (en) 2012-10-28 2016-08-09 Perkinelmer Health Sciences, Inc. Sample holders and methods of using them
US9117641B2 (en) 2012-10-29 2015-08-25 Perkinelmer Health Sciences, Inc. Direct sample analysis device adapters and methods of using them
US10597697B2 (en) * 2015-02-05 2020-03-24 Ge Healthcare Bio-Sciences Corp. Method of determining a nucleotide sequence of a nucleic acid segment from a region of interest in a biological sample
DE102015118856B3 (de) * 2015-11-04 2016-08-18 Netzsch-Gerätebau GmbH Verfahren und Vorrichtung zur photothermischen Untersuchung einer Probe
JP6583442B2 (ja) * 2016-02-19 2019-10-02 株式会社ニコン 試料作製方法および試料作製装置
DE102016109303A1 (de) * 2016-05-20 2017-11-23 Friedrich-Schiller-Universität Jena Lasermikroskop mit Ablationsfunktion
WO2018044919A1 (en) 2016-09-01 2018-03-08 The George Washington University Enzyme-dependent fluorescence recovery of nadh after photobleaching to assess dehydrogenase activity of living tissues
GB201707239D0 (en) * 2017-05-05 2017-06-21 Univ Edinburgh Optical system and method

Family Cites Families (20)

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US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
JPH0660901B2 (ja) * 1985-08-30 1994-08-10 東ソー株式会社 酵素免疫測定法
US4895156A (en) * 1986-07-02 1990-01-23 Schulze John E Sensor system using fluorometric decay measurements
FR2671405B1 (fr) * 1991-01-04 1994-07-08 Inst Nat Sante Rech Med Dispositif de mesure du ph d'une cible, procede d'utilisation dudit dispositif et ses applications.
EP0519066A4 (en) * 1991-01-04 1993-08-18 Baxter Diagnostics Inc. Measurement of bacterial co 2? production in an isolated fluorophore by monitoring an absorbance regulated change of fluorescence
CA2133643A1 (en) * 1992-04-06 1993-10-14 Stanley R. Bouma Method and device for detection of nucleic acid or analyte using total internal reflectance
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
JP4281877B2 (ja) * 1996-06-04 2009-06-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション 生物学的プロセスを実行し且つモニタリングするためのシステムと方法
US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6289229B1 (en) * 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
AU5223899A (en) * 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
WO2000064988A1 (en) * 1999-04-23 2000-11-02 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US20030026762A1 (en) * 1999-05-05 2003-02-06 Malmros Mark K. Bio-spectral imaging system and methods for diagnosing cell disease state
EP1252236A1 (de) * 2000-02-02 2002-10-30 Amersham Pharmacia Biotech UK Limited Messreagenz
ES2203365T3 (es) * 2000-04-06 2004-04-16 European Molecular Biology Laboratory Microscopio controlado por ordenador.
US6678398B2 (en) * 2000-09-18 2004-01-13 Sti Medical Systems, Inc. Dual mode real-time screening and rapid full-area, selective-spectral, remote imaging and analysis device and process
CN1348096A (zh) * 2000-10-10 2002-05-08 栾国彦 一种均相特异性检测核酸的探针及应用方法
US20020048811A1 (en) * 2000-10-16 2002-04-25 Devreotes Peter N. Receptor mediated activation of heterotrimeric G-proteins
DE10155053B4 (de) * 2001-11-09 2005-11-24 Friz Biochem Gesellschaft Für Bioanalytik Mbh Reversible Bindung eines Fluorophors an eine Oberfläche zur Detektion von Ligat-Ligand-Assoziationsereignissen durch Fluoreszenz-Quenchen
CA2429101A1 (en) * 2002-10-24 2004-04-24 Ben Gao Method and equipment to monitor nucleic acid hybridization on a dna chip using four-dimensional parameters

Also Published As

Publication number Publication date
GB0512811D0 (en) 2005-08-03
GB0419325D0 (en) 2004-09-29
US7671345B2 (en) 2010-03-02
EP2375240B1 (de) 2013-04-24
GB2418018A (en) 2006-03-15
EP2375240A1 (de) 2011-10-12
US20080315119A1 (en) 2008-12-25
GB2418018B (en) 2007-09-12

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