ES8704164A1 - Un procedimiento para la preparacion de derivados de secocantina - Google Patents
Un procedimiento para la preparacion de derivados de secocantinaInfo
- Publication number
- ES8704164A1 ES8704164A1 ES552653A ES552653A ES8704164A1 ES 8704164 A1 ES8704164 A1 ES 8704164A1 ES 552653 A ES552653 A ES 552653A ES 552653 A ES552653 A ES 552653A ES 8704164 A1 ES8704164 A1 ES 8704164A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- phenyl
- cycloalkyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE SECOCANTINA. CONSISTENTE EN LA OBTENCION DE COMPUESTOS DE FORMULA (I), DONDE R1 ES HIDROGENO, ALQUILO, ALCOXI O HALOGENO; R2 Y R3 SON HIDROGENO O, CONJUNTAMENTE, UN ENLACE; R4 Y R5 SON HIDROGENO O UN GRUPO OXO; R7 ES HIDROGENO O ALQUILO; Y R6 SE ESCOGE ENTRE DIFERENTES RADICALES. MEDIANTE LA ALQUILACION DE UN COMPUESTO DE FORMULA (II), OPCIONALMENTE SEGUIDA, O SIMULTANEAMENTE, DE UNA REDUCCION DEL GRUPO OXO R4/R5, DE LA REDUCCION DEL DOBLE ENLACE R2/R3 Y DE LA FORMACION DE UNA SAL DE INTERES FARMACOLOGICO. DE APLICACION POR SU ACTIVIDAD ANTIHIPOXICA Y PARA SUPLIR LA CARENCIA DE OXIGENO CEREBRAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848416724A GB8416724D0 (en) | 1984-06-30 | 1984-06-30 | Active compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES552653A0 ES552653A0 (es) | 1987-03-16 |
ES8704164A1 true ES8704164A1 (es) | 1987-03-16 |
Family
ID=10563258
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544729A Expired ES8701157A1 (es) | 1984-06-30 | 1985-06-28 | Un procedimiento para la preparacion de derivados de secocantina. |
ES552655A Expired ES8704166A1 (es) | 1984-06-30 | 1986-03-04 | Un procedimiento para la preparacion de derivados de secocantina |
ES552654A Expired ES8704165A1 (es) | 1984-06-30 | 1986-03-04 | Un procedimiento para la preparacion de derivados de secocantina |
ES552653A Expired ES8704164A1 (es) | 1984-06-30 | 1986-03-04 | Un procedimiento para la preparacion de derivados de secocantina |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544729A Expired ES8701157A1 (es) | 1984-06-30 | 1985-06-28 | Un procedimiento para la preparacion de derivados de secocantina. |
ES552655A Expired ES8704166A1 (es) | 1984-06-30 | 1986-03-04 | Un procedimiento para la preparacion de derivados de secocantina |
ES552654A Expired ES8704165A1 (es) | 1984-06-30 | 1986-03-04 | Un procedimiento para la preparacion de derivados de secocantina |
Country Status (14)
Country | Link |
---|---|
US (1) | US4853391A (es) |
EP (1) | EP0167901B1 (es) |
JP (1) | JPH0699430B2 (es) |
AT (1) | ATE51623T1 (es) |
AU (1) | AU583520B2 (es) |
CA (1) | CA1296730C (es) |
DE (1) | DE3576956D1 (es) |
ES (4) | ES8701157A1 (es) |
GB (1) | GB8416724D0 (es) |
GR (1) | GR851602B (es) |
IE (1) | IE58102B1 (es) |
MX (1) | MX164198B (es) |
NZ (1) | NZ212588A (es) |
ZA (1) | ZA854902B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0213696B1 (en) | 1985-06-28 | 1991-01-23 | Beecham Wuelfing GmbH & Co KG | Tetrahydropyrido [1,2-a] indole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
US4624954A (en) * | 1985-12-20 | 1986-11-25 | American Home Products Corporation | 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments |
EP0252643A1 (en) * | 1986-07-01 | 1988-01-13 | BEECHAM - WUELFING GmbH & Co. KG | Pyrido[1,2-a]indole derivatives, process for their preparation and pharmaceutical compounds containing them |
CA1329597C (en) * | 1986-12-22 | 1994-05-17 | Dagmar Hoeltje | Derivatives of tetrahydropyrido[1,2-a]indole |
US5290785A (en) * | 1988-09-27 | 1994-03-01 | Fujisawa Pharmaceutical Co., Ltd. | Therapeutic agent for ischemic diseases |
GB9819035D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
WO2000034242A1 (en) * | 1998-12-11 | 2000-06-15 | Virginia Commonwealth University | Selective 5-ht6 receptor ligands |
EP1693366A1 (en) * | 1998-12-11 | 2006-08-23 | Virginia Commonwealth University | Selective 5-HT 6 receptor ligands |
EP1132389A1 (en) * | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
MX2007005199A (es) | 2004-11-01 | 2007-05-11 | Wyeth Corp | Indolizinas sustituidas y derivados como agentes del sistema nervioso central. |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
WO2010095940A2 (en) | 2009-02-20 | 2010-08-26 | To-Bbb Holding B.V. | Glutathione-based drug delivery system |
NZ596876A (en) | 2009-05-06 | 2014-01-31 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1550496A (en) * | 1976-12-31 | 1979-08-15 | Logeais Labor Jacques | 1,2,3,3a4,5-hexahydro-canthine derivatives a process for their preparation and their therapeutic applications |
US4328343A (en) * | 1978-03-13 | 1982-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Cobalt-catalyzed one-step synthesis of annulated pyridines |
EP0036269A1 (en) * | 1980-03-15 | 1981-09-23 | Beecham Group Plc | Substituted benzamides |
US4595688A (en) * | 1983-06-23 | 1986-06-17 | Mcneilab, Inc. | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof |
EP0213696B1 (en) * | 1985-06-28 | 1991-01-23 | Beecham Wuelfing GmbH & Co KG | Tetrahydropyrido [1,2-a] indole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them |
US4624954A (en) * | 1985-12-20 | 1986-11-25 | American Home Products Corporation | 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments |
-
1984
- 1984-06-30 GB GB848416724A patent/GB8416724D0/en active Pending
-
1985
- 1985-06-20 AT AT85107634T patent/ATE51623T1/de not_active IP Right Cessation
- 1985-06-20 DE DE8585107634T patent/DE3576956D1/de not_active Expired - Fee Related
- 1985-06-20 EP EP85107634A patent/EP0167901B1/en not_active Expired - Lifetime
- 1985-06-27 AU AU44243/85A patent/AU583520B2/en not_active Ceased
- 1985-06-28 IE IE163385A patent/IE58102B1/en not_active IP Right Cessation
- 1985-06-28 ES ES544729A patent/ES8701157A1/es not_active Expired
- 1985-06-28 MX MX8192A patent/MX164198B/es unknown
- 1985-06-28 NZ NZ212588A patent/NZ212588A/xx unknown
- 1985-06-28 CA CA000485991A patent/CA1296730C/en not_active Expired - Fee Related
- 1985-06-28 ZA ZA854902A patent/ZA854902B/xx unknown
- 1985-06-28 US US06/750,038 patent/US4853391A/en not_active Expired - Lifetime
- 1985-06-28 GR GR851602A patent/GR851602B/el unknown
- 1985-07-01 JP JP60144423A patent/JPH0699430B2/ja not_active Expired - Lifetime
-
1986
- 1986-03-04 ES ES552655A patent/ES8704166A1/es not_active Expired
- 1986-03-04 ES ES552654A patent/ES8704165A1/es not_active Expired
- 1986-03-04 ES ES552653A patent/ES8704164A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0167901A3 (en) | 1987-05-13 |
ES8704166A1 (es) | 1987-03-16 |
ES552655A0 (es) | 1987-03-16 |
EP0167901A2 (en) | 1986-01-15 |
NZ212588A (en) | 1989-01-06 |
CA1296730C (en) | 1992-03-03 |
ES552654A0 (es) | 1987-03-16 |
JPS6130587A (ja) | 1986-02-12 |
ES544729A0 (es) | 1986-11-16 |
ES552653A0 (es) | 1987-03-16 |
IE851633L (en) | 1985-12-30 |
US4853391A (en) | 1989-08-01 |
GB8416724D0 (en) | 1984-08-01 |
ES8701157A1 (es) | 1986-11-16 |
MX164198B (es) | 1992-07-23 |
DE3576956D1 (de) | 1990-05-10 |
AU4424385A (en) | 1986-01-02 |
ES8704165A1 (es) | 1987-03-16 |
GR851602B (es) | 1985-11-25 |
EP0167901B1 (en) | 1990-04-04 |
AU583520B2 (en) | 1989-05-04 |
IE58102B1 (en) | 1993-06-30 |
ATE51623T1 (de) | 1990-04-15 |
JPH0699430B2 (ja) | 1994-12-07 |
ZA854902B (en) | 1986-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070131 |