ATE530243T1 - Verfahren zur herstellung einer immobilisierten mehrschichtigen künstlichen lipidmembran für permeabilitätsmessungen mit der pampa-methode - Google Patents

Verfahren zur herstellung einer immobilisierten mehrschichtigen künstlichen lipidmembran für permeabilitätsmessungen mit der pampa-methode

Info

Publication number
ATE530243T1
ATE530243T1 AT06022376T AT06022376T ATE530243T1 AT E530243 T1 ATE530243 T1 AT E530243T1 AT 06022376 T AT06022376 T AT 06022376T AT 06022376 T AT06022376 T AT 06022376T AT E530243 T1 ATE530243 T1 AT E530243T1
Authority
AT
Austria
Prior art keywords
pampa
producing
subject invention
lipid membrane
artificial lipid
Prior art date
Application number
AT06022376T
Other languages
English (en)
Inventor
Xiaoxi Kevin Chen
Charles L Crespi
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of ATE530243T1 publication Critical patent/ATE530243T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/38—Liquid-membrane separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
    • B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/50—Polycarbonates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/74—Natural macromolecular material or derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
    • B01D71/82—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74 characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/082—Investigating permeability by forcing a fluid through a sample
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/04—Hydrophobization
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4005—Concentrating samples by transferring a selected component through a membrane
    • G01N2001/4016—Concentrating samples by transferring a selected component through a membrane being a selective membrane, e.g. dialysis or osmosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/084—Testing filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/086—Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Water Supply & Treatment (AREA)
  • Manufacturing & Machinery (AREA)
  • Molecular Biology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT06022376T 2005-10-27 2006-10-26 Verfahren zur herstellung einer immobilisierten mehrschichtigen künstlichen lipidmembran für permeabilitätsmessungen mit der pampa-methode ATE530243T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73057005P 2005-10-27 2005-10-27
US11/552,606 US8986781B2 (en) 2005-10-27 2006-10-25 Immobilized multi-layer artificial membrane for permeability measurements (PAMPA)

Publications (1)

Publication Number Publication Date
ATE530243T1 true ATE530243T1 (de) 2011-11-15

Family

ID=37763936

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06022376T ATE530243T1 (de) 2005-10-27 2006-10-26 Verfahren zur herstellung einer immobilisierten mehrschichtigen künstlichen lipidmembran für permeabilitätsmessungen mit der pampa-methode

Country Status (6)

Country Link
US (2) US8986781B2 (de)
EP (1) EP1779921B1 (de)
JP (1) JP4980692B2 (de)
AT (1) ATE530243T1 (de)
AU (1) AU2006233202B2 (de)
CA (1) CA2565726C (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008217579A1 (en) 2007-02-20 2008-08-28 Oxford Nanopore Technologies Limited Formation of lipid bilayers
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
JP5533384B2 (ja) * 2010-03-10 2014-06-25 セイコーエプソン株式会社 電気泳動粒子を含む分散液を封入する封入方法
CN102179188B (zh) * 2011-03-24 2013-04-10 北京工业大学 一种聚偏氟乙烯疏水膜的超疏水化改性方法
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
WO2015177811A2 (en) * 2014-05-23 2015-11-26 Indian Institute Of Technology Madras System and method for measuring permeability of drugs/toxic/ chemical compounds
KR101667907B1 (ko) * 2014-05-29 2016-10-28 지세다이 가가쿠자이료효카 기쥬츠겡큐구미아이 수증기 투과도 측정 장치의 교정용 표준 필름 및 그 제조 방법, 및 교정용 표준 필름 세트 및 그것을 이용한 교정 방법
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
WO2016078667A1 (en) * 2014-11-17 2016-05-26 Syddansk Universitet Assembly for assessing drug permeability with adjustable biomimetic properties
US10996158B2 (en) * 2016-06-22 2021-05-04 Nanyang Technological University Method and arrangement for determining at least one pore-related parameter of a porous structure
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
US11293911B2 (en) 2017-12-28 2022-04-05 Korea Advanced Institute Of Science And Technology Multi-phase liquid composition, device for measuring permeability of drugs, and method for measuring permeability of drugs
CN113574381A (zh) 2019-03-12 2021-10-29 牛津纳米孔科技公司 纳米孔感测装置、组件和操作方法

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SE8405611D0 (sv) * 1984-11-09 1984-11-09 Astra Laekemedel Ab Process for stabilization of bacampicillin hydrochloride
JPS63141609A (ja) * 1986-12-03 1988-06-14 Terumo Corp 親水性多孔質膜およびその製造方法
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5177064A (en) * 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
GB9112267D0 (en) * 1991-06-07 1991-07-24 Biocompatibles Ltd Polymeric coating
AU2001239564A1 (en) * 2000-03-23 2001-10-03 Chugai Seiyaku Kabushiki Kaisha Lipid membrane, method for measuring membrane permeability, and method for screening
IL145106A0 (en) * 2000-08-30 2002-06-30 Pfizer Prod Inc Intermittent administration of a geowth hormone secretagogue
EP1232792B1 (de) 2001-02-20 2006-09-06 F. Hoffmann-La Roche Ag Lineare Küvettenmatrix, damit gebaute zweidimensionale Küvettenmatrix und solche zweidimensionale Küvettenmatrizen umfassendes System
EP1399539A2 (de) * 2001-06-29 2004-03-24 Wyeth Verfahren und zusammensetzung zur vorhersage der permeabilität der blut-hirn-schranke
US6863833B1 (en) * 2001-06-29 2005-03-08 The Board Of Trustees Of The Leland Stanford Junior University Microfabricated apertures for supporting bilayer lipid membranes
US7060428B2 (en) 2001-06-29 2006-06-13 Wyeth Methods and compositions useful for the prediction of blood-brain barrier permeation
DE60330669D1 (de) 2002-01-31 2010-02-04 Pion Inc Verfahren und vorrichtung zur messung der membranpermeabilität
JP4057534B2 (ja) * 2002-02-14 2008-03-05 ミリポア・コーポレイション 希釈剤の製造方法および使用
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Also Published As

Publication number Publication date
US8986781B2 (en) 2015-03-24
US9999859B2 (en) 2018-06-19
CA2565726C (en) 2015-08-11
EP1779921B1 (de) 2011-10-26
AU2006233202B2 (en) 2011-04-21
EP1779921A1 (de) 2007-05-02
JP4980692B2 (ja) 2012-07-18
JP2007118003A (ja) 2007-05-17
AU2006233202A1 (en) 2007-05-17
US20150144552A1 (en) 2015-05-28
US20070181490A1 (en) 2007-08-09
CA2565726A1 (en) 2007-04-27

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