ATE510843T1 - Verfahren zur synthese von peptiden ohne lösungsmittel - Google Patents

Verfahren zur synthese von peptiden ohne lösungsmittel

Info

Publication number
ATE510843T1
ATE510843T1 AT08718144T AT08718144T ATE510843T1 AT E510843 T1 ATE510843 T1 AT E510843T1 AT 08718144 T AT08718144 T AT 08718144T AT 08718144 T AT08718144 T AT 08718144T AT E510843 T1 ATE510843 T1 AT E510843T1
Authority
AT
Austria
Prior art keywords
group
alkyl
synthesing
peptides
solvents
Prior art date
Application number
AT08718144T
Other languages
English (en)
Inventor
Jean Martinez
Frederic Lamaty
Valerie Declerck
Original Assignee
Centre Nat Rech Scient
Univ Montpellier I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Montpellier I filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE510843T1 publication Critical patent/ATE510843T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT08718144T 2007-03-21 2008-03-21 Verfahren zur synthese von peptiden ohne lösungsmittel ATE510843T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0753970A FR2913978B1 (fr) 2007-03-21 2007-03-21 Procede de synthese de peptides sans solvant
PCT/EP2008/053444 WO2008125418A2 (fr) 2007-03-21 2008-03-21 Procede de synthese de peptides sans solvant

Publications (1)

Publication Number Publication Date
ATE510843T1 true ATE510843T1 (de) 2011-06-15

Family

ID=38293308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08718144T ATE510843T1 (de) 2007-03-21 2008-03-21 Verfahren zur synthese von peptiden ohne lösungsmittel

Country Status (8)

Country Link
US (1) US7960578B2 (de)
EP (1) EP2139910B1 (de)
JP (1) JP5362593B2 (de)
AT (1) ATE510843T1 (de)
CA (1) CA2681321A1 (de)
ES (1) ES2366001T3 (de)
FR (1) FR2913978B1 (de)
WO (1) WO2008125418A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016026641B1 (pt) * 2014-05-28 2023-03-14 Astrazeneca Ab Processos para a preparação de azd5363 e novo intemediário utilizado nos mesmos
EP3527580B1 (de) * 2018-02-16 2021-04-07 Centre National de la Recherche Scientifique CNRS Kontinuierliche, lösungsmittelfreie und nicht-enzymatische peptidsynthese durch reaktive extrusion
JP7356707B2 (ja) * 2018-11-15 2023-10-05 国立大学法人神戸大学 アミノ酸－ｎ－カルボン酸無水物の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU673731B2 (en) * 1993-06-03 1996-11-21 Banyu Pharmaceutical Co., Ltd. Novel endothelin antagonistic peptide
FR2858976B1 (fr) * 2003-08-22 2006-02-10 Isochem Sa Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane

Also Published As

Publication number Publication date
US20100016631A1 (en) 2010-01-21
WO2008125418A3 (fr) 2008-12-18
WO2008125418A2 (fr) 2008-10-23
FR2913978B1 (fr) 2009-07-03
FR2913978A1 (fr) 2008-09-26
ES2366001T3 (es) 2011-10-14
JP5362593B2 (ja) 2013-12-11
US7960578B2 (en) 2011-06-14
EP2139910A2 (de) 2010-01-06
CA2681321A1 (fr) 2008-10-23
EP2139910B1 (de) 2011-05-25
JP2010522144A (ja) 2010-07-01

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Legal Events

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