ATE527350T1 - Verfahren und zusammensetzungen zur behandlung, hemmung und reversierung von bandscheibenerkrankungen - Google Patents
Verfahren und zusammensetzungen zur behandlung, hemmung und reversierung von bandscheibenerkrankungenInfo
- Publication number
- ATE527350T1 ATE527350T1 AT06733663T AT06733663T ATE527350T1 AT E527350 T1 ATE527350 T1 AT E527350T1 AT 06733663 T AT06733663 T AT 06733663T AT 06733663 T AT06733663 T AT 06733663T AT E527350 T1 ATE527350 T1 AT E527350T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- inhibiting
- treating
- reversing disc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/033,466 US7585848B2 (en) | 2005-01-11 | 2005-01-11 | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
PCT/US2006/000788 WO2006086105A2 (en) | 2005-01-11 | 2006-01-11 | Methods and compositions for treating intervertebral disc disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE527350T1 true ATE527350T1 (de) | 2011-10-15 |
Family
ID=36653486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06733663T ATE527350T1 (de) | 2005-01-11 | 2006-01-11 | Verfahren und zusammensetzungen zur behandlung, hemmung und reversierung von bandscheibenerkrankungen |
Country Status (7)
Country | Link |
---|---|
US (1) | US7585848B2 (de) |
EP (1) | EP1841463B1 (de) |
JP (2) | JP4913072B2 (de) |
AT (1) | ATE527350T1 (de) |
CA (1) | CA2594349C (de) |
ES (1) | ES2374440T3 (de) |
WO (1) | WO2006086105A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1340505A3 (de) * | 1993-10-29 | 2004-07-14 | The Brigham And Women's Hospital, Inc. | Therapeutische Verwendung von cis-Element-Fallen in vivo |
DE60142899D1 (de) * | 2000-06-20 | 2010-10-07 | Dainippon Sumitomo Pharma Co | Verbindungen für den transfer von oligonukleotiden |
EP1407787B1 (de) * | 2001-06-20 | 2009-04-29 | Dainippon Sumitomo Pharma Co., Ltd. | Verfahren zur förderung des nukleinsäuretransfers |
US7378509B2 (en) * | 2003-12-02 | 2008-05-27 | Anesiva, Inc. | NF-kappaB oligonucleotide decoy molecules |
EP1799271A4 (de) * | 2004-09-21 | 2010-05-05 | Anesiva Inc | Abgabe von polynucleotiden |
US7585848B2 (en) * | 2005-01-11 | 2009-09-08 | Rush University Medical Center | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
US20100196509A1 (en) | 2005-02-28 | 2010-08-05 | Jonathan Braun | Methods for Diagnosis and Treatment of Endometrial Cancer |
WO2006113526A2 (en) | 2005-04-15 | 2006-10-26 | The Regents Of The University Of California | Prevention of chlamydia infection using a protective antibody |
US8318906B2 (en) | 2005-04-15 | 2012-11-27 | The Regents Of The University Of California | EMP2 antibodies and their therapeutic uses |
US8648052B2 (en) * | 2005-04-15 | 2014-02-11 | The Regents Of The University Of California | Prevention of chlamydia infection using SIRNA |
EP3199635B1 (de) * | 2007-05-11 | 2019-02-06 | Adynxx, Inc. | Genexpression und schmerzen |
US9464135B2 (en) | 2007-10-08 | 2016-10-11 | The Regents Of The University Of California | Epithelial membrane protein-2 (EMP2) and proliferative vitroretinopathy (PVR) |
WO2010079811A1 (ja) * | 2009-01-07 | 2010-07-15 | 学校法人久留米大学 | 椎間板変性関連疾患感受性遺伝子およびその用途 |
EP2846839B1 (de) | 2012-05-10 | 2019-02-20 | Adynxx, Inc. | Formulierungen zur abgabe von wirkstoffen |
JP6705807B2 (ja) | 2014-08-15 | 2020-06-03 | エーダイニクス インコーポレイテッド | 疼痛を治療するためのオリゴヌクレオチドデコイ |
CN105255862B (zh) * | 2014-12-30 | 2018-05-22 | 南京艾德凯腾生物医药有限责任公司 | 一种用于制备抑制肿瘤生长药物的寡聚核酸及其应用 |
SE1550338A1 (en) * | 2015-03-20 | 2016-09-21 | Stayble Therapeutics Ab | A composition for use in the treatment of intervertebral misalignment |
US20200017853A1 (en) * | 2016-02-29 | 2020-01-16 | Adynxx, Inc. | Compositions and methods for pain amelioration via modification of gene expression |
CN113453695A (zh) * | 2018-12-24 | 2021-09-28 | 加州大学评议会 | 用嵌合体诱饵治疗脊柱病症 |
CN110585423A (zh) * | 2019-10-24 | 2019-12-20 | 内蒙古医科大学第二附属医院 | Il-6在制备治疗腰椎间盘突出药物中的应用 |
CN110613837A (zh) * | 2019-10-24 | 2019-12-27 | 内蒙古医科大学第二附属医院 | TGF-β在制备预防或治疗腰椎间盘突出药物中的应用 |
US20230069350A1 (en) * | 2020-01-15 | 2023-03-02 | The Regents Of The University Of California | Methods and compositions relating to prolonged inflammatory inhibition and/or prolonged treatment of spinal pain by chimera decoy |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410516B1 (en) * | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
EP0584238A1 (de) | 1991-05-17 | 1994-03-02 | Chiron Corporation | Inhibitor von nf-kb transkriptions-aktivator und seine verwendungen |
CA2105595A1 (en) | 1992-09-23 | 1994-03-24 | Ramaswamy Narayanan | Antisense polynucleotides |
CA2131587A1 (en) | 1993-09-07 | 1995-03-08 | Yinon Ben-Neriah | Method for regulation of nf-kb |
EP0652290A1 (de) | 1993-09-07 | 1995-05-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methode zur Regulierung von NF-kappa B |
EP1340505A3 (de) | 1993-10-29 | 2004-07-14 | The Brigham And Women's Hospital, Inc. | Therapeutische Verwendung von cis-Element-Fallen in vivo |
US6399376B1 (en) | 1993-11-05 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Modulation of vascular cell adhesive molecule expression through oligonucleotide interactions |
EP0824918B1 (de) | 1995-05-12 | 2007-03-28 | AnGes MG, Inc. | HEILUNG UND VORBEUGUNG VON DURCH NF-kappaB VERURSACHTEN ERKRANKUNGEN |
US20010006948A1 (en) * | 1998-11-25 | 2001-07-05 | James D. Kang | Gene transfer to intervertebral disc cells |
US20030113796A1 (en) * | 2000-01-27 | 2003-06-19 | Sims John E. | FIL-1 theta DNAs and polypeptides |
DE60231063D1 (de) * | 2002-02-01 | 2009-03-19 | Anges Mg Inc | N zur behandlung von aneurysmen |
JPWO2003099339A1 (ja) * | 2002-05-29 | 2005-09-22 | アンジェスMg株式会社 | 炎症性疾患を処置および予防するためのデコイ組成物 |
US7585848B2 (en) * | 2005-01-11 | 2009-09-08 | Rush University Medical Center | Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc |
-
2005
- 2005-01-11 US US11/033,466 patent/US7585848B2/en active Active
-
2006
- 2006-01-11 WO PCT/US2006/000788 patent/WO2006086105A2/en active Application Filing
- 2006-01-11 ES ES06733663T patent/ES2374440T3/es active Active
- 2006-01-11 JP JP2007551318A patent/JP4913072B2/ja active Active
- 2006-01-11 EP EP06733663A patent/EP1841463B1/de active Active
- 2006-01-11 AT AT06733663T patent/ATE527350T1/de not_active IP Right Cessation
- 2006-01-11 CA CA2594349A patent/CA2594349C/en active Active
-
2011
- 2011-11-02 JP JP2011241717A patent/JP2012092104A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2594349C (en) | 2012-05-29 |
JP4913072B2 (ja) | 2012-04-11 |
ES2374440T3 (es) | 2012-02-16 |
US7585848B2 (en) | 2009-09-08 |
US20060153847A1 (en) | 2006-07-13 |
JP2008526968A (ja) | 2008-07-24 |
EP1841463A4 (de) | 2008-08-27 |
EP1841463B1 (de) | 2011-10-05 |
JP2012092104A (ja) | 2012-05-17 |
EP1841463A2 (de) | 2007-10-10 |
WO2006086105A3 (en) | 2007-10-25 |
CA2594349A1 (en) | 2006-08-17 |
WO2006086105A2 (en) | 2006-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE527350T1 (de) | Verfahren und zusammensetzungen zur behandlung, hemmung und reversierung von bandscheibenerkrankungen | |
NL301145I2 (nl) | Tirbanibulin | |
NO20072558L (no) | Mitotiske kineseinhibitorer og fremgangsmater for anvendelse derav | |
WO2005117846A3 (en) | Ice inhibitors for the treatment of autoinflammatory diseases | |
NO20061197L (no) | Proteasominhibitorer og fremgangsmater for anvendelse av samme | |
DK1846424T3 (da) | Proteasom-inhibitorer og fremgangsmåder til anvendelse deraf | |
DE602004017736D1 (de) | Verwendung von rapamycin und dessen derivaten zur behandlung von knochenverlust | |
TW200716673A (en) | Use of TNF &ahr; inhibitor for treatment of erosive polyarthritis | |
WO2006105304A3 (en) | Phenyl and pyridyl lta4h modulators | |
EA200900571A1 (ru) | Композиции chk1 ингибиторов | |
ATE423087T1 (de) | Proteasome inhibitoren und deren verwendung | |
ATE548035T1 (de) | Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat | |
NO20076186L (no) | Mitotiske kinesininhibitorer og fremgangsmater for anvendelse derav | |
BRPI0607985A2 (pt) | modulador da dscr1, métodos de tratamento, método de melhoria de efeitos colaterais e método de inibição do crescimento de tumores | |
WO2007044325A3 (en) | Apoe4 domain interaction inhibitors and methods of use thereof | |
EA200970164A1 (ru) | Ингибиторы каспазы на основе пиридазинонового каркаса | |
RS54185B1 (en) | USE OF 24-ORDER | |
TW200716561A (en) | P38 inhibitors and methods of use thereof | |
ATE423129T1 (de) | Inhibitoren von lyn-verbundener signaltransduktion (last) und deren verwendung zur behandlung von prostatakrebs | |
DE602004022423D1 (de) | Hemmung der s6-kinase-aktivität zur behandlung von insulinresistenz | |
DE60137506D1 (de) | Verwendung von polysulfatierten cyclodextrinen zur behandlung von arthrose | |
DE60327793D1 (de) | Modulation der s6-kinaseaktivität zur behandlung von adipositas | |
ATE438403T1 (de) | Verwendung eines pde5-hemmers zur behandlung und vorbeugung von hypopigmentierungsstörungen | |
ATE497767T1 (de) | Verfahren zur behandlung von entzündungserkrankungen | |
DK1768948T3 (da) | Substituerede aminoforbindelser som hæmmere af optag af 5-HT/NA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |