ATE524179T1 - Verwendung von quartären pyridiniumsalzen als gefässschutzmittel - Google Patents
Verwendung von quartären pyridiniumsalzen als gefässschutzmittelInfo
- Publication number
- ATE524179T1 ATE524179T1 AT05726215T AT05726215T ATE524179T1 AT E524179 T1 ATE524179 T1 AT E524179T1 AT 05726215 T AT05726215 T AT 05726215T AT 05726215 T AT05726215 T AT 05726215T AT E524179 T1 ATE524179 T1 AT E524179T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridinium salts
- protection agents
- vascular protection
- quarternary
- quarternary pyridinium
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
- 239000011814 protection agent Substances 0.000 title 1
- 230000009441 vascular protection Effects 0.000 title 1
- 101710129448 Glucose-6-phosphate isomerase 2 Proteins 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 210000003989 endothelium vascular Anatomy 0.000 abstract 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 abstract 1
- 229960001123 epoprostenol Drugs 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002666 vasoprotective effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL04364348A PL364348A1 (en) | 2004-01-12 | 2004-01-12 | Application of quaternary pyridine salts as vessel protection agent |
| PCT/EP2005/050057 WO2005067927A2 (en) | 2004-01-12 | 2005-01-07 | The use of quaternary pyridinium salts as vasoprotective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524179T1 true ATE524179T1 (de) | 2011-09-15 |
Family
ID=34793495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05726215T ATE524179T1 (de) | 2004-01-12 | 2005-01-07 | Verwendung von quartären pyridiniumsalzen als gefässschutzmittel |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US7935717B2 (https=) |
| EP (2) | EP2279738A1 (https=) |
| JP (2) | JP5052138B2 (https=) |
| CN (1) | CN1905875B (https=) |
| AT (1) | ATE524179T1 (https=) |
| AU (1) | AU2005205066C1 (https=) |
| CA (1) | CA2547234C (https=) |
| DK (1) | DK1713480T3 (https=) |
| ES (1) | ES2372756T3 (https=) |
| PL (2) | PL364348A1 (https=) |
| PT (1) | PT1713480E (https=) |
| RU (1) | RU2366420C2 (https=) |
| WO (1) | WO2005067927A2 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL364348A1 (en) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| AU2006329564A1 (en) | 2005-07-11 | 2007-07-05 | Pharmena North America Inc. | Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative |
| EP1963270B1 (en) * | 2005-12-09 | 2009-08-05 | Cerecon AG | Quaternary 3 -amido, n-methylpyridinium salts as anti -inflammatory agents |
| PT2026651E (pt) | 2006-03-08 | 2013-06-04 | Cortria Corp | Terapia combinada com inibidores cox não selectivos para prevenir lesões gástricas relacionadas com a cox |
| JP2010506900A (ja) * | 2006-10-18 | 2010-03-04 | デルメナ | リポ蛋白質異常症並びに皮膚疾病および皮膚障害の処置のためのｎ−メチルニコチンアミドを含有する食品抽出物 |
| PL381862A1 (pl) * | 2007-02-28 | 2008-09-01 | Trigendo Spółka Z Ograniczoną Odpowiedzialnością | Zastosowanie związków pirydyniowych i sposób leczenia |
| US20090118225A1 (en) * | 2007-09-28 | 2009-05-07 | Cortria Corporation | 1-Methyl Nicotinamide and Derivatives for Treatment of Gastric Injury |
| EP2211857B1 (en) * | 2007-10-12 | 2012-09-12 | Politechnika Lodzka | Use of quaternary pyridinium salts for radioprotection |
| US8304439B1 (en) | 2007-10-12 | 2012-11-06 | Politechnika Lodzka | Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage |
| PL2211858T3 (pl) | 2007-10-12 | 2015-06-30 | Politechnika Lodzka | Zastosowanie czwartorzędowych soli pirydyniowych do hamowania przerzutów nowotworowych |
| EP2285379A4 (en) * | 2008-05-06 | 2011-11-02 | Cortria Corp | ANALOGUES OF 1-METHYLNICOTINAMIDE |
| CA2764739A1 (en) * | 2008-07-01 | 2010-01-07 | Politechnika Lodzka | N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases |
| US8575175B2 (en) | 2008-07-23 | 2013-11-05 | Toray Industries, Inc. | Therapeutic agent for chronic renal failure |
| EP2186419A1 (en) * | 2008-11-13 | 2010-05-19 | Tchibo GmbH | NMP-containing extract, a method of its production and uses thereof |
| RU2425672C1 (ru) * | 2010-04-12 | 2011-08-10 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гипергомоцистеин-индуцированной эндотелиальной дисфункции смесью растворов гомеопатических разведений поликлональных кроличьих антител к эндотелиальной синтазе оксида азота человека - с12, с30, с200 |
| KR101309576B1 (ko) * | 2011-05-25 | 2013-09-17 | 연세대학교 산학협력단 | 대사물질을 이용한 심부전 바이오마커 |
| PL226999B1 (pl) * | 2013-06-11 | 2017-10-31 | Univ Jagiellonski | Azotan (III) 3 -karbamoilo -1-metylopirydyniowy, sposób jego otrzymywania izastosowanie |
| CN105771005A (zh) * | 2016-03-24 | 2016-07-20 | 乐普（北京）医疗器械股份有限公司 | 一种抗风湿性血管狭窄药物支架及其制备方法和应用 |
| WO2018015862A1 (en) | 2016-07-18 | 2018-01-25 | Pharmena S.A. | 1-methylnicotinamide salts for use in raising the blood levels of adiponectin |
| DK3484475T3 (da) * | 2016-07-18 | 2023-11-27 | Pharmena S A | 1-methylnicotinamid til behandlingen af kardiovaskulær sygdom |
| ES2998765T3 (en) * | 2017-07-27 | 2025-02-21 | Univ Michigan Regents | Plasminogen activator inhibitor-1 (pai-1) inhibitor and method of use |
| PL238932B1 (pl) * | 2017-12-31 | 2021-10-18 | Univ Jagiellonski | Pochodne soli pirydyniowych oraz ich zastosowanie |
| US10864207B2 (en) * | 2019-01-02 | 2020-12-15 | Celagenex Research (India) Pvt. Ltd. | Method of treating endothelial dysfunction |
| WO2021205341A1 (en) | 2020-04-07 | 2021-10-14 | Pharmena S.A. | 1-methylnicotinamide for the prevention/treatment of inflammatory airway diseases |
| WO2022061234A2 (en) * | 2020-09-21 | 2022-03-24 | The Regents Of The University Of California | Immunological effects of metabolites |
| CN115837023B (zh) * | 2023-02-20 | 2023-05-16 | 中山大学附属第八医院（深圳福田） | 1-甲基烟酰胺在制备抗血管钙化药物中的应用 |
| PL248942B1 (pl) * | 2024-01-31 | 2026-02-16 | Politechnika Poznanska | Czwartorzędowe sole amoniowe zawierające anion 2-furanokarboksylanowy i kation będący alkilową pochodną nikotynamidu, sposób ich otrzymywania i zastosowanie jako środki myjąco-dezynfekujące |
| PL447656A1 (pl) * | 2024-01-31 | 2025-08-04 | Politechnika Poznańska | Nowe czwartorzędowe sole amoniowe zawierające anion pochodzący od kwasu nikotynowego oraz kation N-alkilonikotynamidowy, sposób ich otrzymywania oraz zastosowanie jako substancje o aktywności przeciwbakteryjnej |
| PL449092A1 (pl) * | 2024-07-01 | 2026-01-05 | Uniwersytet Jagielloński | Synergiczna kombinacja 1-metylonikotynamidu (MNA) i witaminy K do zastosowania w leczeniu lub zapobieganiu powikłaniom sercowo-naczyniowym terapii przeciwnowotworowych |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB675430A (en) | 1949-07-12 | 1952-07-09 | Cilag Ltd | Novel quaternary nicotinic acid amide derivatives and production thereof |
| DE840698C (de) * | 1949-07-12 | 1952-06-05 | Cilag Aktiengesellschaft | Verfahren zur herstellung neuer derivate des nicotinsaureamids |
| US5260305A (en) | 1988-12-12 | 1993-11-09 | E. R. Squibb & Sons, Inc. | Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US20060263428A1 (en) | 1993-09-20 | 2006-11-23 | Eugenio Cefali | Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics |
| US6406715B1 (en) | 1993-09-20 | 2002-06-18 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique urinary metabolite profiles |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US20030157153A1 (en) | 1997-03-06 | 2003-08-21 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
| US6469035B1 (en) | 1997-07-31 | 2002-10-22 | Eugenio A. Cefali | Methods of pretreating hyperlipidemic individuals with a flush inhibiting agent prior to the start of single daily dose nicotinic acid therapy to reduce flushing provoked by nicotinic acid |
| IE970731A1 (en) | 1997-10-07 | 2000-10-04 | Fuisz Internat Ltd | Product and method for the treatment of hyperlipidemia |
| PL190755B1 (pl) | 1999-01-07 | 2006-01-31 | Pharmena Sp Z Oo | Preparat do leczenia i profilaktyki chorób skóry |
| JP2002255846A (ja) * | 2001-02-26 | 2002-09-11 | Sunstar Inc | 経口組成物 |
| CA2341952A1 (en) | 2001-03-23 | 2002-09-23 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory pulmonary diseases |
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| US8039459B2 (en) | 2004-07-15 | 2011-10-18 | Universite Laval | Nicotinic receptor agonists for the treatment of inflammatory diseases |
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| PL364348A1 (en) | 2004-01-12 | 2005-07-25 | PHARMENA Sp.z o.o. | Application of quaternary pyridine salts as vessel protection agent |
| CN101076331A (zh) | 2004-11-05 | 2007-11-21 | 艾尼纳制药公司 | 包含烟酸受体部分促效剂的用于治疗发红和脂质相关病症的组合物 |
| AU2006329564A1 (en) | 2005-07-11 | 2007-07-05 | Pharmena North America Inc. | Formulations for treatment of lipoprotein abnormalities comprising a statin a statin and a methylnicotinamide derivative |
| JP2010506900A (ja) * | 2006-10-18 | 2010-03-04 | デルメナ | リポ蛋白質異常症並びに皮膚疾病および皮膚障害の処置のためのｎ−メチルニコチンアミドを含有する食品抽出物 |
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- 2005-01-07 PL PL05726215T patent/PL1713480T3/pl unknown
- 2005-01-07 RU RU2006129299/15A patent/RU2366420C2/ru active
- 2005-01-07 US US10/585,892 patent/US7935717B2/en active Active
- 2005-01-07 DK DK05726215.6T patent/DK1713480T3/da active
- 2005-01-07 JP JP2006548308A patent/JP5052138B2/ja not_active Expired - Lifetime
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- 2005-01-07 CN CN2005800017124A patent/CN1905875B/zh not_active Expired - Lifetime
- 2005-01-07 AT AT05726215T patent/ATE524179T1/de active
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