ATE51623T1 - Aktive verbindungen. - Google Patents

Aktive verbindungen.

Info

Publication number
ATE51623T1
ATE51623T1 AT85107634T AT85107634T ATE51623T1 AT E51623 T1 ATE51623 T1 AT E51623T1 AT 85107634 T AT85107634 T AT 85107634T AT 85107634 T AT85107634 T AT 85107634T AT E51623 T1 ATE51623 T1 AT E51623T1
Authority
AT
Austria
Prior art keywords
sub
alkyl
hydrogen
phenyl
cycloalkyl
Prior art date
Application number
AT85107634T
Other languages
English (en)
Inventor
Guy Nadler
Polles Jean-Bernard Le
Marie-Noelle Legave
Original Assignee
Beecham Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Lab Sa filed Critical Beecham Lab Sa
Application granted granted Critical
Publication of ATE51623T1 publication Critical patent/ATE51623T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT85107634T 1984-06-30 1985-06-20 Aktive verbindungen. ATE51623T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848416724A GB8416724D0 (en) 1984-06-30 1984-06-30 Active compounds
EP85107634A EP0167901B1 (de) 1984-06-30 1985-06-20 Aktive Verbindungen

Publications (1)

Publication Number Publication Date
ATE51623T1 true ATE51623T1 (de) 1990-04-15

Family

ID=10563258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85107634T ATE51623T1 (de) 1984-06-30 1985-06-20 Aktive verbindungen.

Country Status (14)

Country Link
US (1) US4853391A (de)
EP (1) EP0167901B1 (de)
JP (1) JPH0699430B2 (de)
AT (1) ATE51623T1 (de)
AU (1) AU583520B2 (de)
CA (1) CA1296730C (de)
DE (1) DE3576956D1 (de)
ES (4) ES8701157A1 (de)
GB (1) GB8416724D0 (de)
GR (1) GR851602B (de)
IE (1) IE58102B1 (de)
MX (1) MX164198B (de)
NZ (1) NZ212588A (de)
ZA (1) ZA854902B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213696B1 (de) * 1985-06-28 1991-01-23 Beecham Wuelfing GmbH & Co KG Tetrahydropyrido-[1,2-a]-indolderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4624954A (en) * 1985-12-20 1986-11-25 American Home Products Corporation 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments
EP0252643A1 (de) * 1986-07-01 1988-01-13 BEECHAM - WUELFING GmbH & Co. KG Pyrido[1,2-a]indolderivate, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen, die sie enthalten
CA1329597C (en) * 1986-12-22 1994-05-17 Dagmar Hoeltje Derivatives of tetrahydropyrido[1,2-a]indole
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
ATE319683T1 (de) * 1998-12-11 2006-03-15 Univ Virginia Commonwealth Selektive 5-ht 6-rezeptor-liganden
EP1693366A1 (de) * 1998-12-11 2006-08-23 Virginia Commonwealth University Selektive 5-HT6-Rezeptorliganden
EP1132389A1 (de) 2000-03-06 2001-09-12 Vernalis Research Limited Neue Azaindolyl-Derivate für die Behandlung von Fettleibigheit
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US7608626B2 (en) 2004-11-01 2009-10-27 Wyeth Substituted indolizines and derivatives as CNS agents
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1550496A (en) * 1976-12-31 1979-08-15 Logeais Labor Jacques 1,2,3,3a4,5-hexahydro-canthine derivatives a process for their preparation and their therapeutic applications
US4328343A (en) * 1978-03-13 1982-05-04 The United States Of America As Represented By The Department Of Health And Human Services Cobalt-catalyzed one-step synthesis of annulated pyridines
EP0036269A1 (de) * 1980-03-15 1981-09-23 Beecham Group Plc Substituierte Benzamide
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
EP0213696B1 (de) * 1985-06-28 1991-01-23 Beecham Wuelfing GmbH & Co KG Tetrahydropyrido-[1,2-a]-indolderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US4624954A (en) * 1985-12-20 1986-11-25 American Home Products Corporation 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments

Also Published As

Publication number Publication date
IE58102B1 (en) 1993-06-30
EP0167901A2 (de) 1986-01-15
ES8701157A1 (es) 1986-11-16
ES552654A0 (es) 1987-03-16
AU4424385A (en) 1986-01-02
ES8704166A1 (es) 1987-03-16
NZ212588A (en) 1989-01-06
EP0167901A3 (en) 1987-05-13
DE3576956D1 (de) 1990-05-10
JPS6130587A (ja) 1986-02-12
ES8704165A1 (es) 1987-03-16
IE851633L (en) 1985-12-30
ZA854902B (en) 1986-05-28
CA1296730C (en) 1992-03-03
GR851602B (de) 1985-11-25
ES544729A0 (es) 1986-11-16
AU583520B2 (en) 1989-05-04
ES552655A0 (es) 1987-03-16
ES552653A0 (es) 1987-03-16
JPH0699430B2 (ja) 1994-12-07
EP0167901B1 (de) 1990-04-04
MX164198B (es) 1992-07-23
ES8704164A1 (es) 1987-03-16
US4853391A (en) 1989-08-01
GB8416724D0 (en) 1984-08-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee