ATE518863T1 - 2,2-bis(hydroxymethyl)cyclopropyliden methylpurine und pyrimidine als antivirale mittel - Google Patents

2,2-bis(hydroxymethyl)cyclopropyliden methylpurine und pyrimidine als antivirale mittel

Info

Publication number
ATE518863T1
ATE518863T1 AT03748894T AT03748894T ATE518863T1 AT E518863 T1 ATE518863 T1 AT E518863T1 AT 03748894 T AT03748894 T AT 03748894T AT 03748894 T AT03748894 T AT 03748894T AT E518863 T1 ATE518863 T1 AT E518863T1
Authority
AT
Austria
Prior art keywords
amino
purine
cyclopropyliden
methylpurines
pyrimidines
Prior art date
Application number
AT03748894T
Other languages
English (en)
Inventor
Jiri Zemlicka
John C Drach
Shaoman Zhou
Original Assignee
Univ Wayne State
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wayne State, Univ Michigan filed Critical Univ Wayne State
Application granted granted Critical
Publication of ATE518863T1 publication Critical patent/ATE518863T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03748894T 2002-03-15 2003-03-14 2,2-bis(hydroxymethyl)cyclopropyliden methylpurine und pyrimidine als antivirale mittel ATE518863T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36451802P 2002-03-15 2002-03-15
PCT/US2003/007916 WO2003104440A2 (en) 2002-03-15 2003-03-14 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents

Publications (1)

Publication Number Publication Date
ATE518863T1 true ATE518863T1 (de) 2011-08-15

Family

ID=29736035

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03748894T ATE518863T1 (de) 2002-03-15 2003-03-14 2,2-bis(hydroxymethyl)cyclopropyliden methylpurine und pyrimidine als antivirale mittel

Country Status (9)

Country Link
US (3) US7393855B2 (de)
EP (1) EP1490368B1 (de)
AT (1) ATE518863T1 (de)
AU (1) AU2003267947B2 (de)
CA (1) CA2479039C (de)
DK (1) DK1490368T3 (de)
ES (1) ES2370114T3 (de)
PT (1) PT1490368E (de)
WO (1) WO2003104440A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5420135B2 (ja) 2002-03-15 2014-02-19 ウエイン・ステイト・ユニバーシテイ 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン
CA2602097A1 (en) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited Process for producing carbapenem derivatives having 1-alkylpyrrolidine structure
WO2011022712A1 (en) * 2009-08-21 2011-02-24 Epiphany Biosciences, Inc. Method of treating infectious mononucleosis with acylic nucleoside derivatives
JP7337855B2 (ja) 2018-03-09 2023-09-04 メディヴィル・アクチエボラーグ （２，２－ビスヒドロキシメチル）メチレンシクロプロパンヌクレオチドを用いたがんの治療
AU2020236933B2 (en) * 2019-03-08 2023-05-11 Microbiotix, Inc. Inhibition of adenovirus with filociclovir

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
JP5420135B2 (ja) 2002-03-15 2014-02-19 ウエイン・ステイト・ユニバーシテイ 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン

Also Published As

Publication number Publication date
CA2479039C (en) 2011-06-28
US20110275652A1 (en) 2011-11-10
EP1490368A4 (de) 2006-07-19
WO2003104440A3 (en) 2004-04-01
WO2003104440A2 (en) 2003-12-18
EP1490368B1 (de) 2011-08-03
US20090118308A1 (en) 2009-05-07
PT1490368E (pt) 2011-10-24
CA2479039A1 (en) 2003-12-18
US7393855B2 (en) 2008-07-01
AU2003267947B2 (en) 2008-11-13
EP1490368A2 (de) 2004-12-29
US8232275B2 (en) 2012-07-31
US20050113393A1 (en) 2005-05-26
AU2003267947A1 (en) 2003-12-22
ES2370114T3 (es) 2011-12-12
DK1490368T3 (da) 2011-10-03

Similar Documents

Publication Publication Date Title
PT1165560E (pt) 2-hidroximetilciclopropilidenometil-purinas e -pirimidinas como agentes antivirais
ATE254132T1 (de) Antivirale pyrimidin nucleoside derivate
Brown The Pyrimidines, Volume 52
MXPA04003795A (es) Compuestos de pirimidina y composiciones farmaceuticas que contienen los compuestos.
DE60206756D1 (de) Purin derivate als a2b adenosin rezeptor antagonisten
ATE242245T1 (de) Pyrrolo(2,3-d)pyrimidine und ihre verwendung als tyrosinkinase-inhibitoren
ATE386727T1 (de) Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf)
ATE389656T1 (de) Pyrazolo(1,5-a)pyrimidin-verbindungen als antivirale agentien
ATE166655T1 (de) 1,5-anhydrohexitolnukleosidanaloge und pharmazeutische verwendung davon
PE20010758A1 (es) DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA SUSTITUIDOS POR HETEROALQUILO COMO INHIBIDORES DE QUINASAS p38
ATE224396T1 (de) N-substituierte-dihydroxyborylalkyl derivate von purin, indol und pyrimidin, geeignet als inhibitore von entzündliche cytokine
Hess et al. 7-Deazaadenines Bearing Polar Substituents: Structure− Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists
CY1106012T1 (el) Thieno[2,3-d]pyrimidines με συνδυασμενη αγωνιστικη δραστηριοτητα της ωχρινοτροπου (lh) και της ωοθυλακιοτροπου (fsh) ορμονης
DE602004018637D1 (de) A2a-adenosinrezeptorantagonisten
ATE518863T1 (de) 2,2-bis(hydroxymethyl)cyclopropyliden methylpurine und pyrimidine als antivirale mittel
Federico et al. 5, 7-Disubstituted-[1, 2, 4] triazolo [1, 5-a][1, 3, 5] triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors
WO2003068776A1 (fr) Derives de (1, 2, 4) triazolo (1,5-c) pyrimidine
ATE403656T1 (de) Xanthinderivate als a2b- adenosinrezeptorantagonisten
Ferrarini et al. A Novel Class of Highly Potent and Selective A1 Adenosine Antagonists: Structure− Affinity Profile of a Series of 1, 8-Naphthyridine Derivatives
ES2105684T3 (es) Derivados insaturados de fosfonato de purinas y pirimidinas.
DE59704973D1 (de) Nucleosid-derivate mit photolabilen schutzgruppen
De Clercq Nucleoside Analogues Exerting Antiviral Activity Through a Non‐nucleoside Mechanism
DK1305296T3 (da) 5-substituerede pyrimidinderivater af konformationsfastlagte nucleosidanaloge
WO2004062609A3 (en) Pyrimidine derivatives as il-8 receptor antagonists
BR0307369A (pt) Uso de 4-(2-fluoro-fenil)-6-metil-2-(1-piperazinil)-tieno (2,3-d)-pirimidina para o tratamento de incontinência urinária

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1490368

Country of ref document: EP